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H Kühnle

Publications and source records attributed to H Kühnle.

35 records · Page 2Linked to original sources

[Clinical management of cystic ovarian tumors].

In a prospective study at the University of Göttingen 206 cystic ovarian tumours were examined vaginosonographically. Basing on a graduated schedule, the individual therapy of each ovarian tumour was determined. By use of this clinical management, all blastomas could be detected correctly and in 6.8% of all cases a follicle or corpus luteum cyst was operated per laparotomiam. Basing on the created data, the authors suggest a simple and effective clinical management of cystic ovarian tumours.

Adolescent↗

[Results of clinical trials with the gluconeogenesis inhibitor 2-(3-methylcinnamylhydrazono)-propionate (MCHP)].

Many compounds which directly or indirectly inhibit gluconeogenesis have been described. Some of them showed hypoglycemic action in animal experiments. 2-(3-Methylcinnamylhydrazono)-Propionat (MCHP) a derivative of hydrazine demonstrated marked hypoglycemic action in animal experiments. Nontheless the administration of MCHP to type II diabetic patients showed no hypoglycemic action. Clinical or biochemical sideeffects could not be observed.

Aged↗

[Postoperative therapy of epithelial ovarian cancer at the Göttingen University Gynecologic Clinic. A retrospective analysis of 82 patients 1981-1984].

An epithelial ovarial carcinoma was diagnosed and treated during 1981 to 1984 in 82 patients of the Department of Gynaecology of the University of Göttingen. The diagnostic approach and therapy are described in the paper by Grospietsch et al. [Geburtsh. u. Frauenheilk. 46 (1986), 588]. The present paper deals with the results of postoperative treatment, with particular emphasis on those factors presently considered to be prognostically relevant, such as postoperative tumour residue, age of the patient and stage of tumour spread. The results are classified according to rate of response, progression-free interval and survival time or survival rate. Analysis of the results shows that on the one hand an improvement of long-term results (survival time) has been very unsatisfactory with present-day methods--and moreover, that partly such long-term results are obtained only on the basis of an accurate diagnosis--whereas on the other hand the short-term results (tumour-free interval) together with a clear improvement of the quantity and quality of life do justify the considerable effort required by the treatment concept. Improvement of the overall result is more likely to be achieved by clinical and preclinical research towards consolidation of the primary therapy effect than by employing "trial-and-error" methods within the framework of primary therapy.

Adult↗

[Current aspects of therapy of ovarian cancer. Surgical therapy of epithelial ovarian cancer at the Göttingen University Gynecologic Clinic. A retrospective analysis of 82 patients 1981-1984].

The most important step in the treatment of epithelial ovarian carcinoma is radical surgery which should be as radical as possible, since this can exercise a decisive influence on the effectiveness of subsequent chemotherapy or radiotherapy. During 1981-1984 98 patients with an ovarian carcinoma were operated upon. 82 of these patients had epithelial tumours that will be discussed in the article. The mean age was 59.9 years. 88% of the patients were additionally at risk by one or several risk factors. Surgical approach was standardised: longitudinal incision, hysterectomy, adenectomy, resection of omentum and, if necessary, maximum possible removal of the peritoneum of the pelvis. In 28 cases additional surgery became necessary at the intestine. 77% of the patients (n = 63) were in the advanced stages FIGO III and IV. In 50 patients the operation lasted for up to 4 hours, in 24 up to 6 hours and in 8 for more than 6 hours. Intraoperative complications occurred in 37% (twice lesion of the ureter, in 5 cases intestinal lesion, in 23 cases anaesthesiological problems due to preexisting risks). In stages I and II reduction of tumour size below 2 cm was achieved in 100% of the cases, in stage III in 87.5%, in stage IV in 45%. Two patients died postoperatively. The postoperative complication rate was 48%. Almost 30% of these were represented by cardiopulmonary disturbances. Although the percentage appears high, most of the problems were well manageable, so that the patients could be transferred to follow-up therapy within 2-3 weeks. For type of follow-up therapy, tumour response.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

[Dose calculations for local irradiation of endometrial carcinoma].

A program for a personal computer has been developed to calculate and optimize dose distributions around a high dose intracavitary afterloading applicator having a single source. The problems of the local irradiation of the endometrium-carcinoma are emphasized in connection with the optimization criteria for an adequate irradiation planing. Exemplarily, the anisotropic proportions of absorption around a special type of applicator are calculated. In addition, an algorithm for optimization of dwell times of three-dimensional arranged source positions according to a prescribed dose distribution is theoretically presented. Further, an easy way of finding isodosis by given source positions and dwell times is introduced by taking into consideration the need to superimpose the dose distribution with external radiation fields. All calculations are tested in a water phantom.

Brachytherapy↗

[Cisplatin ototoxicity. A clinical study].

The ototoxicity of cis-DDP (cisplatin) has been known for some time. It affects the outer and inner hair cells of the cochlea which are damaged. So far, the data laid down in the literature concerning extent and frequency of hearing defects differ widely. In the present study we analysed the ototoxic effect of cis-DDP in 124 patients with different types of carcinoma. We investigated a possible dependence of ototoxicity of the patient's age, the platinum dose, the manner of administration, and of the previously existing audiometric anomaly. In 48% of the patients studied we found a therapy-induced, dose-dependent hearing defect mainly at a high frequency range (4-8 kilohertz). Its degree is influenced by the mode of cisplatin application. The most serious hearing defects were caused by a dose of 100 mg per square metre body surface. The results of our investigations are discussed and compared with those of other clinical studies.

Adult↗

[Chemotherapy of advanced ovarian cancer. Göttingen-Hannover studies].

Patients with ovarian carcinoma stages III and IV were treated with cis-platin (P), adriamycin (A) and cyclophosphamide (C). The total rate of remission in group PC (n = 58) was 86% (CR = 55%), in group PA (n = 48) 65% (CR = 48%) and in group PAC (n = 43) 63% (CR 47%). The number of cycles administered were 8 in PA and PAC, and 5 in PC. Half of the patients survived 18 months (PA), 19 months (PAC) and 21 months (PC) without signs of progression with a survival time of 25 months (PA), 27 months (PAC) and 29 months (PC). In patients who had received primary PA therapy, secondary treatment with combined CPC was carried out. Rate of remission 56%. Treosulphan after PC resulted in 14% remissions, etoposid after CP (n = 38) 11 (29%) remissions.

Antineoplastic Combined Chemotherapy Protocols↗

Objective demonstration of cervical softening with a prostaglandin F2 alpha gel during first trimester abortion.

In a prospective study the cervix softening and dilating effects of intracervically applied prostaglandin F2 alpha gel were investigated in 100 patients during induced abortion in the 7-12th week of pregnancy. A specially designed tonometer was used to measure the resistance of the cervical canal before as well as 6-8 h, 4 days and 5-6 weeks after gel application. The cervix of 99 patients proved to be freely passable without use of undue force for at least Hegar 8 after treatment. Measurements in 96 patients 5-6 weeks after the operation showed good general agreement with those values obtained before gel application. No spontaneous or operation-induced lesions of the cervix occurred. Intracervical prostaglandin gel application proved itself to be a safe, practicable and gentle method for avoiding dilation-induced complications during first trimester abortions.

Abortion, Induced↗