[Effective incorporation of lipopolysaccharides in liposomes for modulation of pyrogenicity and release of tumor necrosis factor].
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Animals↗
Biomedical subjects
H J Jacker
Publications and source records attributed to H J Jacker.
[Biological testing of biomaterials in the framework of permitted procedures. 2].
Submitted is the revised version of a proposal for a guideline for biological testing of materials (biomaterials) which remain temporarily or permanently, resp., at or in the human body or have contact with drugs or body fluids outside the human body.
Animals↗
[The toxicologic evaluation of biomaterials. 1. Results of biomaterial tests in cultures of human amnion epithelial cells and human fibroblasts].
Cell cultures are a highly sensitive toxicological model used also for the testing of biomaterials. Beside the safety tests provided in the Pharmacopoeia of GDR cultures from human amnionepithelial cells and fibroblasts are used. The paper reports the results of some methodical investigations concerning the procedure of extraction of biomaterials, the evaluation of test results and the comparison with the results of other biological tests.
Amnion↗
[Antiexudative behavior of various triterpene saponins].
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Animals↗
[Resistance of yeast cells to plastics and elastics].
For the investigation of plastics and elastics several sensitive biological methods are in use. In the Pharmacopeia of GDR, 2nd edition, a safety-test on isolated frogheart is prescribed for plastics and a safety-test on daphnia magna for elastics. Ionescu-Stoian had recommended a test using saccharomyces cerevisiae. We found a good conformity of the result given by this test with the results of the daphnia-test. On the other hand, the saccharomyces cerevisiae-test is much more sensitive than the test with isolated frogheart.
Animals↗
[Characterization of the sodium nucleinate-edema of the rat paw].
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Animals↗
[The antiexudative effect of saponin-5 from Eryngium planum L. and Sanicular europaea L].
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Animals↗
[Possibilities and limitations of the use of rat paw edemas as models of inflammation. 1. Review on edemas as models and their possible use].
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Animals↗
[The possibilities and limitations of the use of rat paw edemas as models of inflammation. 2. Possible influence of the results in examinations on paw edemas].
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Age Factors↗
[Administration of infusion solutions. 2. Solutions for parenteral feeding and plasma substitutes].
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Amino Acids↗
[Release of edemas in the rat paw due to sodium nucleinate and their modification by antiphlorgistic agents].
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Animals↗
[The use of infusion solutions. 1. Solutions for the treatment of water-electrolyte balance disorders].
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Carbohydrates↗
[Application of fel tauri in cholagogs].
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Bile Acids and Salts↗
[Standard assortment of infusion solutions in the German Democratic Republic].
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Dextrans↗
[Blood, blood components, plasma expander. 37].
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Albumins↗
On thermostability of pyrogens.
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Drug Stability↗
Remarks about some pharmacopoieal safety tests for plastics and elastomers.
A survey of the biological methods for quality control of plastics and elastomers included in pharmacopoeias is given. The value of some of these methods (test for pyrogen-like substances, test for acute systemic toxicity in mice, tests on frog hearts, on Daphnia magna and on rat sperm, mode of extraction) is discussed.
Animals↗