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Biomedical subjects

H Köhler

Publications and source records attributed to H Köhler.

At least 451 records · Page 25Linked to original sources
PubMed1978

[Analysis of trends in the immunologic supervision of organ transplantation].

Immunological methods of the rejection diagnostics are discussed. The humoral as well as cullular immune response against the graft is taken in consideration. The tests described up to now in literature are not suited or must still be confirmed, respectively. Thus the aptitude of the nucleolar test, of the leucocyte aggregation test, of the MLC-MEM and the rosette inhibition test for the rejection diagnostics should be increasedly examined. The immunological rejection diagnostics is complicated by the immunosuppressive therapy.

Graft Rejection↗
PubMed1978

[Course of cellular immunity in urologic neoplasms].

Apart from a purely qualitative evidence concerning the presence of a specific sensibilisation it is possible to estimate also its strength or the blocking factors appearing in the serum of tumour carriers by means of the electrophoresis mobility test. By this it seems to be possible to make an evidence concerning the immunological reaction position of the tumour patient with the possibility to make conclusions as to the prognosis of the patient.

Antigens, Neoplasm↗
PubMed1978

Immune response to phosphorylcholine. I.V. Comparison of homologous and isologous anti-idiotypic antibody.

Homologous and isologous anti-idiotypic antibodies against the PC-binding BALB/c myeloma protein HOPC-8 were raised in A/He and BALB/c mice, respectively. Isologous and homologous anti-HOPC-8 serum suppressed the response to PC in vitro specifically. The antibodies were purified by using HOPC-8 immunoabsorbent. Purified isologous and homologous anti-idiotypic antibody were labeled with 125I and compared for Ig class composition and idiotype-binding specificity. Both kinds of anti-idiotypic antibodies were predominantly IgG1, were highly specific for the HOPC-8 idiotype, and had a smiliar affinities for the PC-binding site. These findings demonstrate that anti-HOPC-8 antibodies raised in A/He and BALB/c mice are very similar in their biologic and immunochemical poperties.

Animals↗
PubMed1978

[A contribution to the early diagnosis and differential diagnosis of bladder neoplasms by means of immunological methods].

According to the present examinations it is pretty probable that already in early histological forms of the carcinoma of the urinary bladder the EM-test is able to indicate immunologically malignity, i.e. that the papillary non-infiltrating carcinoma of the transitional cell as well as the carcinoma in situ of the urinary bladder (23) also immunologically behave like tumors of the bladder. In differential-diagnostic questions concerning the organ localisation of the primary tumor the EM-test seems to give valuable references. Histologically not unequivocally malignant tumors of the bladder with positive results in the EM-test should be submitted to an exacter examination and control.

Adult↗
PubMed1978

[Sézary syndrome. A case report].

This paper describes a patient who exhibits all signs of Sézary-syndrome. During the 15 years of sickness, the patient has developed a generalised erythrodermia, skin infiltrations, hyperkeratosis on the palms and the foot soles, changes in pigmentation, and generalised swelling of the lymph nodes. Two modifications of Sézary's cells have been found in the peripheral blood and the specific skin infiltrations by both light and electron microscopy. The serum contains large amounts of a macrophage migration inhibitory factor. The illness does not respond to chemotherapy.

Aged↗
PubMed1977

[Demonstration of HBs antigen with the hepanostika test, an enzyme immunoassay (author's transl)].

Sensitivity, specificity and practicability of the Hepanostika test, a newly developed enzyme immunoassay by organon Teknika for the demonstration of HBs-antigen, was compared with results of the Aursria II 125 test. Smallest demonstrable concentration of the antigen in the Hepanostika test eas 3.125 ng/ml with antigens of subgroup ad and 2.08 ng/ml in those of subgroup ay, while it was 1.04 ng/ml for both subgroups with the Austria test. Among 2930 blood donors 85 antigen carriers were discovered by both tests, while with the Hepanostison test, a passive haemagglutination test from Oranon, only nine were discovered. In serial blood samples of patients with various disease there was only a slight difference between the two tests. The Hepanostika test had 1.6--3.88% nonspecific reactions, compared with 0.5-0.8% with the Ausria II 125 test. Both tests thus gave much more specific results than passive haemagglutination. The Hepanostika test is thus a satisfactory alternative to the Ausria test. Because of its high sensitivity it can be recommended for the diagnosis of HBs antigen among blood donors and in clinical laboratories.

Blood Donors↗