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H Kolles

Publications and source records attributed to H Kolles.

29 records · Page 2Linked to original sources
PubMed1992

[Cerebral multisystem atrophy in a patient with depressive hallucinatory syndrome. A case report].

In a female patient, aged 47 years at the beginning, the successive appearance of extrapyramidal signs preceded by depression, paranoid-hallucinatory psychosis, autonomic and cerebellar dysfunction was followed up over a period of 8 years. Autopsy revealed--in accordance with the clinical symptomatology--both olivo-ponto-cerebellar atrophy and a striatonigral degeneration. As a rule these changes are accompanied by dementia. The reported case is unusual in having first presented with severe depression and paranoid-hallucinatory symptoms.

Brain Stem↗
PubMed1991

How to build a computer-assisted, diagnosis-finding system. An example in dermatopathology.

We present a computer-assisted, diagnosis-finding system based on the simple stochastic approach of Bayes; this system was realized in a standard database architecture and run on DOS personal computers. The expert knowledge in the form of specified morphologic criteria was keyed in by means of pull-down menus or downloaded if the system was linked with a reporting system according to the dBASE (Ashton-Tate, Inc, Torrance, Calif) database standard. We present a simple example in dermatopathology but the system shell can also be used for applications in other fields of pathology. This article is not restricted to general remarks about computer-assisted diagnosis finding. The compiled program and the easily comprehensible and well-documented program listings in the CLIPPER (Nantucket Corp, Los Angeles, Calif) or DOS language is available on request.

Diagnosis, Computer-Assisted↗
PubMed1989

[Descriptive epidemiology and prognosis of malignant gynecologic tumors].

Based on data from the Saarland (W. Germany) Cancer Registry, epidemiology and prognosis of gynaecological malignancies is presented for the period 1971-1985. Breast cancer is the most frequent gynaecological tumour followed by tumours of the uterus (cervix + corpus). This is in accordance with worldwide observations. The age distribution of all analysed tumour localisations follows approximately a normal distribution with a maximum between 60 and 65 years of age. Tumours of the breast, cervix and corpus have almost the same prognosis (5-year-survival-rate greater than 60%); the prognosis of ovarian cancer is distinctly poorer. A clear decrease in the incidence is observed only for cervical cancer. The indications are that the proportion of aged patients is continually rising. The mortality, on the other hand, does not increase to the same extent, which indicates a progressive success of therapy of gynaecological malignancies. Since the Saarland Cancer Registry is the only population-based unit functioning for a sufficiently long period, the results represent a model of the situation in the Federal Republic of Germany.

Adolescent↗
PubMedDate not supplied

[Course of illness in malignant primary tumors with skeletal metastases].

About 70,000 malignant primary tumors with skeleton metastases are regarded with respect to tumor age, survival time with metastases respectively with primary tumor and life expectancy. Some cases with mamma carcinoma showed the vertebral type of bone metastasizing whereas the other primary tumors showed the typical type of spreading metastases over the lung. Patients with skeleton metastases are younger than the others. They have a longer survival time than the other patients without bone metastases but they die earlier. In those cases in which the primary tumor was diagnosed because of bone metastases without any earlier tumor treatment the survival time with metastases was longer than in other patients. Metastases with low grade histological differentiation were more often to be seen in patients who got their primary tumor in younger age. These metastases arose in a relatively late stage of the disease.

Bone Neoplasms↗
PubMedDate not supplied

[Life expectancy deficit (LED). A criterion for evaluating the course of malignant tumors. A statistical survey based on 70,231 malignant diseases with special reference to cases with spinal metastases].

The deficiency of life expectancy (DLE), calculated as the difference between the statistical life expectancy at a given age and the survival time with the tumor disease, is a useful measure to extend the concept of tumor malignancy. Both the evaluation of the success of the tumor treatment and the prognosis of the metastatic spread in the vertebral column can be determined with the DLE. For the 9 most frequent tumor localizations the DLE is calculated with the material of the register of cancer in the Saarland/W. Germany (N = 70,128). In an extra part, the DLE for 50 metastases of the spine is compared to the whole cases.

Breast Neoplasms↗
PubMedDate not supplied

An electronic tutorial of neurosurgical pathology--application of multi-media in clinical pathology.

We present an electronic tutorial of neurosurgical pathology developed for standard MS-DOS-computers. No additional software requirements are necessary. Digital pictures are displayed on the computer screen in Super-VGA quality. The user interface allows a dialogue between the pathologist and the engine. The dialogue component consists of scroll bar menus with lists of possible suggestions and answers. For each case the user is supplied with the basic clinical information and a set of representative pictures of the histological specimens. In some cases radiographs and CT-images are available. During the consultation session both routine and special staining methods are available on request. If the user proposes a wrong diagnosis the system offers a commentary. The presented cases are part of a teaching series developed for residents in neuropathology.

Computer-Assisted Instruction↗
PubMedDate not supplied

Characterization of intermediate type (WHO "atypical") meningiomas.

The intermediate type meningioma (formerly "meningioma variant with signs of increased proliferation activity"; WHO "atypical" meningioma) represents a meningioma group the mean Ki-67 index and the recurrence rate of which lie between those of the ordinary and the anaplastic type [Kolles et al. 1995]. In the study cited (n = 160) the percentage of recurrences was 9% in the common, 29% in the intermediate, and 50% in the anaplastic type. The present study focuses on 49 subsequently diagnosed meningiomas of the intermediate type. Apart from certain histopathological features, the most important independent factors associated with recurrence were Ki-67 indices covering the 95% confidence interval between 3.7% and 4.9%. At the light-microscopic level, however, meningiomas in general, and especially those supposed to belong to the intermediate type, are highly variable in tissue architecture and do, in contrast to the anaplastic type, not display frank histological features of anaplasia. Morphologically, the growth pattern of solid ("syncytial") sheets, micronecroses, and large distinct nucleoli are suspicious. Cytogenetically, independent of the loss of one chromosome 22, it has been shown that terminal loss of the short arm of one chromosome 1 (1p-) or complete loss of this chromosome were useful additional indicators of meningioma progression.

Adult↗