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Biomedical subjects

H K Chuttani

Publications and source records attributed to H K Chuttani.

At least 37 records · Page 2Linked to original sources
PubMed1973

Chronic liver disease: differences in autoimmune serological reactions between Australians and Asians.

A total of 164 patients from Australia, Ceylon, India, Singapore, and Thailand were studied for the prevalence of autoantibodies associated with "idiopathic" chronic liver disease-namely, antinuclear antibody, smooth muscle antibody, and mitochondrial antibody. The prevalence of these autoantibodies was high among patients from Australia (55%), but was low among patients from Ceylon (14%), India (11%), Singapore (0%), and Thailand (8%). There are variations in types of hepatitis and cirrhosis between races, and this applies particularly to the type associated with autoimmune markers. This may be related to genetic differences that have evolved between peoples of European and Asian descent.

Antibodies, Antinuclear↗
PubMed1971

Pyrantel embonate in treatment of hookworm infestation.

The efficacy of pyrantel embonate (1,4,5,6-tetrahydro-1-methyl-2-(trans-2-(2-thienyl)-vinyl)-pyrimidine embonic acid salt; Combantrin) was evaluated in 60 cases of hookworm infestation. They were divided into six groups of 10 cases. Pyrantel embonate was administered orally, in dosage schedules (randomized) of 100, 75, 50, 20, 15, and 10 mg/kg of body weight. The stool examination for hookworm ova and coproculture were positive in each case. The predominant species was Ancylostoma duodenale (in 58 patients). After treatment with pyrantel embonate the stool examination for hookworm ova and coproculture were negative on the 10th and 15th days in each group. The blood levels of the drug were significantly higher in patients receiving 100 and 75 mg/kg body weight. In groups A and B one patient experienced nausea and vomiting on the day of administration of drug. There were no abnormal changes in liver function tests or blood urea levels in any of the groups. Hence the optimum single dose of the drug effective against hookworm infestation is 10 mg/kg body weight, and further studies are required to evaluate the minimum effective dose of pyrantel embonate.

Administration, Oral↗
PubMed1971

Small bowel in typhoid fever.

Twenty-eight patients with typhoid fever and one patient with paratyphoid fever were subjected to intestinal function tests (faecal fat and D-xylose) and jejunal biopsy soon after recovery from the acute phase of the disease in order to assess the residual functional and morphological status of the small bowel. The results indicate that almost 50% (14/29) initially had defective D-xylose absorption which recovered rapidly. No patient had steatorrhoea. Jejunal biopsies of eight patients out of 22 showed increased chronic cell infiltration; there was, however, no specific lesion. It appears that intestinal injury following salmonellosis results only in mild functional derangement of the bowel which recovers rapidly.

Adolescent↗