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H J Soost

Publications and source records attributed to H J Soost.

At least 19 recordsLinked to original sources
PubMed1979

[The effectiveness of cervical cytology screening for cervical cancer (author's transl)].

Cervical cytology screening was performed, between July 1971 and the end of 1976, on 503,870 specimens from 226,428 women. During this period the rate of positive or suspicious findings fell from 2.6% to 0.9%. The number of specimens judged suspicious for invasive carcinoma, carcinoma in situ or with severe dysplasia (among those women who had undergone serial examinations) was 5 per thousand for the first specimen, 2 per thousand for a subsequent second specimen, and 1.6 per thousand for a subsequent third specimen. The screening programme detected (later confirmed histologically) 272 cases of invasive carcinoma and 948 of carcinoma in situ or severe dysplasia. Related to the number of women screended at various ages, the frequency of carcinoma in situ and severe dysplasia had a peak between the 25th and 29th year of life, with a second, lower peak at around the 65th year. For invasive cervical carcinoma the frequency remained high into old age. The proportion of histologically proven cases of invasive carcinoma fell continuously from 1963/66, at 3.6 per thousand, until 1976, at 1.6 per thousand.

Adult↗
PubMed1979

Progress report of the TUDAB project for automated cancer cell detection.

Two methods for high resolution cell image data acquisition are applied routinely. Cells are either scanned by a computer controlled fast scanning microscope photometer (SMP) or a TV-camera. The software system for digital image analysis was completely revised and implemented on the PR 330 minicomputer. The system contains codes for primary cell data acquisition, segmentation of cells, cell feature extraction and statistical cell analysis. With this system, SMP and TV scanned cell data bases of PAP stained cells in vaginal smears, grouped into several classes, have been built up. Each data base contains 34 primary features and 20 feature combinations for each cell. A linear discriminant analysis is applied routinely for cell classification. The present state of the system and its operation are described, cell features and classification results are shown, and future steps for a prescreening strategy are discussed.

Computers↗
PubMed1979

Sedimentation velocity separation: a preparation method for cervical samples.

A preparation procedure, aiming at monolayer deposition of cervical exfoliative material on glass slides for high resolution prescreening has been developed. The main features of this procedure are centrifugal deposition after suspension and sedimentation of samples over isopycnic medium of 1.026 density. Fractioning of the separation column after centrifugation at 50 X g yields two preparations with leukocytes, bacteria and cellular debris predominantly located on the first slide and epithelial cells on the second one. The degree of spatial cellular isolation as well as the amount of diagnostically relevant cells per slide seem to fit the requirements of automated high resolution analysis.

Cell Separation↗
PubMed1979

Cytomorphologic results of preparation experiments for monolayer deposition of cervical material.

For automated prescreening methods by high resolution analysis serving as a detecting method in gynecologic mass screening programs a new monolayer deposition method of cervical material has been used. This method will be outlines briefly and the mode of evaluation as well as current cytomorphological findings will be presented. With regard to measurability of the slides prepared according to the new method a number of cytologic criteria were thought to be of particular importance. These criteria are delineated and compiled in a table. A form in which these criteria were listed was filled in by cytopathologists for each slide evaluated. When performing isolation and centrifugation procedures several new morphologic questions arose to the cytopathologist which can only partly be answered by now. If taking into account all criteria of evaluation it may be followed from the present experiences that slides of cervical material are much more suited for automated prescreening methods by high resolution analysis if prepared after isolation and centrifugation in macromolecular liquids than are conventional Papanicolaou smears or slides from suspensions with isolated cells that were not subjected to centrifugation procedures.

Cell Separation↗
PubMed1978

[Effects of oral contraceptives of cancerogenesis of cervical epithelium (author's transl)].

