Biomedical subjects
Publications and source records attributed to H Koblízková.
A plasmacytic lymphoma of the cervical nodes in a 71-year-old women spread also to the mediastinal nodes and after two years proved fatal. The authors did not detect a rise of monoclonal serum immunoglobulins nor did they detect their presence in the cytoplasm of tumour cells in the nodes subjected to biopsy. The lymphoma was preceded by a specific granulomatous inflammation of the skin and nodes persisting for four years.
A primary pulmonary lymphoma associated with paraproteinemia was observed in a man aged 73. Histologically, the tumour was classed as lymphoplasmocytic lymphoma. No metastases were disclosed at autopsy.
Some mitochondria in leukemic cells in two of nine investigated patients with chronic lymphocytic leukemia and in one patient with morphologically less usual form of this disease contained unusual rodlet-like inclusion bodies. These structures were always present in the matrix of frequently dilatated intercristal spaces. The width of rodlet-like inclusions ranged between 10 and 20 nm, their maximal length was 114 nm. All observed rodlet-like inclusion bodies appeared to be composed of fine filaments 2...3 nm in width and resembled the DNA containing structures in mitochondria of few other cell types. In mitochondria of leukemic cells, however, these inclusions represent a further structural abnormality.
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