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Biomedical subjects

H K Toppozada

Publications and source records attributed to H K Toppozada.

16 recordsLinked to original sources
PubMed1983

A hematologic study of pregnant women in free and insurance hospital populations.

The prevalence of anemia among 631 women in late pregnancy was studied among two groups: those in the Medical Insurance Pregnancy Centre of the Alexandria clinic (320) and those in the free government hospitals (311). Some related demographic and social observations were also done. Complete medical and obstetric examinations and several laboratory tests were performed. Women in the insurance hospital had lower parity, smaller families, lower crowding index, better income and a healthier hematological picture than women in the free hospitals.

Adult↗
PubMed1983

Blood hormone levels in egyptian women on norethisterone oenanthate.

Ten Egyptian women who were using the injectable contraceptive norethisterone oenanthate (NET-OEN) for at least 6 months were monitored weekly for a period of 12 weeks by measuring 3 pituitary hormones (FSH, LH and prolactin) and 2 ovarian hormones (oestradiol 17-B and progesterone). It was concluded that NET-OEN is a strong ovulation inhibitor, at least after its use for 6 months. Prolactin levels were depressed and this is in contradiction with the findings in rats.

Adult↗
PubMed1982

A preliminary pharmacological trial of the monthly injectable contraceptive cycloprovera.

A comparative pharmacological pilot study of the monthly injectable contraceptive CycloProvera was carried out in 11 women in four centres. There were no significant differences in the results between the centres except that the injection-bleeding interval appeared to be shorter in Swedish women than in those in Havana and Mexico. Medroxyprogesterone acetate was detectable in blood for 28 to 62 days after injection of CycloProvera and although follicular activity returned in less than 28 days after injection in many of the women, corpus luteum function was suppressed for at least seven weeks in all women. Most of the women retained a regular menstrual pattern; six of 33 cycles were amenorrhoeic. There was no significant change in any of the biochemical and haematological analyses.

Adult↗
PubMed1981

Pharmacokinetics of ethynyloestradiol in women for different populations.

The pharmacokinetics of a dose of 50 microgram ethynyloestradiol administered orally was studied in fourteen centres. Absorption was rapid and the highest serum concentrations of total ethynyloestradiol were found in most subjects at 1 h and by 24 h concentrations were less than 250 pg/ml. Calculation of the half-lives for absorption, distribution and elimination showed wide variations between subjects, the half-life of elimination varying from 2.5 h to more than 30 h. Bioavailability as measured by the area under the serum ethynyloestradiol concentration-time curve also showed more than a ten-fold variation. Intra-centre differences in the various parameters measured were as large as the inter-centre differences.

Biological Availability↗
PubMed1979

Rate of metabolism of norethisterone in women from different populations.

The rate of metabolism of orally administered norethisterone was compared in fourteen centres by measuring plasma levels of the steroid by radioimmunoassay at varying times after oral administration of a 1 mg dose. The inter-centre differences were of the same order as the intra-centre differences. Variations in metabolism appeared not to be due to variations in body size.

Adult↗
PubMed1977

Human tubal fluid collection via vagina and its quantitative variations during the menstrual cycle.

The culdoscope was used for easy approach to the fallopian tube, which was delivered into the vagina, and a Foley catheter (No. 8 French) was introduced through its fimbrial end for collection of human tubal secretion. It was left from one to eight days. The technique was successful in 54 cases out of 60, but we succeeded in collecting enough fluid in 44 cases only. The volume of human tubal fluid was studied in relation to the phase of the cycle. A peak of fluid volume was found to occur at the midcycle.

Body Fluids↗
PubMed1971

Contribution of fetal/maternal incompatibility to aetiology of pre-eclamptic toxaemia.

Data are presented on an association between toxaemia of pregnancy and consanguinity of patients, seen at a Turkish hospital, and their husbands. Women with toxaemia were less frequently related to their husbands than those with no signs of pre-eclampsia. The relationship between toxaemia in twin pregnancies and the sexes of the twin pairs from four sources are examined. In all four pre-eclampsia seems to be more common in unlike-sex than in like-sex twin pregnancies, and, by extension, to be more common in dizygous than in monozygous twin pregnancies.

Chromosome Mapping↗