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Biomedical subjects

H J Robb

Publications and source records attributed to H J Robb.

At least 19 recordsLinked to original sources
PubMed1997

A two-layer "telescoping" proximal anastomosis for repair of juxtarenal abdominal aortic aneurysms.

A two-layer proximal aortic anastomosis for juxtarenal abdominal aortic aneurysm resulting in satisfactory "match" between Dacron graft and aorta is obtained. With this technique we are able to avoid additional suture and carotid bleeding from the suture line. Follow-up aortograms and computerized tomography of the aorta have shown complete exclusion of aneurysmal portion of juxtarenal aorta.

Anastomosis, Surgical↗
PubMed1992

Endarterectomy with arterial dilators: surgical technique.

A simplified technique of semi-closed endarterectomy with arterial dilators that insures complete removal of intimal fragments was used by the authors. Complications, such as arterial wall penetration and residual intimal fragments, are reduced. This technique has proven useful in aortoiliac and short-segment femoral artery endarterectomy. It is also helpful for proximal anastomosis of femoral/popliteal/tibial in situ bypass where termination of saphenous vein cannot reach femoral artery.

Arterial Occlusive Diseases↗
PubMed1978

Plasma ADP levels: direct determination with luciferase luminescence using a biometer.

A method is described for the determination of low plasma levels of adenosine-5'-diphosphate (ADP) using a Dupont Biometer to measure luminescence produced by the luciferin-luciferase reaction. Endogenous ATP is removed by incubation with luciferase. The remaining ADP is then quantitated, following its conversion to ATP, after incubation with creatine phosphate and creatine kinase. The mean coefficient of variation for 0.02 and 2.2 micromol/liter ADP standards were 2.1 and 1.8% respectively. The method has been applied to human and rabbit plasma. Human plasma ADP concentrations were found to be 0.13 +/- 0.025 (10) micromol/liter and rabbit plasma concentration were 0.07 +/- 0.05 (5) micromol/liter. Several other possible applications of the method are discussed.

Adenosine Diphosphate↗
PubMed1978

Clinical experience with surgical treatment of chronic intestinal ischaemia.

Fourteen patients suffering from abdominal angina have been operated on with different revascularization techniques. Preoperatively all of them had classical symptoms: postprandial pain and all except two had remarkable weight loss. There were six patients with isolated coeliac axis stenosis and in eight cases there were two or three diseased vessels. Liberation and reconstruction of the coeliac axis were carried out in six cases. Aorto-hepatic by pass graft was performed in three patients. Reinsertion of SMA was done in four and reinsertion of IMA in one case. Reconstruction of SMA with a by pass graft was carried out also in one case. There was no operative mortality. One of the patients died five weeks postoperatively at home from myocardial infarction. Another patient operated on in 1965 died seven years later at the age of 78 from myocardial infarction. He had had no further symptoms of abdominal angina postoperatively. The remaining 12 patients were relieved of their symptoms after the operation. They have been followed up for a mean of 5.5 years. The good long term results of arterial reconstructions in contrast to the poor prognosis without operation, favours early operation. The importance of early diagnosis and the importance of early operative treatment are emphasized.

Adult↗
PubMed1977

Microdetermination of plasma ATP and creatine phosphate concentrations with a luminescence biometer.

We optimized conditions for determination of adenosine-5'-triphosphate (ATP) and creatine phosphate from plasma extracted with ethanol/water (96/4 by vol). The procedures utilize the firefly luciferin/luciferase reaction, the bioluminescence being measured with a Du Pont Biometer. ATP is quantitated directly and creatine phosphate is quantitated by reaction with creatine kinase and ADP, after plasma ATP is removed by incubation with the enzyme apyrase. The method is applied to plasma from humans, rabbits, and rats, and possible clinical applications are discussed.

Adenosine Triphosphate↗
PubMedDate not supplied

Plasma changes in endotoxin and anaphylactic shock (ATP, ADP and Creatine phosphorus).

Decisive patterns have been demonstrated in plasma adenosine 5' triphosphate (ATP) levels in both endotoxin and anaphylactic shock which correlate with periods of low platelet counts, low arterial pressures and abnormal electrocardiograms. When these irregularities were occurring, the plasma ATP level was low; when improvement occurred, the plasma ATP level rose. Plasma ATP levels appear to be an index to the metabolic state of the animal. The plasma creatine phosphate (CP) level showed a tendency to decrease when the ATP level dropped in anaphylactic shock, although the CP level did not recover to the same extent as the ATP level. In endotoxin shock, the plasma CP level increased on an average of six-fold. It is proposed that this rise resulted from either CP mobilization from tissues, for the purpose of replenishing the energy deficient myocardial muscle, or possible leakage from damaged cells. Adenosine diphosphate (ADP) plasma values were measured in both anaphylactic and endotoxin shock. High initial ADP values were prone towards a more severe anaphylactic reaction and a shorter survival time in the endotoxin shock experiments.

Adenosine Diphosphate↗
PubMedDate not supplied

Comparative study of blood clotting factors in anaphylactic and primary and secondary endotoxin shock.

Cinephotomicrography shows emboli are formed in the lung during stages of anaphylactic and endotoxin shock and platelet counts are decreased. Rabbits in anaphylactic shock had a 50 percent mortality while 100 percent mortality was associated with endotoxin shock. During the terminal phase, the platelet count recovers in anaphylactic shock but not in endotoxin shock. This suggests a difference in the emboli formed during these two forms of shock. This study was directed at determining what might be the difference. Periodic measurement of electrocardiographic tracings, fibrinogen, factor VIII and fibrin degradation products (FDP) were made using standard equipment and test kits. The results of the study showed no changes in any of the measured clotting factors during anaphylactic shock. However, in endotoxin shock FDP appeared after seven to 10 hours, fibrinogen levels decreased from 221 mg per dl to 85 mg per dl and factor VIII time increased significantly. From these results, it is concluded that platelet aggregation in anaphylactic shock does not involve fibrin deposition, whereas in endotoxin shock platelet aggregation and fibrin deposition are both a factor in the formation of the emboli, possibly explaining the irreversible aggregation observed in terminal endotoxin shock.

Adenosine Diphosphate↗