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Biomedical subjects

H Kelsey

Publications and source records attributed to H Kelsey.

8 recordsLinked to original sources
PubMed1995

Platelet transfusion.

Explore the source record for details and available documents.

Antigens, Human Platelet↗
PubMed1994

Acquired pseudo-pseudo Bernard-Soulier syndrome complicating Gaucher's disease.

AIMS: To investigate the abnormality in platelet function in two patients with type I Gaucher's disease causing a chronic bleeding tendency despite normalisation of the platelet count after spleen removal. METHODS: Routine laboratory methods were used to assess baseline coagulation. Platelet aggregometry was used to assess platelet responses to a range of agonists, and abnormalities were further assessed in mixing experiments using washed platelets and patients' plasma. RESULTS: Platelets from both patients with Gaucher's disease failed to agglutinate to ristocetin, despite normal platelet surface glycoprotein (GP) Ib and plasma von Willebrand factor activity. The agglutination of normal washed platelets was abolished by incubation in patient plasma. The inhibitory activity did not lie in the IgG fraction of patient plasma, and was found to be loosely associated with the patient platelet surface. CONCLUSIONS: The inhibition of ristocetin induced platelet agglutination in patients with Gaucher's disease causes a prolonged skin bleeding time. This could be due to the accumulated glucocerebroside in the plasma coating the platelet membrane. It is suggested that the term pseudo-pseudo Bernard-Soulier syndrome would be appropriate, as on initial screening, the abnormality has the features of Bernard-Soulier syndrome, but further investigation shows normal plasma von Willebrand activity and platelet surface GP Ib concentrations. The inhibitory activity is not due to a platelet specific antibody as is the case in pseudo-Bernard Soulier syndrome.

Adult↗
PubMed1992

Neonatal alloimmune thrombocytopenia due to anti-P1A1 (anti-HPA-1a): importance of paternal and fetal platelet typing for assessment of fetal risk.

Neonatal alloimmune thrombocytopenia (NAIT), which usually involves sensitization to P1A1 (HPA-1a), may have devastating complications for the fetus. These may be prevented by antenatal treatment of severe cases with either maternally administered high-dose gamma-globulin and/or repeated intrauterine platelet transfusions. Determination of the paternal platelet phenotype is useful for counseling parents who have had one or more affected pregnancies. This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.

Adult↗
PubMedDate not supplied

Thrombotic disorders.

The causes and consequences of thrombosis are of interest and concern to a wide range of clinicians and scientists. Accordingly, the Royal College of Physicians joined with the Haemostasis and Thrombosis Task Force of the British Society for Haematology to hold a conference on thrombotic disorders in October 1995. The aim of the conference was to highlight and discuss recent advances in identifying patients at risk of thrombosis and ways of inhibiting the coagulation cascade and platelet function.

Antibodies, Antiphospholipid↗