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Biomedical subjects

H K Ghosh

Publications and source records attributed to H K Ghosh.

11 recordsLinked to original sources

Comparison of Roche blood culture bottle with an in-house conventional blood culture system.

A comparison was made of the in-use performance of an in-house broth blood culture in a general hospital during 8 mths in 1988 with that of a commercial biphasic culture (BCB system, Roche Products Pty Ltd, Sydney) for the corresponding period in 1989. The clinical services and the number of blood samples tested were comparable. The yields of organisms after 48 hrs incubation were similar in both systems. Staphylococcus aureus showed up 3 times as often after 24 hrs incubation in the conventional system as in the BCB system. Agitation of the BCB facilitated macroscopic detection of growth in the initial 24 hrs incubation.

Bacteriological Techniques

Mebendazole therapy of whipworm infestation: a clinical trial.

Mebendazole, a new broad-spectrum oral anthelmintic for nematodes, was given to patients harboring whipworm in a hospital for the mentally retarded. A three-day regimen (100 mg twice a day) dewormed 75% of the subjects, a five-day regimen cured 95%. The remaining patients excreted strikingly lesser amounts of the parasites' eggs after therapy. No untoward effects were noted clinically. It is the drug of choice in mixed worm infestations.

Adolescent

Odds statistics.

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Clinical Laboratory Techniques

Experience with a simplification of the petroff method for laboratory diagnosis of mycobacteria in sputum.

In the original Petroff procedure sputum is digested with NaOH and the centrifuged deposit neutralized with HCl before culturing. A modification in which digestion is arrested by dilution with water and the sediment is seeded on buffered media is simpler, quicker, safer and in our hands seems to give a greater number of positive smears and cultures for mycobacteria with less overgrowth by contaminants. The usefulness of regular smear examinations for excluding tuberculosis in nonspecific chest complaints is questioned.

Bacteriological Techniques

Terminal exacerbation of chronic melioidosis in New South Wales.

A fatal case of melioidosis, thought to be the third recorded from New South Wales, is presented. Infection probably occurred in Queensland. The patients presented with a subcutaneous abscess complicated by pyaemia, extensive lung involvement and septicaemic shock. The diagnosis was bacteriologically confirmed shortly before death, by isolation of Pseudomonas pseudomallei from blood, pus swabs and tracheal aspirates. There is a need for greater awareness of this disease in persons who have resided in South-East Asia and in North-Eastern Australia.

Adult

Eosinophilic meningitis (angiostrongylosis): a probable case.

A probable case of eosinophilic meningitis is described. This report is thought to be the first of a case of this disorder diagnosed in New South Wales, although infection probably occurred in Queensland. The life cycle of the parasite Angiostrongylus cantonensis is outlined briefly and the clinical manifestations of this disease are discussed. Treatment with thiabendazole seems to have been beneficial to this patient.

Adolescent