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Biomedical subjects

H Künkel

Publications and source records attributed to H Künkel.

36 records · Page 2Linked to original sources
PubMed1984

[The EEG in anesthesia and intensive care monitoring].

Electroencephalographic monitoring during anaesthesia and during intensive therapy has definite advantages. It aids the individual regulation and assessment of general anaesthesiological measures, and signals cerebral insufficiency in the patient under treatment. Examples illustrating initial cerebral states and characteristic changes of cerebral function related to anaesthesia in general, to various forms of anaesthesia as well as to the depth of anaesthesia, are presented. Other examples illustrate the significance of this method in interpreting the actual state of cerebral function during the course of intensive treatment. Possibilities of performing electroencephalographic registration during routine anaesthesiological procedures are discussed.

Anesthesia, General↗
PubMed1979

The significance of personality traits in EEG evaluation of drug effects.

The relatively clear and compact picture of an electroencephalographic classification of psychotropic substances becomes extremely more complex if the influence of personality traits and topographic differentiations in the EEG are taken into account. Using the example of EEG alterations under diazepam, amitriptyline, pyritinol, EMD 21-657 and caffeine, the complex structure of substance effects, personality factors, topographical differentiations, placebo reactivity and spontaneous circadian variability of the EEG is demonstrated.

Amitriptyline↗
PubMed1978

[Annual rhythms in frequency of electroencephalographic patterns (author's transl)].

A series of electroencephalographic features were measured for about 11,500 patients from a clinical population, over a period of five years (1972 to 1976) and were documented using a standarized procedure. It could be shown that for males a definite yearly rhythm was present for the relative frequencies of alpha-type, partial beta-type, and low voltage EEGs, as well as for continuous and grouped dysrhythmias, the amplitudes of which were in the main 20--30% of the average. For females on the other hand, apart from grouped dysrhythmias, no such yearly rhythms could be proven, at the most such with a periodicity of between 14 and 16 months. The data often display trends that are more distinct than the rhythmicity and as such these should be taken into consideration when deciding upon the model used for statistical regression.

Alpha Rhythm↗
PubMed1976

[Multichannel EEG spectral analysis of the caffeine effect].

By means of multichannel Eeg spectral analysis the central effects of caffeine have been investigated during a controlled factorial study with 9 male volunteers. The effects of coffee and caffeine solution with equal concentration, decaffeinated coffee and hot water have been compared on the basis of analysis of variance. The factorial experimental design implemented a randomization concerning the sequence of substances as well as days of week. The principal findings are following: coffee and caffeine solution of equal concentration on the one hand cannot be readily distinguished concerning their Eeg effects, on the other hand the decaffeinated coffee and hot water exhibit very similar Eeg effects. Very marked differences, however, have been found between the two groups of substances. Coffee and caffeine solution both produce a remarkable, highly significant reduction of theta-amplitude, dominant theta-frequency and theta-frequency-variation. The alterations within the alpha range are mainly increase of dominant frequency and decrease of amplitude. These findings may be interpreted as signs of remarkable activation and elevation of vigilance. It should be pointed out that the Eeg effects of caffeine, as well as those of other compounds with central effects, are characterized by topographically different effects. These are not only quantitative, but partially qualitative differences.

Alpha Rhythm↗
PubMed1976

[EEG spectral analysis of caffeine effects].

Spectral EEG analysis is shown to quantify the centrally stimulating effects of caffeine. Comparing the effects of coffee, decaffeinated coffee, caffeine solution and placebo results in two groups of substances: coffee and caffeine solution on one side, decaffeinated coffee and placebo on the other. The within-group differences are negligible, whereas the between-group differences are highly significant. It may be concluded that caffeine is the effective factor. This study gives no valid evidence confirming possible effects of other coffee ingredients.

Adult↗