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Biomedical subjects

H J Synowitz

Publications and source records attributed to H J Synowitz.

33 records · Page 2Linked to original sources

[A change in aneurysm surgery--the acute operation].

Patients who have undergone aneurysmal rupture may be endangered by recurrent haemorrhage and consequences of vasospasm. The risk of recurrent bleeding may be ruled out and favourable conditions provided for active treatment of vasospasm by immediate surgical action on a ruptured aneurysm of a cerebral artery. Such action, however, should be taken not later than three days from the event of rupture. Reported in this paper is experience obtained from eleven acute operations in a total of 110 aneurysmal operations over the past seven years. Acute operation is recommended, provided that certain conditions are met.

Acute Disease↗

[Recurrent aneurysmal hemorrhage following establishment of an extra-intracranial microanastomosis].

A report is given on the recurrent haemorrhage of a cerebral arterial aneurysm occurring three days after the establishment of an extra-intracranial microanastomosis by means of a venous transplant. The carotid ligature should be carried out in a second session. The short time interval after the haemorrhage and also the larger flow via the venous bypass is discussed as a possible cause.

Carotid Artery Diseases↗

[Giant aneurysm--manifestations, diagnosis and therapy].

The particularities in the clinical picture, in the diagnostic regimen and in the therapeutic schedule of eleven patients with an aneurysm showing a diameter larger than 25 mm (giant aneurysm) are presented. These aneurysms become clinically manifest as space occupation, as subarachnoid haemorrhage or TIA. 3 false diagnoses in which the aneurysm was mistaken for a cerebral tumour accentuate the necessity of a complete angiographic examination. The computer tomogram yields sufficient information permitting the suspicion of an aneurysm. In 8 patients, the direct aneurysm clipping could be performed; in 2 of them an extra-intra-cranial microanastomosis was established in the same session as a preliminary intervention. The establishment of a microanastomosis was carried out in 2 other patients. After a certain time interval, a carotid ligature (A. carotis interna) in the region of the neck was established in one of these patients. As a purely symptomatic measure for the treatment of the supratentorial pressure hydrocephalus we established a ventricular-atrial drainage in a case of basilar aneurysm. Besides 1 death and 2 severe complications, very good results could be achieved in 5 patients.

Adult↗

[Results of cerebral computer tomography in the diagnosis of tumors of the sella region].

Computer tomography (CT) is an important aid to the diagnosis of sella tumours because it images the tumour directly and delineates it from the healthy tissues. The tumour type can be identified to a certain extent, but angiography is necessary to distinguish tumours from aneurysms. The study is based on 140 surgical and histological examinations, the results of which were compared wit those obtained by CT. Suprasellar inflammations could always be identified by CT. Although intrasellar tumours may be identifiable by CT if full use is made of the potential of the equipment, negative CT results do not necessarily mean that there is no tumour. The diagnostic validity of the method is restricted by the absence of "standards", against which the variable images of intrasellar structures can be judged, and the restricted resolution of CT.

Adenoma↗

[Intraoperative detection of parathyroid tissue by semiconductor electrodes (author's transl)].

With miniature semiconductor electrodes of high sensitivity and special shape it is possible to charakterize diverse tissues during operation. The measured radioactivity of phosphorus reflects its enrichment and storage in the parathyroid tissue. The findings of 5 patients in whom clinically hyperparathyroidism was strongly suspected and who underwent surgery are reported. We have successfully localized parathyroidea adenomas in 3 patients, in 2 cases no adenoma could be found the storage of phosphorus 32 was normal. In all measurements we achieved a complete agreement with histological findings.

Adenoma↗

[Diagnostic classification of intracranial meningiomas in the serial angiogram].

On the basis of 70 serial angiograms of surgically and histologically reliably diagnosed intracranial meningiomas and the appertaining general radiographs of the skull the following was found: 48.5 per cent of the general radiographs showed reactions, 7.1 per cent showed tumour calcifications. Basal meningiomas of the anterior and medium cranial fossae and meniogiomas of the wings of the sphenoid bone are supplied by the a. carotis interna, that is to say, they are also diagnosed by the internal carotid angiography. In serial angiograms, classification was possible in 74 per cent. The other supratentorial meningiomas require angiographies of the external or the common carotid. Infratentorial menigiomas were diagnosed in 50 per cent of the angiograms. The "early vein" is no reliable sign of malignity of the menigiomas. The same applies to "apthologic vessels", "shunts", etc. Staining does not give any secure indications of histological structures.

Cerebral Angiography↗

[Meningiomas from the clinical viewpoint of first symptoms, duration of anamnesis and neurologic-ophthalmologic deficiency symptoms].

UNLABELLED: First symptoms, period of case history, neurological findings and ophthalmological findings were evaluated in 123 patients operated on because of meningiomas. Typical first symptoms were headache (42%), fits (30%) and impaired vision (28%). 70 per cent of the patients showed a case history period of up to two years, 11 per cent one of more than five years. In 25 per cent this period was less than six months. In two cases the symptoms set in an acute form. Paresis was found in cases of meningiomas of the falx convexity region. A papilledema was found in 41 per cent, reflex differences in 30 per cent and hemiparesis in 13 per cent of the patients. LOCATION: parasagittal (28 patients), falx (10 patients), convexity (31 patients), tentorium (6 patients), posterior cranial fossa (4 patients). Neither a short period of the case history nor the absence of neurological and ophthalmological changes can exclude a meningioma.

Adult↗

[Possibilities for error in the diagnosis of craniopharyngiomas].

Age of affection, preferential seat, clinical picture and instrumental diagnosis of craniopharyngiomas are discussed on the basis of 30 observations. Although childhood and adolescence are the leading age groups, there also was a 64-year-old patient. Three courses of the disease were selected: a 6-year-old girl presented both clinically and by instrumental examination indications of a cerebellar tumour; a mandarin-sized arachnoid cyst near the midline was removed. One year later, a suprasellar craniopharyngioma of the size of a chestnut was removed subtotally. Retrospectively, the arachnoid cyst was only seen as a side-finding. A 13-year-old girl showed angiographically and in the pneumoencephalogram signs of a cerebellar tumour located in the middle; the operation showed regular conditions. Only frontal trepanation showed a plum-sized cystic retrochiasmal craniopharyngioma. Similar conditions were found in another 6-year-old girl.

Adolescent↗

[Secondary anemorrhea in processes in the sella region].

The authors report on 36 patients suffering from a tumor in the chiasm-sella-turcica region and their symptoms. The secondary amenorrhea and the disturbances of cycle are the first symptoms in 19 women from altogether 26 women in the stages of live from 14 to 50 years. It is commendable to take the expansive intracranial process in the chiams-sella-turcica region into consideration by the statement of the differential diagnosis of the secondary amenorrhea.

Adenoma, Acidophil↗