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H J Gassel

Publications and source records attributed to H J Gassel.

At least 55 records · Page 3Linked to original sources
PubMed1997

[Gardner syndrome and thyroid gland carcinoma].

We report on the case of a 23-year-old female with a 5-year history of Gardner's syndrome, who developed a bifocal, papillary carcinoma of the thyroid. The combination of familial adenomatous polyposis with a thyroid cancer is a rare but well-documented association. Typically, histology reveals a multifocal, papillary tumour with a predominantly good prognosis. This type of carcinoma is almost exclusively confined to females in their second decade of life, and it may, in fact, precede the onset of the polyposis manifestation. Patients suffering from familial adenomatous polyposis should therefore undergo regular clinical examination of the thyroid gland. If a neoplastic lesion is suspected, immediate scintigraphic evaluation should be carried out, with fine-needle aspiration of equivocal foci if necessary, and/or intraoperative frozen section. When a carcinoma is found, total thyroidectomy with dissection of the central lymph compartments should be considered the treatment of choice because of the high likelihood of the tumour being multicentric.

Adult↗
PubMed1997

[Effect of modern instrumental diagnosis on surgical indications for resection of colorectal liver metastases].

In order to select those patients with colorectal liver metastases who may have benefit from an operation, preoperative detection and localization of tumors in the liver is necessary. In this study, the specificity and sensitivity of a CT arterial portography and magnetic resonance imaging with contrast media was compared with the results of operative findings and intraoperative ultrasonography. The combination of both preoperative methods led to an accuracy rate of more than 90%, and all patients who underwent laparotomy were resected or treated with an arterial infusion port system. Negative laparotomies were excluded completely.

Colorectal Neoplasms↗
PubMed1995

[Combined liver-islet transplantation after epigastric exenteration in carcinoma of Vater's ampulla].

A 44 year old female underwent an upper abdominal exenteration because of an adenocarcinoma of the pancreas with liver metastases (T1 N1 M1). Reconstruction was performed by orthotopic liver transplantation and intraportal islet transplantation. Due to initial non function of the first liver graft, a second liver transplantation was performed. Thereafter, the patient received 375,000 islet equivalents of the primary liver donor in addition to 295,400 islet equivalents of another donor. Six months postoperatively, the patient is off insulin except irregular injections of 4-6 units of insulin to protect her from hyperglycemia after lunch. CT scans of the liver do not show any signs of tumor recurrence. Upper abdominal exenteration with consecutive islet transplantation offers a good method of reconstruction after radical surgery in the upper abdomen. The oncological aspects of the procedure have to be further investigated.

Adenocarcinoma↗
PubMed1993

Effect of orthotopic transplantation and chemical denervation of the liver on hepatic hemodynamics in the rat.

The involvement of the sympathetic nervous system in the control of basal hepatic hemodynamics was investigated. Hepatic denervation was achieved by orthotopic transplantation or chemical denervation of the organ. In male Lewis rats, transplantation with rearterialization of the graft was performed. Chemical denervation was achieved by intraportal injection of 6-hydroxydopamine (75 mg/kg). Normal liver physiology was confirmed by histology and liver function tests. Four weeks post-transplantation and 7 days post-denervation, histological examination revealed no differences between transplanted, denervated and untreated or sham-operated control animals. Liver function measured by standard tests (e.g., plasma SGOT, bilirubin) was normal in all groups. The rate constants for aminopyrine breakdown in transplanted (0.015 +/- 0.005 min-1), denervated (0.015 +/- 0.0012 min-1) and control rats (0.015 +/- 0.001 min-1) were not significantly different. No significant difference in the rate of galactose breakdown was found. Total liver blood flow (measured by the 133Xe clearance technique in the anesthetized animal) was unaffected by transplantation (rate constant, 0.245 +/- 0.062 min-1; control 0.279 +/- 0.011 min-1). The interlobular distribution of portal blood flow was tested by intraportal injection of 51Cr-labelled microspheres. A linear relationship between flow to lobe and lobe size was confirmed in control (r = 0.95), denervated, (r = 0.99) and transplanted rats (r = 0.97) and the 'relative' flow to each lobe was not significantly different in the 3 groups. No significant differences in the 'core' to 'periphery' distribution of portal blood flow were found in the 3 groups. A small but significant portal systemic shunt was found in transplanted but not denervated or control animals.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1993

Selective sympathectomy of the liver: a comparison of orthotopic liver transplantation and intraportal 6-hydroxydopamine injection.

1. Tissue noradrenaline (NA) levels correlate well with the extent of sympathetic innervation of that tissue. 2. In this study the distribution of NA throughout the different lobes of the rat liver was studied. The extent of sympathectomy by means of either orthotopic liver transplantation (OLT) (n = 7) or chemical denervation by intraportal administration of 6-hydroxydopamine (6-OH-DA) (n = 8) was examined. 3. In the normally innervated rat liver, NA was homogeneously distributed throughout the organ. Tissue NA was decreased both by OLT (> 99%) and 6-OH-DA (93%) (both P < 0.001 versus control). 4. Samples of the renal cortex and left ventricle were taken as reference tissues. OLT did not result in any change in reference tissue NA, however, 6-OH-DA decreased renal cortex NA by 93% and ventricular NA by 76%, respectively (both P < 0.01 versus OLT). 5. We conclude that OLT causes selective and complete hepatic sympathectomy but that 6-OH-DA causes incomplete denervation of the liver and significant denervation of other organs.

Animals↗
PubMed1992

The role of T suppressor cells in the maintenance of spontaneously accepted orthotopic rat liver allografts.

Orthotopic liver allografts from BN donors to LEW recipients are spontaneously accepted, and the recipients develop donor-specific immunological unresponsiveness. This unresponsiveness may be mediated by suppressor T cells. Immunomagnetically purified splenic T cells from LEW rats bearing BN liver grafts were shown to adoptively transfer suppression of skin, heart, and kidney graft rejection in a donor-specific manner, prolonging the survival of BN but not third-party DA grafts. However, the suppressor T cells were sessile, being resident in the spleen but not present in thoracic duct lymph. The presence of a nonrecirculating suppressor T cell in rats spontaneously accepting liver transplants is strongly suggestive of an important function in the maintenance of donor-specific unresponsiveness, although the contribution of other possible mechanisms of unresponsiveness has not been investigated.

Animals↗
PubMed1991

Malignant lymphoma of donor origin after renal transplantation: a case report.

A case of non-Hodgkin's lymphoma of polymorphous centroblastic type presenting in a renal allograft is reported. The kidney graft was explanted 10 months after transplantation because of chronic rejection. No other manifestations of lymphoma were found in the recipient. Since the human leukocyte antigen patterns of the renal allograft and the recipient differed at two loci, the donor origin of the malignancy could be clearly demonstrated by immunohistochemistry.

Adult↗