Significance of Lewis and HLA system in kidney transplantation: a multicenter study in Germany.
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Biomedical subjects
Publications and source records attributed to H J Halbfass.
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Retrospective HLA-DR-typing and the influence of HLA-DR antigen on transplantation prognosis was studied in 90 kidney donor-recipient pairs. It was clearly demonstrated that HLA-DR compatible donor kidney provides a significantly better transplant prognosis than if there is HLA-DR incompatibility. Donor kidneys with only one identical HLA-DR antigen gave a six-month survival rate of 80%. Only HLA-AB identical cadaver kidneys ("full house identity") give similar survival times. Because of relatively lower polymorphism of the HLA-DR alloantigen system, HLA-DR identical donor organs are discovered more frequently than when HLA-AB antigens are taken into consideration. HLA-DR identical donor kidneys (identical for both HLA-DR antigens) have an even better transplant prognosis than "full house identical" kidneys, since the survival rate in the former is 87% after six months.
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The mesocaval shunt has special advantages. It can be applied also in patient with worse condition (Child B and C). The technically simple performance according to the original method of Drapanas is recommended provided that anatomical variants at the surgical trunk of the vena mesenterica superior are known. The anatomical situation should be investigated preoperatively by direct (umbilical vein catheter) or indirect mesentericography. The access via umbilical vein offers in addition the possibility of coronary vein embolisation in emergency patients.
From measurement of local tissue PO2 in human kidney grafts after restoration of renal circulation, a correlation between initial microcirculation and kidney function can be drawn. PO2-histograms of kidney grafts with sufficient function are normal, whereas PO2-histograms of kidneys with delayed onset of function (congruent to 3 weeks) show distinct disturbances of microcirculation. These preliminary results suggest that measuring local tissue PO2 in transplanted kidneys may be of value for the prognosis of the graft.
By artificial embolization before extensive septic amputation arrosion bleedings that are otherwise noncontrollable can be prevented. Resorbable gelatine (Gelforam) is suitable for embolization. For safety one can leave a balloon catheter above the embolized vessel segment for several days.
In a 65-year-old patient with amputation of both legs, a life-threatening acute abdominal hemorrhage necessitates aortography. Following surgical dissection of the right femoral artery a catheter could be inserted through the thrombosed vessel into the aortic lumen. This approach made the diagnosis of a perforated aortic aneurysm by angiography possible.
Congenital choledochal cysts are classified into three types (type A = cystic dilatation, type B = diverticula, Type C = choledochocele). In addition, all cases of types A and B may have anomalies of the pancreaticobiliary duct system. In type I the pancreatic duct enters the common duct and in type II the common duct enters the pancreatic duct. These anomalies are considered etiological factors in the development of choledochal cysts and are important for prognosis and therapy. Types A and B should be mainly treated by choledochocystojejunostomy (Roux-en-Y), while in type C an endoscopic transpapillary splitting is recommended.
Similarly good survival rates were obtained in 113 patients with kidneys transplanted from deceased persons as with patients on home dialysis. The retrospective study showed that fatal complications were not predominantly caused by septic diseases running fateful courses under immunosuppression, but by risk factors which were not recognized soon enough or were incorrectly treated. In our opinion, with careful preparation and supervision of these patients, even in the still unsatisfactory state of immunosuppressive therapy, the possibility exists of carrying out renal grafting without increased risk of mortality compared with dialysis treatment.
The treatment of strictures and fistulas at the lower ureter after kidney transplantation was simple and could be achieved by reimplantation into the bladder. Proximal urinary fistulas caused early abdominal symptoms. The i.v. urogram showed a dilated renal pelvis without drainage into the ureter. The anatomical findings were in all cases strictures or total obstruction of the ureter beneath the pelvic junction and a rupture of the renal pelvis or calix. Adequate therapy consisted of ureteroureterostomy with the recipient ureter and nephrostomy splintage.
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A particular kind of renal-artery stenosis was observed in three of 60 renal transplantations performed between 1969 and 1974. It was always 1.0-1.5 cm distal to the anastomosis and, as histological examination demonstrated, was definitely due to vessel injury after removal of the transplant. To avoid it the proximal arterial stump should be cut off before transplantation. The postanastomotic region must be dissected free during the operation and an extended graft venoplasty or sleeve resection performed.
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