The question of hormonal action of oral ovulation inhibitor is discussed by means of publications up to the present. Some authors described endocervical hyperplasia, most of these informations were casuistic articles. Without doubt these lesions are benign. Cytophotometric measures of cervix cells of women using oral contraceptive steroids during a long time demonstrate quite normal DNA levels. Statistical comparisons between different groups, based on cytological and partially histological examinations, showed after using different oral contraceptive steroids preponderant high rates or sometimes lower rates of cervical atypia. Only a few examinations showed in comparison to a control gorup higher rate of dysplasia and carcinoma situ of the cervix. These results also were prevalance rates and no incidence rates. The difficulty of critical examination of statistical results is to consider that besides the normal effects of contraceptives many other factors have influence on cancerogenesis of the cervix. Most of all change of sexual behavior may be an important factor. The increased occurrence of cervical atypia as a direct effect of contraceptives could not yet be demonstrated.

Adolescent↗
PubMed1977

[Prescreening methods for gynecological cytology (author's transl)].

In cytological investigations to trace gynecological cancer a large number of preparations must be examined in order to discover a small number of positive and suspicious findings. In 1974, 5.5 million investigations were carried out in the German Federal Republic, of which 2% positive, 9.2% suspicious and 2.4% technically useless cytological results were obtained. 98.64% of the cytological results were negative. Consequently in different parts of the world efforts are being made to automate the preliminary microscopic sampling of the cytological preparations. False negative cytological findings must be no higher than in conventional diagnosis (without extraction error approximately 5%), while false positive cytological findings (in conventional diagnosis less than 1%) may be higher, because they can be classified correctly on subsequent assessment.

Adolescent↗
PubMed1976

[Cytological diagnosis of endometrial carcinoma].

Because of increase of endometrial carcinoma the frequency rate of invasive cervix carcinoma and carcinoma of uterine corpus has been changing in the last ten years and at several places in the world it is approaching 1:1. That shows the importance of early detection of endometrial carcinoma. A summary of cytology diagnostic of normal and pathological endometrium is given. Especially it is pointed to the great difference between the cytomorphical cell criteria of endometrial malignancies dependent on the differentiation grade of endometrial carcinoma. The predominance of cell atypia is found by the undifferentiated carcinoma of uterine corpus whereas the cells of frequently found well differentiated endometrial carcinoma often cannot be differentiated from normal endometrium cells. The observation of cells of endometrial carcinoma in normal cellular samples of cervix and vagina is no more than 60--70 percent; at this rate the endocervical aspiration has the greatest chance of detection. To correct the early cellular diagnosis of uterine carcinoma the appearance of normal endometrium cells by screening must be noticed and each finding at an untypical moment, for example in postmenopause, must be an alarm signal. The different intrauterine aspiration techniques obtained more than 90 percent accuracy in the detection of endometrial carcinoma. This method is qualified for special indications in a limited number of cases.

Adenocarcinoma↗
PubMed1976

[Do cytological criteria exist to determine the correct technique of a cytosmear of the uterine cervix? (author's transl)].

The objective of this study was to determine whether the presence or absence of endocervical and/or metaplastic cells in a pap smear from the uterine cervix is indicative that the smear has been obtained from the correct location. Cytosmears from positive cytological findings were compared with cytosmears from correct negative and false negative findings for the presence of endocervical and/or metaplastic cell types. It was found that smears with positive findings showed no endocervical and or metaplastic cells in 25-30% of the cases of carcinoma in situ or dysplasia and in 75% of the cases of invasive carcinoma. False negative smears contained endocervical and/or metaplastic cells in 50% of the cases, although no atypical or dyskaryotic cells were detectable. The presence or absence of endocervical and/or metaplastic cell types in a cytosmear from the uterine cervix is therefore no indication that the smear has been taken from the correct location.

Carcinoma in Situ↗
PubMed1976

[Transretcat aspiration biopsy in the diagnosis of prostatic cancer (author's transl)].

In almost three years 853 prostatic aspirates obtained from 709 patients were cytologically examined. In 313 patients we also made histological examinations. The cytologic diagnosis could be checked by histology in 288 untreated patients. The cytologic diagnosis of prostatic cancer was confirmed by histology in 65.3% and was false negative in 28.3%. In 6.4% the cytologic material was unsatisfactory for cytologic examination. Considering cytologic findings after repeat aspiration biopsy the accuracy of the cytologic method was 71.7%. The detection rate of prostatic cancer is about 20% higher using both, cytologic and histologic methods, than using cytology or histology, only.

Biopsy, Needle↗