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Biomedical subjects

H J Weber

Publications and source records attributed to H J Weber.

31 records · Page 2Linked to original sources
PubMed1977

Studies on sodium ion retention and antidiuretic effects after administration of L-tryptophan to rats.

Under certain conditions the i.p. injection of L-tryptophan leads to a reduction of elimination of Na+. At the same time, the fractional Na+ -reabsorption increases. No increase in the absolute tubular sodium transport rate was observed since the significantly reduced plasma-sodium concentration leads to a decreased sodium load. The most probable cause of a decreased plasma-sodium concentration seems to be a retention of sodium-free water under the chosen conditions of infusion. The water retention is compatible with the antidiuretic effect of 5-hydroxytryptamine.

Animals↗
PubMed1977

[FGX 70% as an energy carrier in severe heart failure].

A case of decompensated heart failure due to a combined myocardial malformation is presented, in which intravenous nutrition with restricted fluid intake became necessary. Employing a 70% solution of FGX combined with an amino acid solution following the KE pattern the already catabolic metabolism was reversed and a loss of weight avoided. Over a long-term period of application (three weeks) no side effects due to this solution were noted. The necessity of continuous supervision of the FGX 70% infusion is stressed.

Adolescent↗
PubMed1975

Inhibition of gluconeogenesis in rat renal cortex slices by metabolites of L-tryptophan in vitro.

The inhibitory effects of metabolites of L-tryptophan on gluconeo-genesis in rat renal cortex has been established. 1. Glucose production was inhibitied by quinolinate in vitro. The inhibition is due to the decreased phosphoenolpyruvate carboxykinase activity. As suggested for purified enzyme systems, quinolinate seems to exert its action in tissue slices by chelating divalent metal ions. The minimum effective extracellular concentration of the inhibitor was 5 X 10(-5) M with pyruvate as a precursor for gluconeo-genesis. 2. The effect of 3-hydroxyanthranilate is stronger (minimal effective concentration 10(-5) M) than that of quinolinate. 3-Hydroxyanthranilate may be effective in its original form and/or as a dimer degrandation product. The compound(s) exert a second effect in addition to blocking the phosphoenolpyruvate carboxykinase. This block is attained by conversion of 3-hydroxyanthranilate to quinolinate. The non-quinolinate mediated effect may be due to a reduced ATP regeneration. 3. It is suggested that kidney cortex responds sensitively to disturbances in ATP metabolism by reduction of glucose synthesis, when it is not the result of blocked formation of phosphoenolpyruvate.

3-Hydroxyanthranilic Acid↗