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Biomedical subjects

H Jakobi

Publications and source records attributed to H Jakobi.

7 recordsLinked to original sources
PubMed1978

[Results of treatment of the cancer of the larynx at the ENT-University-Clinic, Halle/Saale, 1940 to 1969 (author's transl)].

The treatment-surgery and irradiation- of 722 patients with cancer of the larynx in the years 1940-1969 are being statistically evaluated. The classification was done accordingly to localisation, stage (TNM-system) and the kind of therapy. The evaluation of the results only considers the 5-years-healing. Surgical therapy and primary irradiation were confronted. The irradiation ranks equally to surgery only at stages I and II of the carcinoma of the vocal cords. Tumors at other localisation or at a different stage (III and IV) can only be successfully treated by surgery.

Germany, East↗
PubMed1977

[Statistics on 1231 patients with cancer of the larynx 1940 to 1974 (author's transl)].

At the ENT-Univ. Clinic Halle/Saale 1231 patients suffering from an histological verified cancer of the larynx have been observed over the last 33 years. The numbers of male cases have been trebled within the last 30 years. This trend could not be observed in women. The increase is connected with a remarcable concentration of the supraglottic localisation. Despite of intensive information of the population most of the patients only turn to our clinic in the stage II and III (TNM-system). Only in 9.9% of the cases their fate remained unknown.

Adult↗
PubMed1975

ATP-atp.

It has been known for some years that intra-arterial application of ATP as well as the only treatment with hyperbaric Oxygen is able to influence favorably a sudden hearing loss. In this study the combined application of both agents was used optimally. Up to now only few cases could be treated. The three above mentioned patients have shown remarkable results. A patient with a long lasting sensorineural hearing loss is especially interesting and this is the reason why we now publish the results gathered up to now.

Adenosine Triphosphate↗
PubMedDate not supplied

[Clinical and experimental use of ATP in internal ear diseases].

Intra-arterial ATP infusions with glucose and hyaluronidase were successful in 267 patients suffering from various inner ear disturbances but particularly in sudden deafness. Good clinical results were noted not only in early-treated but also in later cases. Recently, we have also used ATP with hyperbaric oxygen, being successful in cases which were previously treated without improvement. Investigations in guinea-pigs, using artificial hypoxia as a model for human sudden deafness failed because the patterns are not the same. So long as an increase of ATP in the cochlear cells cannot be demonstrated after the i.a. infusions, only an unspecific mechanism can be held responsible for the undoubted clinical successes.

Adenosine Triphosphate↗
PubMedDate not supplied

[Standardized examination methods for smell and taste and their clinical value].

The diagnostic of disturbances of the chemical senses is from a clinical standpoint still insufficient, as the literature of the whole world shows. Ten years of experimental and clinical investigations as well as the collection and evaluation of the experiences at the University ENT-Clinic Halle/S., GDR--have helped to develop some new tests and tools like a big and a small smell-case, two electrogustometers, the documentation by means of olfacto- and gustograms and so on. Now in the whole GDR a special group of ENT-scientists, members of our ENT society, are working on standardisation. The experiences will be official in our country. After the representation of our diagnostic system from to-day, as we are using them in our clinic, we are giving clinical examples as the diagnosis of the cranial nerves, the control of the treatment and so on, which are showing the usefulness of such examinations in smell and taste.

Humans↗
PubMedDate not supplied

[New animal experiments on aerobic and anareobic inner ear metabolism].

The inner-ear function is bound up with a permanent oxygen supply. The evidence of it are the patterns of the LDH subunits in inner-ear of eight species. The inner-ear energy turnover of glycolysis post-mortem was demonstrated at those species possessing glycogen storages. The MP2 are alterated by perfusion of glucose or iodoacetic acid. During oxygen respiration the MP are not decreased by iodoacetic acid.

Animals↗