Biomedical subjects
Publications and source records attributed to H Jacob.
The case of a 72-year-old female with a retroperitoneal abscess which contained cholesterol gallstones is presented. The pathogenesis of this unusual complication of gallbladder disease is discussed.
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We have recently seen two cases of propranolol poisoning. In both instances, plasma propranolol levels were elevated. Both patients experienced generalized seizures and had a transient intraventricular conduction defect on electrocardiogram. The literature on intoxication of propranolol and other beta-adrenoceptor blocking drugs suggests that the effects of massive propranolol intoxication observed in our patients can be explained on the basis of the pharmacologic properties of propranolol. Therapy consisted of gastric lavage and agents to antagonize the beta-adrenoceptor blockade effect. Both patients recovered.
The radiographic spectrum of emphysematous cholecystitis can be divided into three stages. Diagnosis on plain abdominal film is difficult in the first stage. Two cases are presented in which a circular gas filled structure in the right upper quadrant led to a correct diagnosis in the earliest stage. This was confirmed by obtaining contrast studies to rule out other etiologies.
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An acute deterioration of the renal function after injection of (diiodized) renal contrast media in patients with multiple myeloma was pointed out for the first time by Bartels et al. (1954). Since then only a few similar cases have been reported. Therefore in a retrospective study the records of 89 patients with multiple myeloma from 1959 to 1974 were evaluated. For 31 of these patients a total of 41 i.v. pyelographs was made. Corresponding to a previous study by Vix in none of our patients who underwent pyelography a reduction of renal function was observed in direct association with the administration of contrast media. We are in agreement with other authors that a recognized myeloma is not from the first a contra-indication for the application of contrast material containing iodine so as a dehydration of the patients can be carefully avoided.
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Amyloidosis has not been included in the wide spectrum of medical complications associated with drug abuse. Chronic visceral infection is a recognized cause of amyloidosis, but chronic suppuration of the skin is not a well-appreciated cause of this condition. Furthermore, to our knowledge, chronic skin suppuration secondary to parenteral drug abuse has not been reported as a cause for systemic amyloidosis. We report a case in which subcutaneous injections of narcotic tablets led to chronic skin suppuration and systemic amyloidosis.
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The neurobiological sciences deal with morphological, physiological, biochemical, and pharmacological investigations of neurobiological processes and mechanisms. In addition, they are interested in living organisms as action systems, with their forms of motion, types of behavior, and means of adapting to the environment. The topic "The Neurobiology of the Successive Stages of Life" covers the entire span of life, from the induction of the neural tube to senescence and death, i.e. the sum total of all continuous changes which are described by such terms as development, differentiation, specialization, individuation, functional maturity, and ageing. The following gives a survey from a special neurological-neuroanatomical point of view, it deals with the early development of prenatal activities, forms of movement, and refled differentiation cycles in regard to neurofibrillation, myelination, and cytological-cytoarchetectonic structures. Paul Yakovlev's and Peter Kuzmich Anokhin's interpretations of such selective morphological-functional maturation processes inherent in the system are discussed. There follows a brief survey of varying metabolic systems in close connection with the differentiation of nerve and glia cells and capillarization processes. The subject of early programmed cell death, nerve-cell degeneration, and heterotopia during the development, differentiation, and maturation of the central nervous system leads to a discussion of the likewise selective system-bound processes that take place during senescence of the central nervous system.
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