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Biomedical subjects

H Khurana

Publications and source records attributed to H Khurana.

6 recordsLinked to original sources
PubMed2000

Abuse of neuroleptic drug by psychiatric patients.

Due to the depaminergic neurotrasmission in the mesocortical and mesolimbic reward systems, the neuroleptic drugs have been considered free from the risk of abuse or dependence because of their antidopaminergic properties. Here, two cases of neuroleptic abuse have been described and a possibility of reward circuits other than mesocortical and mesolimbic systems operational behind this phenomenon has been postulated. There is a need to clinically recognise the abuse potential of neuroleptic drugs.

Adult↗
PubMed1999

Huntington's disease and alcohol abuse.

The dopamine, glutamate and GABA systems are known to mediate the effects of alcohol on the movement disorders, though their exact roles are not clear. Thus, use of alcohol has implications for pathogenesis as well as management of the movement disorders. These implications are discussed citing a patient who had a strong family history of Huntington's disease and in whom movement disorder and behavioral problems were manifest under alcohol use and withdrawal, but not while being abstinent.

Adult↗
PubMed1998

Visuospatial and affect recognition deficit in depression.

BACKGROUND: Theorists differ in their opinion whether interpersonal difficulties in depression is associated more with perceptual impairment or with emotional bias. The present study intended to resolve such differences of opinion. METHOD: Major depressives, general medical patients, and non-patient controls were administered three visuospatial and two affective tasks to examine the nature of performance deficit associated with each group. RESULTS: Major depressives were found significantly impaired in both visuospatial and affective tasks in comparison to general medical patients, who in turn, were impaired than non-patient controls. CONCLUSION: Major depressives' perceptual deficit is pervasive and not specific to affective categories. LIMITATION: The study could have been more informative if more psychiatric groups had been included as subjects. CLINICAL RELEVANCE: Improvement in depressives' ability for visuospatial and affective tasks may be considered as a marker of their clinical improvement.

Adult↗