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Biomedical subjects

H J Leu

Publications and source records attributed to H J Leu.

At least 19 recordsLinked to original sources
PubMed1992

[Calcified and ossified phlebosclerosis].

Eight cases of dystrophic calcification and/or ossification within the walls of deep and superficial leg veins were analyzed and histologically examined. Calcification of superficial veins is a frequent clinical finding. Calcification of deep veins is occasionally observed. Ossification of the venous wall, however, has been rarely described. Calcification and ossification of the venous wall always concern the intimal layer or an organized thrombus and do not involve the media. This is in contrast to the findings in arteries where calcification and ossification of the media is frequent (Mönckeberg's mediasclerosis). The clinical consequences of calcification and ossification in the venous wall are briefly discussed.

Aged↗
PubMed1991

Morphology of chronic venous insufficiency--light and electron microscopic examinations.

The morphology of chronic venous insufficiency (cvi) as seen by light and by electron microscopy with additional immunohistological examinations is described. The course of events follows the well-known pattern of "injury and repair". The tissue injury is due to an increased capillary permeability induced by rise of the intravenous ambulatory pressure. This results in the formation of a pericapillary edema ("halo"). No evidence of a pericapillary fibrin deposition could be found, but fibrinogen might well be extravasated together with erythrocytes. The accumulation of cell debris and metabolites around the capillaries induces a secondary ("resorptive") inflammation with mobilisation of white blood cells and formation of a granulation tissue. Occlusion of small blood vessels is responsible for the development of micronecroses. These lesions have to be repaired by a new granulation tissue. Finally a fibrous scar tissue with impaired microcirculation results. Persistence of the venous stasis prevents a restitution of the tissue. Only by permanent elimination of the venous stasis, a restitution of the scar tissue may be achieved.

Capillaries↗
PubMed1991

Phlebosclerosis: disorder or disease?

Morphological examinations were performed in a total of 318 subjects (168 men and 150 women). Electron microscopic and immunohistological examinations were added in selected cases. Phlebosclerosis is a fibrotic degeneration of the venous wall that is regularly found in non-varicose veins of aged persons. Although its incidence is age-related, no correlation exists between degree and age. Marked degrees may occasionally occur already below the age of twenty. Both sexes and all the superficial leg veins (various levels of the long saphenous vein and minor venous branches) are likewise affected. The intima of the superficial leg veins is predominately involved, but media and adventitia may also be affected. Although the morphological appearance is similar to that of arteriosclerosis, localization, progression and clinical consequences are different. Phlebosclerosis of superficial leg veins is a disorder of little direct clinical consequence, but may have an indirect influence on the wall contractility. In the deep leg veins, however, a distinct phlebosclerosis of the intimal layer may be responsible for the development of thrombosis. As a secondary alteration, phlebosclerosis may complicate varicose veins (fibrous degeneration of wall areas with tortuosity, ectasia and smooth muscle atrophy). These lesions may further impair the already deficient reflux function. However, phlebosclerosis is no prerequisite but a late sequel of varicosis.

Adult↗
PubMed1990

Inflammatory abdominal aortic aneurysms: a disease entity? Histological analysis of 60 cases of inflammatory aortic aneurysms of unknown aetiology.

Sixty inflammatory aortic aneurysms of unknown aetiology were examined by serial sections. The histological findings failed to reveal significant differences in either thoracic or abdominal aneurysms with or without marked adventitial fibrosis. Their identical morphology does not favour the existence of a special disease entity of so-called inflammatory abdominal aortic aneurysms (IAAA). Absence or existence of giant cells of any type, occurrence of plasma cells, eosinophils, granulomas, fibrinoid necrosis and adventitial fibrotic thickening cannot be considered as variables which help in differentiation. IAAA are characterized by a marked predominance of male patients and a rather benign clinical course. They usually affect the age group around 60 years. They are not rare and do not seem to be restricted to certain races. Their aetiology, like that of the cases affecting the thoracic aorta (Takayasu's disease, non-specific aortitis) remains unknown, although autoimmune diseases, the retroperitoneal fibrosis of Ormond and arteriosclerosis may be related. However, on the basis of the present evidence we cannot consider them to be one of these diseases. There are no morphological findings which would justify the separation of IAAA from Takaysu's disease.

Adult↗
PubMed1990

A rare case of angiodysplasia: penetration of inguinal lymph nodes by large superficial leg veins. Report of five cases.

Five cases of veno-lymphatic angiodysplasia with penetration of one or several inguinal lymph nodes by the long saphenous vein, or one of its major branches, are reported. This malformation is usually detected during surgery for varicose veins with ligation of the long saphenous vein in the fossa ovalis. The significance of the anomaly is not clear, but in some cases it might be the reason for development of varicose veins.

Adult↗
PubMed1990

[Chronic venous insufficiency today (a status determination)].

Primary as well as secondary cvi (due to deficiency of the deep venous reflux) is a disease that necessitates a thorough therapy planning and a life-long medical care. Neither operation nor sclerotherapy alone can cure these patients. Active measures must always be combined with conservative procedures such as individually manufactured pressure gradient stockings, occasional intermittent medical treatment of complications and careful guiding of the patients over many years. The first measure is of course a careful establishment of the diagnosis by clinical examination and modern technical methods such as Doppler ultrasound, plethysmography and, in selected cases, phlebography. The therapy concept must consider the advantages and disadvantages of the various methods. A combined treatment in team work with the vascular surgeon may be the starting point, but must always be followed by an intensive life-long guidance of the patients with additional treatments according to necessity.

Humans↗
PubMed1990

[Mucoid cystic adventitial degeneration of the popliteal artery with simultaneous arteriosclerosis].

A 56-year-old male patient presented with intermittent claudication due to cystic adventitial degeneration of the popliteal artery. In addition independent symptomatic arteriosclerotic alterations of several arteries distal and proximal of the popliteal artery were detected. The etiologic, diagnostic and differential-diagnostic aspects in general and the therapeutic implications of this uncommon case are discussed.

Arterial Occlusive Diseases↗
PubMed1989

[10 years of percutaneous disk surgery: results and developments].

The percutaneous nucleotomy via discoscopy for decompression of lumbar disk-prolapse is advantageous regarding segmental stability, is less invasive and can be performed in regional anesthesia. Preoperative evaluation of indication is important. Experiences with 148 patients operated 1979-1988 are reviewed. Immediate success was achieved in 70% (overall 85% favorable results). As further development the novel technique of percutaneous intercorporal spondylodesis is presented.

Anesthesia, Conduction↗
PubMed1989

[An unusual cause of gangrene: cold injury caused by liquid nitrogen].

A case is described of gangrene of the foot and lower leg due to cold injury following exposure to liquid nitrogen. The severe damage to the entire microcirculation was followed by irreversible ischemia finally requiring amputation of the lower leg. Histology revealed conspicuous lesions of the small vessels within the entire soft tissues, with subsequent thrombotic occlusion and circulatory blockade. Some recommendations concerning occupational exposure to liquid nitrogen are added.

Accidents, Occupational↗