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Biomedical subjects

H Jesserer

Publications and source records attributed to H Jesserer.

13 recordsLinked to original sources

[Differential diagnosis in osteoporosis].

Osteoporosis is a so called metabolic osteopathy. Under this term alterations are included concerning primary the bone tissue, but in consequence disable bone organs. Into this group of affections belong also the osteomalacia, the parathyreogenic osteodystrophy, the osteosclerosis caused by systemic changes of the bone tissue turn-over and furthermore different combinations of such alterations. For their principal diagnosis in every single case the histological findings are most important for their pathogenetic differentiation and for the (therapeutically and diagnostically important) individual specification anamnesis, X-ray findings and several biochemical parameters are important.

Bone Diseases, Metabolic

[Bone scintigraphy in osteodystrophia deformans (Paget's disease)].

The value of combined investigations using both scintiscanning and radiological procedures has been proved for the disease's extension and activity in 28 patients suffering from osteodystrophia deformans (Pagets disease). It was seen that such a method leads to more precise results concerning the patient's condition. Special therapy indications were set up, based on these summarized findings. A further advantage of bones scanning alone is the lower radiation dose, which is mainly indicated for control tests in Paget's course. At present, we have no experience of malignant forms of this disease among our group of patients.

Alkaline Phosphatase

[Principles in the therapy of osteoporosis. 2. Therapy].

"Osteoporosis" is no disease by itself, but solely an anatomically equal result of various etiologic and pathogenetic influences on the bone structure or parts of same. A therapeutic effect and prognosis are dependent on these conditions to a considerable extent. Practically, it is therefore of paramount importance to distinguish between various clinical pictures of osteoporosis as well as to separate them from hypostotic changes of the skeleton. No more than a single type of "osteoporosis" exists, a uniform treatment can be applied. Cause and extent of the change, age and sex of the afflicted, individual complaints and complications determine the therapeutic procedure in every case. Jointly, all efforts tend to stop the decrease of the bone tissue inherent in the porosity, and to achieve, whenever possible, a compensatory increase of the bone structure still remaining by stimulation of the osteopoiesis.

Anabolic Agents

[Principles of the therapy of osteoporosis. 1. Definition, classification, diagnosis].

More and more the treatment of osteoporotic changes of the skeleton becomes a topic of discussion of an emotional nature. Whatever reasons may exist, it can be taken for granted that a considerable interest can be found in the pertinent problems coming up, and that a difference of opinion exist on some issues. However, certain principles should not be disputed, since nowadays there is hardly any doubt as to their validity. To represent these and to compare them with the methods of treatment of an osteoporosis discussed today is the purpose of this information. This first part contains definition, classification and diagnosis.

Adult

[Diagnostic procedure in osteodystrophia deformans Paget].

Simultaneous scintigraphic and X-ray examination has been evaluated in 30 patients with Paget's disease for estimation of extension and activity of the disease. Scintigraphy produces a comprehensive picture of the pathophysiologic condition. When compared with X-rays the procedure is more economic with regards to cost, time and radiation dosage. Therefore, the use of radioisotopes for evaluation of the skeleton is strongly recommended for follow-up examination in Paget's disease.

Alkaline Phosphatase

[Hypercorticism].

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Adrenocortical Hyperfunction

["Side effects" in cortisone therapy].

Glucocorticosteroids are comprehensively acting agents and their therapeutically used derivatives - the cortisonoids - accordingly also have unwanted effects. In addition every pharmacodynamically active medication of these drugs in due time, induces adrenal atrophy and leads to the patient's dependence upon an adequate exogenous supply. This condition is then called "cortisonism". Such a development represents one of the most important risks of cortisone therapy in rheumatic disorders.

Glucocorticoids