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Biomedical subjects

H Kogure

Publications and source records attributed to H Kogure.

10 recordsLinked to original sources
PubMed1989

[A multicenter comparative study in patients with liver metastasis to compare tegafur in new forms with existing drugs. SF-RC.SF-SP Comparative Study Group].

A multicenter comparative study was carried out in 101 patients with liver metastasis to compare tegafur in a new oral form (Sunfural S) and tegafur in a new soft-capsule suppository form (Sunfural Rectal Capsules) with existing drugs. Sunfural S showed a tendency toward high plasma and tissue levels as compared to existing drugs, and clinically, Sunfural S produced survival times that surpassed those of existing drugs. Liver metastasis at the present time has few effective treatments, but we expect that anticancer effects will be obtained through the administration of new drugs with improved bioavailability.

Administration, Oral↗
PubMed1989

[Study on the concentrations of 5-fluorouracil (5-FU), tegafur (ET) and uracil in bile: comparison of UFT or FT].

The serum and bile tegafur (FT), 5-fluorouracil (5-FU) and uracil levels after administration of UFT were assessed in 13 cases of malignant biliary tumor accompanied by biliary obstruction in comparison with FT alone. The serum and bile FT and 5-FU levels showed almost the same transition pattern in both groups, reaching to the plateau in 1-2 weeks and revealing cumulative effect by continual administration. Correlation was obtained between serum and bile levels except for 5-FU level in UFT group (p less than 0.05). Correlation between 5-FU and uracil was obtained in the serum in both groups (p less than 0.05), but no effect of uracil was observed. In bile, correlation was seen only in UFT group (p less than 0.05), and the effect of uracil was observed in bile 5-FU level.

Aged↗
PubMed1979

A case report of leiomyosarcoma originating in the ligamentum teres of the liver.

A case of leiomyosarcoma that appeared to have originated in the ligamentum teres hepatis of a 66-year-old female has been presented. The case was suspected of leiomyosarcoma originating in the ligamentum teres of the liver from the findings by preoperative examinations, and definitely diagnosed as such in a laparotomy and by histological examination of the resected tissue specimen.

Female↗
PubMed1978

[Test production of 60Co sealed sources of high specific activity (author's transl)].

To establish the production technique of 60Co sources with high specific activity, test production was started in 1967 by using JRR-3 and JMTR reactors. Two kinds of cobalt targets, a wafer type (diameter 8.0 mmxthickness 2.3 mm, 1.1g) and a pellet type (diameter 1.0 mmxlength 1.0mm, 6.9 mg) were used. The former was irradiated at a maximum nvt of 4.4x10(20) neutrons per cm2, yielding a maximum specific activity of 8.5 Ci per gram, and the latter at 2.2x10(21) neutrons per cm2, yielding a maximum specific activity of 68.1 Ci per gram, and the total activity of 60Co sources amounted to 4.1 kCi. After the 60Co sources were enclosed in stainless steel capsules, these sealed sources were submitted to wipe and immersion tests to examine surface contamination and leakage. Through the test production, could be obtained much important knowledge such as irradiation method, handling of highly active materials, sources assemblage and remote welding.

Cobalt Radioisotopes↗