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Biomedical subjects

H K Brodie

Publications and source records attributed to H K Brodie.

8 recordsLinked to original sources
PubMed1978

A study of the effects of gonadotropin-releasing hormone on human mood and behavior.

Gonadotropin-releasing hormone in doses up to 500 microgram was administered to 12 healthy male volunteers. Luteinizing hormone and testosterone levels increased subsequent to GnRH administration. No immediate effects of GnRH on mood and behavior were noted, though an increase in alertness, a decrease in anxiety and fatigue, and an increased speed of performance on automatized motor tasks were noted several hours after GnRH administration.

Adult↗
PubMed1977

Biology of psychoses: past research and new frontiers.

This paper reviews major research developments in the biology of mental illness. Theories concerning schizophrenia and affective disease are shown to be based on the mode of action of drugs discovered in the 1950s and used in the treatment of these disorders. Discovery of the endorphins and the development of a new receptor site neurobiology are shown to have a potential major impact on the future of psychiatric research.

Antidepressive Agents↗
PubMed1976

Orgasmic frequency and plasma testosterone levels in normal human males.

Twenty males participated in a 2-month study examining the relationship between 8 a.m. plasma testosterone levels and orgasmic frequency. Within subjects, higher levels of testosterone are associated with periods of sexual activity. Over subjects, however, the direction of the relationship is reversed. Mean testosterone levels were higher for sexually less active individuals.

Adult↗
PubMed1975

A cycle of plasma testosterone in the human male.

The object of the study was to assess the lability of testosterone levels in plasma of normal human males over a long period of time and to search for periodicities in changing levels. Blood samples obtained from 20 healthy young men every second day for 2 months were assayed for total testosterone concentration by radioligand saturation analysis with late-pregnancy plasma. The flucturations of plasma testosterone levels over the total time span were substantial for most individuals; the coefficients of variation ranged from 14 to 42% (median 21%). The presence of periodic functions in these fluctuations was tested by 4 different, relatively independent methods. Close agreement among at least 3 analytic methods was found for 12 out of the 20 subjects. These 12 subjects had cycles of plasma testosterone levels with periods ranging between 8-30 days, with a cluster of periods around 20-22 days. The majority of such cycles were significant at least at the 5% level. The mean amplitudes of these cycles ranged from 9 to 28% of the subjects' mean testosterone levels (average 17%).

Adult↗
PubMedDate not supplied

Negative affect and plasma testosterone: a longitudinal human study.

The association between mood and plasma testosterone was investigated. Every second day for 2 months, a Multiple Affect Adjective Checklist was filled out by 20 young men. Blood samples taken at the same time were analyzed for testosterone concentration. Relationships between hostility, anxiety, and depression and plasma testosterone levels were tested both within and across individuals. Intrasubject correlation coefficients between affects and hormone were fairly evenly distributed between positive and negative values, some significant on either side. Intersubject correlation coefficients were all positivie. Between depression and testosterone, the correlation was significant only at the 10% level; between the other two affects and testosterone, the correlations were not significant.

Adult↗