PubMed Health⌕ Search

Biomedical subjects

H J Schneider

Publications and source records attributed to H J Schneider.

At least 19 recordsLinked to original sources
PubMed1979

[The effect of chronic renal insufficiency with and without dialysis therapy on the manganese content of various human organs].

On the basis of the organ values of nine decreased, formerly with Al (OH)3 treated patients with renal insufficiency without dialysis and 15 patients with dialysis their Mn-state was investigated in comparison to 60 control persons comparable as to age and sex. The dialysis patients for a considerable part died of the so-called dialysis encephalopathy three to five years after the beginning of the Al-treatment. In all investigated nine organs with the exception of the blood of the dialysed patients (liver, hair of the head, myocardium, brain, rib, lung and testicle) the Mn-content was, in comparison to the control persons, essentially, partly highly significantly reduced. These findings were discussed in various kinds of animals in connection with the skeletal and nervous disturbances conditioned by the Mn-deficiency. It may not be excluded that the Al-hydroxyde used for the phosphate binding protects also another essential trace elements and particularly Mn from resporption and has an antagonistic influence on the Mn-metabolism, respectively. Animal experiments must clarify the complex mentioned.

Age Factors↗
PubMed1979

[Investigations on formation risk of calcium oxalate stones with special regard to stress (author's transl)].

Concentrations and excretion of ten urine parameters were recorded in defined urine portions of 20 calcium oxalate stone patients and 10 normal subjects; some of these urine constituents show a day-night rhythm thus indicating a daily risk variation. From the analysis of questionnaires on physical strain and psychonervous stress, correlations between stress and urine substances can be established. In this connection, oxalic acid concentration and excretion seem to be of special importance. The obtained results provide the basis for further complex-chemical calculations.

Adult↗
PubMed1979

Investigations on flow dynamics and microstructure and their contribution to urolith genesis.

Stones originating in the tubular system may grow in the renal calyces without being excreted. From the analysis of flow dynamics nearly steady turbulences with long retention times should be expected, in which particles with a density of about 1.0 can grow. By this, hydrodynamics would support the matrix theory of stone genesis. Microscopic structures of the central stone regions also support 'organic early stages in urolith genesis.'

Humans↗
PubMed1979

Hemocyanins in spiders, VI[1]. Comparison of the polypeptide chains of Eurypelma californicum hemocyanin.

The subunits of the hemocyanin from the tarantula, Eurypelma californicum, were isolated, following dissociation at pH 9.6, by a sequence of chromatographic and electrophoretic steps. Fraction 2 (containing two chains, a and c2) and the constituent polypeptide chains of the dimeric subunit 4D (b and c4) were resolved by anion exchange chromatography at pH 8.9 and 6.5, respectively. Since c2 and c4 have different electrophoretic mobilities in polyacrylamide gradient gels, the total number of different polypeptide chains is seven. The amino acid compositions of the seven chains are reported. There are major differences for at least half of the amino acids, while more consistent proportions become evident, if the amino acids are grouped by types of side chains. The N-terminal amino acid is proline in the case of chains b and e,, while no end group called be detected in any of the other chains by different methods. The C-terminal end group was found to be valine in both chains d and e. Cleavage by 70% formic acid, and by cyanogen bromide in formic acid results in fragmentation patterns distinct for each chain. After cyanogen bromide cleavage, the two largest peptides of each chain are of molecular weight near 2400. Tryptic fingerprints also reveal significant differences between all chains. Subunit heterogeneity of Eurypelma hemocyanin is clearly not the consequence of secondary modifications, but resides in major differences of the amino acid sequences.

Amino Acids↗
PubMed1979

Hemocyanins in spiders, VII. Immunological comparison of the subunits of Eurypelma californicum hemocyanin.

The isolated subunites of Eurypelma californicum hemocyanin were studied by aid of antibodies raised against whole, dissociated hemocyanin. The proportion of impurities was found to be low in almost all subunits. There was no cross reaction between the individual chains, and the total number of antigenically different subunits was found to be seven, confirming results obtained by different methods. If an artificial mixture prepared from purified subunits is compared to whole, dissociated hemocyanin, an overall very similar pattern is obtained but differences appear which are due to specific interaction.--The dimeric subunit 4D was shown to be a heterodimer (asymmetric dimer) composed of chains b and c4.

Animals↗
PubMed1979

[Effect of drugs used for the prevention of urinary calculi recurrence on the growth and metabolism of young experimental animals].

