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Biomedical subjects

H J Harrington

Publications and source records attributed to H J Harrington.

6 recordsLinked to original sources

Abnormalities of multimodality evoked potentials in amyotrophic lateral sclerosis.

Thirty-two patients with amyotrophic lateral sclerosis were studied with somatosensory evoked potentials (SEPs), visual evoked potentials, and brain-stem auditory evoked potentials. H-reflexes were used to screen for abnormalities of peripheral nerve conduction. Nineteen patients (59%) showed an abnormality of lower extremity SEPs. In 13 patients (40%) the delay was of central origin, while in six patients (19%) peripheral conduction delay was possible. Abnormality of upper limb SEPs was seen in 11 patients (34%), all but two of whom had abnormal lower limb SEPs as well. Four patients (12%) had abnormal brain-stem auditory evoked potentials, all of whom had abnormal SEPs from upper and lower limbs. Four patients had abnormal visual evoked potentials, which in three patients were of minor degree. These results give physiologic evidence to suggest that abnormalities in amyotrophic lateral sclerosis occur outside the motor system.

Adult↗

Carotid body tumor associated with partial Horner's syndrome and facial pain ('Raeder's syndrome').

A 35-year-old woman had partial, right-sided Horner's syndrome seven years prior to admission. Facial sweating was normal. Ipsilateral headache and facial pain followed a year later. Three months before admission a left-sided carotid body tumor was resected successfully. Soon thereafter, a mass was noted below the right mandibular angle and carotid angiography showed features typical of a carotid body tumor at the carotid bifurcation. To our knowledge this is the first report of such a lesion causing Raeder's syndrome. Review of other reported cases of this usually benign syndrome shows that some may be associated with serious but treatable diseases of the internal carotid artery.

Adult↗