PubMed Health⌕ Search

Biomedical subjects

H J Rall

Publications and source records attributed to H J Rall.

5 recordsLinked to original sources
PubMed1981

Effects of four prostaglandin analogues on menstrual cycle length and peripheral levels of 17 beta-oestradiol and progesterone in the chacma baboon.

Four different prostaglandin analogues were studied with regard to their effects on menstrual cycle length and peripheral in th chacma baboon (Papio ursinus). Pooled data showed that the luteal phase was shortened by more than 4 days and that both hormone levels were reduced significantly after treatment. In terms of the inhibition of progesterone production as an absolute index of corpus luteum function, PGF2 alpha, 1,15-lactone, and 11 alpha (15S)-17-phenyl-ent-18-19,20-trinor-PGE2 methyl ester were found to be the most effective luteolytic compounds.

Animals↗
PubMed1979

Comparison of the lytic effects of four prostaglandin analogues in the chacma baboon (Papio ursinus ursinus).

Six healthy, cycling female chacma baboons (Papio ursinus ursinus) were used to determine the luteolytic effects of four prostaglandin analogues. The compounds were administered according to a study design which made provision for adequate controls. Five to seven days following ovulation, venous blood was collected and the baboon given a single intramuscular injection of a compound at a recommended dose. Blood was then collected serially every 3 h for three samples and again at 24, 48, and 72 h to determine the continued effect of the prostaglandin analogues on corpus luteum production of progesterone. It was found that PGF2alpha-1,15-lactone, 11alpha(15S)-17-phenyl-18,19,20-trinor-ent-PGE2 methyl ester and 17-phenyl-18,19,20-trinor-PGF2alpha exhibited definite luteolytic potential in this species. Equivocal results were obtained with (15S)-15-methyl-PGF2Alpha THAM and its toxic qualities resulted in the demise of three animals.

Animals↗
PubMed1978

Effect of medroxyprogesterone acetate contraception on cytoplasmic estrogen receptor content of the human cervix uteri.

Specimens of cervical tissue from five women each on 150 mg and 450 mg regimens of medroxyprogesterone acetate (MPA) for contraceptive purposes, were obtained through punch biopsy 15 days after injection. In another group of five women each on the same contraceptive regimens, punch biopsies of the cervix uteri were obtained 30 days after injection. These times corresponded to maximum and optimum blood levels of MPA respectively. Corresponding tissue from the same anatomical position in patients matched, where possible, for age and parity was obtained from hysterectomy specimens to serve as controls. Quantification of estrogen receptor content in the cytoplasm of these tissues was achieved through standard procedures. Analysis of data showed that MPA suppressed estrogen receptor content significantly compared to controls, but that there were no differences in this effect between the two dosages or time of biopsy.

Adult↗
PubMed1977

Comparative contraceptive experience with three-month and six-month medroxyprogesterone acetate regimens.

Three-month (150 mg) and six-month (450 mg) contraceptive regimens of medroxyprogesterone acetate (DMPA) as an intramuscular depot injection are compared in this paper. A total of 19,875 women participated in the study, accounting for 220,530 woman-months of use. A Pearl index of 0.1069 for the three-month regimen was significantly lower than for the six-month group, where the index was 0.4943 (p less than 0.01). Side effects were limited insofar as personal reasons and loss to follow-up were the most important single category for discontinuation of this contraceptive method. No thrombotic incidents occurred. It is concluded that both contraceptive regimens of DMPA appear to be acceptable with regard to use-effectiveness, patient acceptance and prevalence of side effects.

Adolescent↗