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Biomedical subjects

H Kilani

Publications and source records attributed to H Kilani.

10 recordsLinked to original sources
PubMed2005

Mycophenolic acid plasma trough level: correlation with clinical outcome.

OBJECTIVES: Assess the relationship between clinical diagnosis, state of immunosuppression, mycophenolic acid (MPA) plasma trough levels (MPACmin), and mycophenolate mofetil (MMF) dosage in renal transplant recipients. MATERIALS AND METHODS: MPACmin were determined in 30 kidney transplant patients, of whom 7 exhibited biopsy-proven acute rejection. The remaining 23 had normal graft function. Graft outcome, defined by clinical diagnosis and serum creatinine level, was compared according to MPACmin, MMF dosage, and total lymphocyte count (LC). RESULTS: Patients with acute rejection had similar MPACmin (2.4 +/- 1.7 microg/mL), MMF dosages (1.7 +/- 0.5 g), and LCs (0.001165 +/- 0.0040 x 10(9)/L) when compared with normal patients (2.2 +/- 0.7 microg/mL, 1.7 +/- 0.4 g and 0.001160 +/- 0.00527 x 10(9)/L) respectively. Rejection rates were comparable irrespective of MPACmin)ranges and higher in those receiving the 1-g dose (30%) when compared with those receiving 1.5-g and 2-g doses (12.5% and 11.7%). No relationship was observed between MPACmin and MMF doses, and neither parameter correlated with LC. CONCLUSIONS: These results suggest that MPACmin is a poor correlate of clinical outcome and state of immunosuppression. Although the usually recommended dosage of MMF (2 g) may be associated with acute rejection, low-dose MMF (1 g) seems to constitute a higher risk.

Adult↗
PubMed1987

Effect of head-neck position on elbow flexor muscle torque production.

The purpose of this study was to investigate whether the tonic neck reflex affects elbow flexor muscle torque production in healthy, young adults and which head-neck (H-N) positions have the greatest influence. Forty-eight male and female students between the ages of 18 and 35 years volunteered as subjects. Head-neck positions involving the sagittal and horizontal planes and combinations of these were tested. The nondominant hand was used to apply tension to the lever of an isokinetic analyzer under both isometric (static) and isotonic (dynamic) conditions. Peak torque was determined for each H-N position under each condition. Differences in peak torque were elicited more easily from the female subjects than from the male subjects. Head-neck rotation (horizontal plane) appeared to have a greater influence on elbow flexor muscle torque production than movements in the sagittal plane, particularly when movements in the two planes were combined. We concluded, therefore, that H-N position must be considered during rehabilitation of the upper extremity.

Adolescent↗