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H J Gütz

Publications and source records attributed to H J Gütz.

At least 19 recordsLinked to original sources
PubMed1989

DNA distribution pattern in chronic gastritis. I. DNA ploidy and cell cycle distribution.

DNA distribution patterns were flow cytometrically recorded in gastric biopsy specimens from patients with chronic gastritis (CG) and chronic atrophic gastritis (CAG). DNA aneuploidy was found in 3 of 58 patients with CG and in 7 of 82 patients with CAG. Cell cycle analysis disclosed significantly higher percentages of cells in S-phase and G2M-phase, respectively, in CAG than in CG. With regard to the proliferative activity the total CAG group could be partially differentiated by the degree of severity. CAG with total atrophy showed significantly higher percentages of cells in S-phase than CAG with mild and moderate atrophy. CAG without dysplasia showed lower percentages of cells in S-phase and G2M-phase than CAG with severe dysplasia (p greater than 0.05). The occurrence of intestinal metaplasia was correlated to a significantly higher percentage of cells in G2M-phase.

Adult↗
PubMed1987

[Atrophic corpus gastritis and autoimmune gastritis].

The authors tried to clarify relations between autoimmune gastritis and isolated atrophic corpus gastritis by bioptic corporal and antral examinations from 150 probands as well as examinations of gastrin in serum and parietal cell antibody tests. Only 30% of all patients examined with isolated atrophic gastritis of the corpus part revealed criteria of an autoimmune gastritis. Therefore investigations of antibodies against parietal cells are necessary to mark off both clinical pictures. This differentiation seems to be necessary regarding the high risk of gastric cancer following an autoimmune gastritis.

Autoantibodies↗
PubMed1986

[Signet-ring-cell lymphoma. Light and electron microscopic study of gastric involvement].

The authors report on a malignant Non-Hodgkin lymphoma of the stomach of a 73-year-old male. Histologically, it was revealed to be a follicularly growing, obviously secondary centroblastic lymphoma. Crystalline cytoplasmic inclusions in numerous centrocytes have led to displacement of the nucleus to the cell margin and thus to the picture of a signet-ring-cell lymphoma. Electronmicroscopically, there were found big crystalline electron-dense deposits in the rough endoplasmic reticulum. The finding was compared with literature data, and the histological differential diagnosis is discussed.

Aged↗
PubMed1984

A comparative study of early gastric cancer.

Authors provided a comparative study of early gastric cancers (EGC) which were found in the Cancer Research Centre of the Academy of Medical Sciences of USSR (Group A) and in the Central Institute of Cancer Research of the Academy of Sciences of GDR (Group B). The most frequent EGC-type in group B was type II, while types I and III were more frequent in group A. The rate of lymph node metastases in group A was 4,54% versus 16,2% in group B. Multicentric cancers were more often found in group A. These findings strengthen the opinion that early gastric cancer is not a uniform biological entity. Accuracy of x-ray and gastroscopic diagnoses was higher in group A. This fact surely contributes to the better prognosis of early gastric cancer in this group.

Female↗
PubMed1983

Difference in chromatin sensitivity to heparin of chronic atrophic gastritis, of carcinoma-free and carcinoma-bearing stomach in comparison with normal gastric mucosa and gastric carcinoma as revealed by flow cytometry.

DNA distribution patterns from gastric mucosal cells corresponding to four groups defined by histological examination were measured by flow cytometry before and after treatment with heparin, a polyanion. Group I comprised normal gastric mucosal cells; group II, chronic atrophic gastric mucosal cells originating from a carcinoma free stomach; group III, chronic atrophic gastric mucosal cells originating from a carcinoma bearing stomach; and group IV, malignant gastric mucosal cells. The heparin concentrations used were 1.25, 1.5, and 5 U/ml cell suspension. Heparin caused increases in fluorescence intensity and in coefficients of variation, which are interpreted as a reflection of alterations in chromatin structure. For the four groups investigated, the heparin-initiated changes were dependent, in varying degree, on concentration and time. Group I showed a much more extensive sensitivity to heparin than group IV. Group II and III reacted similarly to group I or group IV, depending on the source, i.e., either a carcinoma-free stomach or a carcinoma-bearing stomach. Further extension of this method might yield information concerning the real premalignant potential of a specific case of chronic atrophic gastritis.

Chromatin↗
PubMed1983

[Parietal cell antibodies and stomach cancer].

Sera of 101 patients with histologically confirmed gastric cancers were investigated for parietal cell antibodies, which are the serological markers of chronic atrophic gastritis type A. These autoantibodies were more often found in patients with early than with advanced gastric cancers. They were more frequent in intestinal than in diffuse gastric cancers. It is discussed that in advanced cancers the frequency of parietal cell antibody is diminishing because of loss of antigene or binding of antibodies in immune complexes. Early gastric cancers therefore seem to be more suitable than advanced cancers to study the relation between gastric cancer and gastritis type.

Antigen-Antibody Complex↗
PubMed1982

Flow cytometry, cytomorphology, histology and autoradiography in human gastric hyperplastic polyps and the surrounding mucosa.

43 cases of gastric hyperplastic polyps, 33 tissues adjoining the polyps and 7 tissue samples of the corpus mucosa were investigated by flow cytometry, cytomorphology, autoradiography and histology, respectively. All cases revealed diploid DNA distribution patterns. The results attributed an increased proliferative tendency to special cases of hyperplastic polyps and the surrounding mucosa.

Autoradiography↗
PubMed1982

[Clinical aspects of cancer of the resected stomach].

From 1962 to 1980 54 patients suffering from gastric carcinoma following partial gastrectomy were admitted to the Central Institute for Cancer Research of the Academy of Sciences of the GDR. No surgical therapy was possible in 13 additional cases due to distant metastases. In all patients operated upon a considerable expansion of the tumour could be observed. For an early detection of the carcinoma in the resected stomach a regular prophylactic examination by endoscopy should be practiced.

Aged↗