Biomedical subjects
Publications and source records attributed to H J Suschke.
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Eleven children suffering from juvenile spondylitis and reactive arthritis not responding to antiinflammatory therapy were treated with sulfasalazine. Eight patients showed good response, in two patients no improvement was seen and in one therapy was stopped because of side effects. This overall successful result of sulfasalazine therapy of juvenile spondylitis should encourage clinicians to plan controlled trials.
Malignant cells possesses an electric surface charge differing from their healthy counterparts. In many cases they exhibit increased electronegativity. We incubated blood or bone marrow with heparin--a polyanion--and subsequently stained the cells with a fluorochrome. In healthy subjects or patients with non-malignant disease heparin was found to attach closely to the cell surface, visualised through fluorescence. In a variable number of malignant cells heparin did not attach to the cell surface. Electrostatic repulsion of the negative heparin molecule through the increased negativity of the malignant cell is discussed as an explanation of this finding which can be corrected/inhibited by neuraminidase incubation.
Fluorescence staining of white blood cells with Pseudoisocyanine as well as the demonstration of strongly granulated granulocytes after incubation of the blood sample with benzene are the preconditions for the evaluation of the protective effect of glucocorticoids. Glucocorticoids can partly abolish the cytotoxic effect of phospholipase C und endotoxin.
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Drug therapy of juvenile rheumatoid arthritis is discussed. Toward and untoward effects of the basic substances gold, D-penicillamine, chloroquine and azathioprine are presented. The symptomatic management is discussed, the critical points of corticosteroids are emphasized.
An arthritic illness in children may be the expression of quite different underlying conditions. The cause must be searched for by history, clinical examination, and careful consideration of the differential diagnosis. The most important types of arthritis are discussed along with the relevant diagnostic procedures.
A multicentric open clinical trial was carried out by 8 practising specialists in dermatology or paediatrics in patients with bacterial skin diseases who were subjected to a systemic therapy with Syncillin (=Azidocillin). The Syncillin presentation for adults and schoolchildren was tablets of 750 mg each, and sachets of 125 mg or 250 mg for infants. The duration of treatment was 10 days. The parameters analyzed were bacteriological findings and the clinical course of disease. 71 (=74%) of the 96 patients included in this study were considered as cured, 21 (=22%) as improved and 4 patients (=4%) as unchanged. Bacterial identification was still positive in 10 cases after the termination of treatment. However, this did not preclude the assessments of ""cured'' (3 cases) or ""improved'' (7 cases). The tolerance of the preparation was considered as ""very good'' or ""good'' in 91 and as ""poor'' in 5 patients. The most common side effects were nausea and diarrhoea. Exanthema was observed in 2 cases. None of these side effects, however, made a discontinuation of medication necessary. The era of rational and well-directed chemotherapy enables good therapeutic approach also to bacterial skin diseases.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Case report of a young man suffering from seropositive juvenile arthritis who succumbed to the consequences of cerebral vasculitis. Postmortem generalised arteritis was found affecting mainly brain and kidneys. There were no laboratory signs of an inflammatory process during the months before his death nor hypergammaglobinaemia or decrease of complement. The generalised arteritis manifested itself solely as mononeuritis multiplex with eosinophilia. Thus even with discrete signs such as these severe vasculitis ought to be considered for appropriate treatment to be instituted.
Sulfasalazine was used as second line agent in 15 children with different forms of rheumatoid arthritis. In 9 cases amelioration could be achieved with respect to clinical symptoms as well as laboratory parameters. Thus, sulfasalazine can be recommended as basic medication also in juvenile rheumatoid arthritis.