In the animal experiment should be made clear whether several medicaments which stood the test in the prevention of relapses of urinary calculi may be used without any danger also in the infantile carrier of concrements. For this purpose young rabbits high doses of diuretics, kation exchangers, aluminium oxide, extracts of the root of rubia tinctorum, succinimide and diphosphonate were given. Growth and development of the animals were negatively influenced by the medicaments, with the exception of the kation exchanger and the extracts of the root of rubia tinctorum. Numerous animals died under the administration of duiretics. The results of the examinations of metabolism only partly allow general conclusions. The medicamentous long-term metaphylaxis of the urolithiasis in childhood is also to be used like dietetic restrictions under strong indication and permanent control.

Aluminum Oxide↗
PubMed1979

[Metabolic studies during urinary diversion by way of the small intestine].

Examinations of the metabolism were carried out in 23 patients with ileal conduit and undisturbed renal function, in order to recognize the causes of stone-formation. In the infection calculi they are given with the alkaline urine, when an infection and a urinary retention is present. Perhaps the Ca-oxalate calculi develop within the hyperoxaluris in connection with a reduced citrate urine concentration. Differences in the composition of the conduit and renal pelvis urines could be proved.

Calcium↗
PubMed1979

[Somatic parameters in patients with urinary calculi and their relationship to age, sex and kind of calculus].

In the present investigation in 515 carriers of nephroliths (311 males and 204 females) age, sex, type of constitution, body weight, physical load and blood pressure are set in relation to the various kinds of calculi. Here it was revealed that males more frequently fall ill with nephrolithiasis than females, that there exist certain age peaks, the pycnic typ of constitution preferredly appears in female carriers of calculi and the athletic type in male ones, the majority of all examined patients had in comparison to the normal an increased body weight, and a very large proportion of persons with only insignificant physical load is found among the carriers of calculi. The result of the relations of blood pressure was that only half of all patients with urolithiasis examined had a normotonic blood pressure.

Age Factors↗
PubMed1979

[The long-term effect of various hormonal contraceptives on the excretion of sodium, potassium, calcium, magnesium, chloride, phosphorus, uric acid, oxalic acid, citric acid, sulfate and lysozyme in the 24 hour urine].

The influence of a long-term application of 4 different hormonal contraceptives on the excretion of various constituents of the urine was examined. A reverse effect after stoppage of the medication is to be established in none of the other parameters with the exception of calcium.

Calcium↗
PubMed1978

[Experimental studies on the effect of long-term oestrogens on contrast excretion during intravenous urography (author's transl)].

The possible connection between long continued oestrogen intake and dilatation of the upper urinary tract was examined urographically in nine female rabbits. The degree of dilatation was judged on eleven parameters. The results of the study indicate that oestrogens without simultaneous mechanical influence on the urinary tract does not lead to dilatation of the pelvis or ureter. The results are illustrated graphically and are compared with the findings in the literature.

Animals↗
PubMed1978

Diastereomeric 7-ureidoacetyl cephalosporins. I. Superiority of 7alpha-H-L-isomers over D-isomers.

The synthesis and in vitro structure-activity relationship of 7-ureidoacetyl cephalosporins carrying various substituents in the 3-position, compounds that showed an enhanced broad spectrum of antibacterial activity, has been outlined. Contrary to most of the previous observations with diastereomeric isomers of cephalosporins, it has been found that the L-side chain isomers also are very potent antibiotics and are even more active inhibitors of certain beta-lactamase-producing Gram-negative bacteria than the corresponding D-side chain isomers. SQ 69,613, 7beta-[[L-[(aminocarbonyl)amino]-2-furanylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl) thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, sodium salt, the most active compound tested, except for activity against staphylococci, was as active in vitro as cefamandole.

Amino Acids↗
PubMed1978

[Analytic experiments on the significance of the fluorine content of urinary calculi (author's transl)].

The fluorine content of 150 precisely differentiated urinary calculi from areas with and without fluoridated drinking water (FDW) was quantitatively determined using different analytic methods. The fluorine content differed according to the type of calculus. With an average of 2 mg/g of calculus substance, the whewellite or weddellite concretions in FDW areas have the greatest portion of fluoride. The degree of crystallization of carbonate calculi increases with increased percentage of fluorine, and the parameter of the reticulum is characteristically contracted.

Apatites↗