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Biomedical subjects

H Knudsen

Publications and source records attributed to H Knudsen.

33 records · Page 2Linked to original sources
PubMed1986

Effect of context on perception of emotion among psychiatric patients.

The purpose of this research was to examine the extent to which verbal statements of context influence psychiatric patients' perception of photographs of emotion (fear, anger, sadness, and happiness). The major findings showed that, when photographs were paired congruently with context statements, there were significant changes in agreement among subjects on two of the four emotion stimuli. There was significantly less agreement on the meaning of facial expressions when the stimuli for fear, anger, and happiness were accompanied by incongruent verbal statements than when they were viewed alone. These data appear to have implications for practitioners working with this population.

Adult↗
PubMed1981

The interlocking treatment system: a model for the delivery of state hospital-CMHC services.

A state hospital began a program in 1975 to integrate the treatment services of the hospital with those of six community mental health centers. The interlocking treatment system that resulted made use of mini-teams of hospital and center staff to recommend referrals to the hospital, develop inpatient treatment programs, and supervise the client's return to the community. The linkages between the hospital and the centers helped ensure continuity of care for clients and to ease their return to community living. A study of hospital wards participating in the system and those not participating showed that participating wards discharged significantly more clients over an 18-month period.

Community Mental Health Services↗
PubMedDate not supplied

Cellular uptake of adamantyl conjugated peptide nucleic acids.

Peptide nucleic acids (PNA) (15-mers) conjugated to adamantyl acetic acid and labeled with fluorescein have been prepared, and their (liposome mediated) uptake in human cells in culture (HeLa, IMR-90 and MDA-MB-453) has been studied by confocal fluorescence microscopy. It is found that adamantyl-PNAs show greatly improved (endosomal) cellular uptake, but that this uptake is dependent on the cell line. Cellular uptake of such lipophilic PNAs is further mediated by cationic liposomes, and in some cases, the intracellular localization is diffuse cytoplasmic or nuclear, again cell-type dependent. The results show that this simple PNA modification can indeed greatly improve cellular uptake, but the effect appears strongly cell-type as well as PNA-sequence dependent.

Adamantane↗
PubMedDate not supplied

Expression of the intercellular adhesion molecule-3 (ICAM-3) in human renal tissue with relation to kidney transplants and various inflammatory diseases.

Adhesion molecules are important for immune regulatory mechanisms concerning antigen presentation, lymphocyte activation, localisation and migration as well as effector-target cell interactions in inflammatory processes. The immunohistochemical expression of ICAM-3, a recently cloned new member of the immunoglobulin family which also binds leucocyte function antigen 1 (LFA-1), was examined in 80 needle core biopsies from 35 renal allografts, 7 patients with mesangioproliferative glomerulonephritis, 5 patients with extracapillary glomerulonephritis, 4 patients with interstitial nephritis and 5 patients with diabetic nephropathy and 20 normal kidneys. In all types of lesions ICAM-3 was constitutively expressed on the majority of infiltrating leucocytes without detectable upregulation or presentation on possible target structures during inflammation indicating its possible role to be mainly in initiation of the inflammatory response.

Antigens, CD↗