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Biomedical subjects

H JACKSON

Publications and source records attributed to H JACKSON.

At least 19 recordsLinked to original sources
PubMed1964

PRODUCTION OF HERITABLE PARTIAL STERILITY IN THE MOUSE BY METHYL METHANESULPHONATE.

Partial sterility, in the sense of reduced reproductive capacity, has been demonstrated in the F(1) progeny of male mice mated in the second week after a single dose of methyl methanesulphonate (50 mg/kg, intraperitoneally) with females of proved fertility. Sterility, both partial and complete, was encountered in the F(2) generation obtained by mating F(1) males and females with fertile partners. These results show that the compound, in a substerilizing dose, is capable of producing transmissible genetic damage. It is suggested that the procedure used is a practicable method of testing drugs for possible genetic effects.

Animals↗
PubMed1963

THE EFFECT OF CERTAIN ETHYLENEIMINES ON RENAL FUNCTION.

Certain simple derivatives of ethyleneimine cause an intense and prolonged diuresis in nonhydrated rats. Sodium, potassium and chloride excretion is unaffected by these compounds. Ethyleneimine also causes a diuresis in the rat, but the polyfunctional compound thiotepa is ineffective. The relationship between structure and activity of a number of compounds is discussed with particular reference to the possibility that the diuresis is due to the in vivo liberation of ethyleneimine.

Antineoplastic Agents↗
PubMed1963

METABOLIC STUDIES WITH DI(AZIRIDIN-1-YL) SULPHOXIDE (DIETHYLENEIMINOSULPHOXIDE).

The work described was undertaken after the observation that the diuresis induced by several derivatives of ethyleneimine could be correlated with their content of ethyleneimine. The preparation of (35)S-labelled di(aziridin-1-yl) sulphoxide (diethyleneiminosulphoxide) is described together with its metabolism in rat, mouse, rabbit and dog. The drug was completely metabolized in all species and, with the exception of the dog, most of the activity was excreted in the urine within 3 days. The main radioactive metabolite in all species was sulphate. In vitro studies demonstrated that the compound was slowly broken down to sulphite and free ethyleneimine; this hydrolysis was greatly accelerated in the presence of phosphate.

Animals↗