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Biomedical subjects

H K Ghuman

Publications and source records attributed to H K Ghuman.

5 recordsLinked to original sources
PubMed1995

Prevalence of hepatitis A, B, C & D in Ludhiana.

172 sera were tested for serological markers of hepatitis A, hepatitis B, hepatitis C and hepatitis D to define the aetiology of acute viral hepatitis by Enzyme immunoassays. The viral aetiology could be decided in 60.5% (104/ 172) of patients. Hepatitis B infection was present in 34.9%, hepatitis A in 10.5%, hepatitis C in 9.3% and hepatitis D in 5.8% of cases. Delta hepatitis associated with HBsAg positive hepatitis was detected in 10% (6/60) of the patients. The aetiology remained undecided in 39.5% of patients.

Acute Disease↗
PubMed1992

Acute delta hepatitis without hepatitis B surface antigen detectable in the blood.

The case is described of a 42-year-old man suffering from acute delta hepatitis without hepatitis B surface antigen (HBsAg) being detectable in his blood. Tests on the patient's blood were negative for anti-HBcIgM and HBeAg but positive for anti-HBs, anti-HBe, HDAg and anti-DIgM. It is well known that the delta antigen-antibody system is detectable only in HBsAg carriers except rarely in persons recently recovered from acute hepatitis B virus (HBV) and delta infection. We report one of the rare cases in which the circulating HBsAg as well as anti-HBcIgM and HBeAg were not found in the patient's serum, thus indicating the absence of recent infection with HBV.

Acute Disease↗
PubMedDate not supplied

Delta-hepatitis.

Investigations were conducted for serological evidence of hepatitis B virus (HBV) and hepatitis D virus (HDV) infections in children suffering from acute viral hepatitis. A total of 52 serum samples were analysed by enzyme immunoassay. Of these, 18 (24%) were positive for hepatitis B virus markers and 34 (65.4%) were negative. Delta virus infection was detected in 6/18 (33%) hepatitis B patients. A significant finding was, that of the 34 patients negative for hepatitis B, 4 (12%) were positive only for HDV although the latter can only occur as a coexistent infection with hepatitis B virus. From the present study it may be inferred that delta virus infection is prevalent in children and absence of HBV markers does not rule out hepatitis D.

Adolescent↗