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Biomedical subjects

H J Seib

Publications and source records attributed to H J Seib.

At least 19 recordsLinked to original sources
PubMed1997

[Schoenlein-Henoch purpura with intestinal involvement].

A 51-year-old male patient admitted to the hospital because of colic-like abdominal pain, paralytic ileus, anal bleeding and microhaematuria with proteinuria, developed an intestinal ischemia with a serum lactate level of 6.3 mmol/l. An occlusion of the large vessels was excluded angiographically. Perfusion disorders were detected both endoscopically and histologically in the upper gastrointestinal tract and in the terminal ileum. When after two days a palpable purpura appeared on the anterior of both feet, a vasculitis type Schoenlein-Henoch was suspected and treated with high doses of steroids, resulting in decreasing symptoms. From the point of admittance, a nephritic urinary sediment had been apparent, and the renal affliction developed into a nephrotic syndrome without notable reduction in the glomerular filtration rate. On the 13th day of treatment the patient-being on a reduced dose of steroids-suffered from a severe relapse; however, this responded favorably to an increase of the dosage. The kidneys required approximately one year for complete recovery. Based on this case, the Schoenlein-Henoch purpura syndrome and its differential diagnosis are presented, particularly with respect to gastrointestinal symptoms and in view of the pertinent literature.

Abdomen↗
PubMed1994

[Alpha-heavy chain disease--Mediterranean lymphoma].

For 6 months diarrhea and weight loss of 30 kg occurred in a 28 year old man from the Emirates. The endoscopic examination suggested a small intestinal lymphoma affecting the entire small intestine, which was confirmed by biopsies, immunohistochemistry, immunologic proof of monoclonal IgA-gammopathy in serum and urine. The patient acquired a malignant MALT-lymphoma of B-cell-type, a alpha-Heavy Chain Disease, synonym mediterranean lymphoma or immunoproliferative small intestinal disease (IPSID), stage A with transition in stage B. The patient was treated with ciprofloxacine in association with metronidazole with no influence of the course of the disease.

Adult↗
PubMed1991

[Definition of the Barrett esophagus--results of an endoscopic study with biopsy].

There are two different definitions of Barrett's esophagus, a precancerous condition. The first requires circumferentially lining of the lower esophagus with columnar epithelium, the second adds tongue-like projections extending up into the squamous epithelium more than 2 cm. Carcinomas, which develop in a Barrett's esophagus almost ever are associated with metaplasia of the specialized columnar type. Endoscopic-bioptical examinations of columnar lined projections were done with 26 patients altogether. Histologically 8 patients showed metaplasia of the specialized columnar type. These results show that columnar lined projections of the specialized type are part of Barrett's esophagus.

Barrett Esophagus↗
PubMed1991

[Endoscopic biopsy study for staging of reflux esophagitis].

Endoscopy reveals that the lesions of reflux esophagitis are red and white spots and streaks. The red lesions are thought to reflect local inflammatory alterations with or without partial necrosis of the squamous epithelium, while white lesions represent complete necroses of the squamous epithelium with fibrin deposits. Fifty-nine patients with reflux esophagitis and red lesions (n = 23) or white lesions (n = 36) underwent endoscopically controlled biopsy of selected particles. Histologic analysis confirmed the hypothesis that white lesions are nearly always necroses involving all layers of the squamous epithelium with fibrin deposits (and rarely epithelial hyperplasia), while red lesions are caused by local granulocytic inflammation or granulation tissue with partial reepithelialization. These results suggest that reflux esophagitis Savary Stages I and II can be rationally subclassified into reflux esophagitis with red spots (Stage Ia), white spots (Stage Ib), red streaks (Stage IIa), and white streaks (Stage IIb).

Biopsy↗
PubMed1987

[Flat tubulovillous adenoma in the duodenal bulb].

Yet within the last years adenomas were described in the duodenum, which are frequently found in the colon. The incidence of the lesions in the routine endoscopy of the upper GI-tract was estimated to be 0.23% for tubulo-villous and 0.86% for all adenoma. This case report describes an unusual flat tubulovillous adenoma with cellular atypia covering nearly the whole duodenal bulb which was endoscopically diagnosed.

Aged↗
PubMed1985

Ergotamine-induced colitis.

We report on a 45-year-old woman with ulcerative colitis of the rectum that arose after the use of up to 6 suppositories of a preparation containing ergotamine daily over a period of 6 years. On the basis of a review of the literature the clinical, endoscopic and histological features of the ergotamine-induced colitis are characterized.

Colitis, Ulcerative↗
PubMed1985

Non-Hodgkin lymphoma of the rectum mimicking angioma.

We report on a 52-year-old man who was admitted to hospital for peranal bleeding due to a rectal tumor with the endoscopic aspect of an angioma. The histological work-up revealed a Non-Hodgkin lymphoma of low malignancy (centroblastic-centrocytic lymphoma in the Kiel classification). The lymphoma was staged IE. A short review of the literature is given.

Biopsy↗
PubMed1984

[Duodenal polyps. Incidence, histologic substrate and significance].

378 duodenal polyps were identified by endoscopic biopsy since 1973 in the course of more than 25,000 oesophago-gastro-duodenoscopies, corresponding to an incidence rate of 1.5%. Heterotopias of the gastric mucosa and so-called inflammatory polyps were most frequent (35.7% and 35.2%, respectively), followed by hyperplasia of Brunner's glands (6.9%), lipid islets (2.9%) and lymphatic hyperplasia (1.8%). Histologically there was no correlate to the endoscopic findings. Hence, non-neoplastic polyps account for about 90% of duodenal polyps; they are harmless and generally produce no (or only minor) signs or symptoms. Clinically relevant polyps besides the primary and secondary malignant processes are the adenomas of the colon type (6.9%) and Peutz-Jeghers polyps (1.3%). Since these two may occur in gastrointestinal polyposis, "top-and-tail endoscopy" must be performed. The rate of complications of 15% in endoscopic loopectomy in the duodenum is clearly higher than that in the stomach and colon.

Brunner Glands↗
PubMed1984

[Is gastroscopic polypectomy a diagnostic necessity? Results of a prospective study].

In a prospective study 76 gastric polyps (of 67 patients) were investigated consecutively by forceps biopsy and by endoscopic polypectomy. The results were compared histologically. Differences arose only in the group where focal foveolar hyperplasia had been diagnosed by forceps biopsy. Of these, 33 remained with the same diagnosis on microscopic assessment of the whole polyp, 14 were hyperplasiogenic polyps, 7 fibrous-inflammatory polyps and in one case there were cysts of the glandular body. A clinically relevant difference was observed in only one polyp where biopsy in toto showed a borderline lesion whereas forceps biopsy had only shown focal foveolar hyperplasia. Critical reevaluation of the specimens led to reassignment as focal foveolar hyperplasia and intestinal metaplasia. There were no differences of histology in the group of adenocarcinoma, adenomas and borderline lesions. Thus, endoscopic forceps biopsy of gastric polyps suffices to reliably differentiate benign from malignant polyps including those which are considered precancerous.

Aged↗
PubMed1984

[Papillary fibroelastoma of the aortic valve. Sudden death caused by an uncommon tumor of the heart].

We describe a very rare tumor of the heart with a pendulous papillary fibroelastoma of the aortic valve, obstructing the ostium of the LCA - resulting in the sudden death of a healthy 40-year-old man. Acute severe ischemia was registered in the ECG a few minutes before death - corresponding especially to the myocardial regions perfused by the LCA. There is no doubt from the post mortem findings that the sudden death of this patient was caused by occlusion of the left coronary ostium by the pendulous papillary fibroelastoma.

Adult↗