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Biomedical subjects

H J Milstein

Publications and source records attributed to H J Milstein.

12 recordsLinked to original sources

Response of hand dermatitis to a new skin barrier-protectant cream.

Twenty-five patients with hand dermatitis participated in a pilot study utilizing a new skin barrier cream containing white petrolatum. Each patient received treatment with SBR-Lipocream, which was applied three to four times daily for a period ranging from one to four weeks. All patients completed pre- and postsurvey questionnaires and were evaluated by a staff physician prior to, and upon completion of, the study. All patients completed the evaluation. Results of the survey indicated a general dissatisfaction with currently utilized moisturizers and a positive response to the skin barrier cream: 96 percent believed that this cream helped their condition. Based on this response, further evaluation of this cream's ability to manage this often-chronic condition and prevent exacerbation and flares appears warranted.

Adolescent↗

Basal cell carcinoma of the scrotum.

Basal cell carcinoma is the most common human neoplasm, with hundreds of thousands of new cases occurring on an annual basis. Involvement of the scrotum is quite rare, with fewer than twenty-five reported cases. We present a patient with a basal cell carcinoma of the scrotum and review the literature regarding this infrequently documented site.

Aged↗

Resolution of disseminated granuloma annulare following isotretinoin therapy.

Disseminated granuloma annulare is often a chronic disorder that may prove refractory to treatment and lead to prolonged cosmetic disfigurement. In a patient with disseminated granuloma annulare that was unresponsive to multiple therapeutic regimens, administration of isotretinoin resulted in rapid clearing of nearly all lesions. To our knowledge this is the first reported case in which this agent was used to treat disseminated granuloma annulare.

Female↗

Home ultraviolet phototherapy of early mycosis fungoides: preliminary observations.

Thirty-one patients with early mycosis fungoides (MF) and three patients with parapsoriasis en plaques were treated with ultraviolet phototherapy (280 to 350 nm) at home using a commercially available light source containing four Westinghouse FS40 lamps. A complete clinical and histologic remission of disease, lasting for a median duration in excess of 18 months, was achieved in nineteen patients (61%) with MF. Although higher complete response rates generally are achieved with other therapeutic modalities, ultraviolet phototherapy with its minimal adverse effects may be indicated for selected patients. Controlled studies are encouraged to evaluate the full potential of conventional phototherapy in the management of MF.

Adult↗

Chronic herpes simplex infection in cutaneous T-cell lymphomas.

Therapeutically unresponsive erosive or ulcerative lesions caused by the herpes simplex virus developed in five patients with advanced cutaneous T-cell lymphoma. The chronic progressive character of the herpetic infection probably was the consequence of immunosuppression resulting from advanced lymphoma or its treatment. Herpes simplex infection should be considered in the differential diagnosis of cutaneous ulcerations in patients with cutaneous T-cell lymphomas.

Aged↗

Serum bile acids in alcoholic liver disease. Comparison with histological features of the disease.

Fasting serum bile acids were measured by gas-liquid chromatography in 64 patients with alcoholic liver disease and compared with histological features in their percutaneous liver biopsy specimens. Total bile acid concentrations were normal (less than 2 mug/ml) or minimally increased in 6 patients in whom fatty infiltration was the only hepatic lesion. In the remaining 58 patients with more severe histological lesions, levels were increased in 93%, whereas serum bilirubins were elevated in only 43%. Chenodeoxycholic acid was usually the predominant serum bile acid, regardless of the degree of necrosis or connective tissue change in the biopsy specimen. Only small amounts of the secondary bile acids, deoxycholic acid and lithocholic acid, were detected. Levels of these secondary bile acids did not correlate with histological features.

Alcoholism↗