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H Kinzel

Publications and source records attributed to H Kinzel.

3 recordsLinked to original sources

Evaluation and optimization of different spectral estimation methods for EEG signals.

The goal of this work was the evaluation of various spectral estimation methods with regard to their suitability for classifying EEG data. A test environment was implemented in which the algorithms are optimized and evaluated using various artificial and real EEG data. The methods are based on autoregressive approaches, as well as from FFT, wavelet, and matching pursuit-based spectral estimations. The evaluation showed that the quality of the results strongly correlate with the computational effort of the algorithm. The matching pursuit algorithm (MP) was implemented and further optimized since it had the best test result and had good scalability. Even under a sufficiently low runtime, it still gave good results.

Algorithms↗

Molecular diagnosis of the Philadelphia chromosome in chronic myelogenous and acute lymphoblastic leukemias by PCR.

We have developed a very rapid method for the detection of the Philadelphia chromosome based on the polymerase chain reaction. This chromosomal translocation generates bcr/abl fusion mRNAs, which were transcribed in cDNAs and subsequently amplified with two sets of primers. Through the use of an additional internal primer set the method reaches the sensitivity to detect a single Ph1-positive cell among 10(5) unaffected cells without any blotting procedures. The whole analytical procedure starting from RNA isolation up to agarose gel electrophoresis can be performed in about 5 h. First results indicate that the frequency of the Ph1 translocation exceeds 40 per cent in certain immunologic subtypes of adult acute leukemia.

Base Sequence↗