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Biomedical subjects

H Koyuncuoğlu

Publications and source records attributed to H Koyuncuoğlu.

48 records · Page 3Linked to original sources
PubMed1977

The antagonizing effect of aspartic acid on the brain levels of monoamines and free amino acids during the development of tolerance to the physical dependence on morphine.

Since it has been shown in previous study that aspartic acid prevents the development of physical dependence on and tolerance to morphine and antagonizes the abstinence syndrom signs, the biochemical bases of that prevention were investigated in the present study. The brain contents of serotonin, DA, NA, and free amino acids of the rats given aspartic acid and morphine separately and in combination were determined. It has been observed that most of the morphine-induced changes in the brain were normalized in the group given aspartic acid and morphine together. The relative ineffectiveness of aspartic acid in normalizing some amino acid levels decreased by morphine was discussed and some logical explanations were found.

Amines↗
PubMed1975

The effects of DL-p-chlorophenylalanine and DL-alpha-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat.

The changes in the brain levels of catecholamines, serotonin and free amino acids have been considered as a factor in the development of the physical dependence on and tolerance to some drugs. In order to show the relationships among the brain levels of these substances, three groups of rats were given i.p. DL-alphaMpT alone, DL-pCPA alone, or DL-alphaMpT and DL-pCPA together, twice a day for three days. Another group was kept as control. The brain levels of catecholamines, serotonin and free amino acids were determined. Although DL-alphaMpT and DL-pCPA alone caused a decrease in the levels of catecholamines and serotonin respectively, the administration of DL-alphaMpT and DL-pCPA together did not. The changes in the levels of free amino acids which were found were related to the metabolism of catecholamines and serotonin.

Amino Acids↗
PubMedDate not supplied

Comparison of the development of experimental pyelonephritis in homozygous brattleboro diabetes insipidus rats, heterozygous control rats and normal Wistar rats.

A comparative study was performed on haematogenous experimental pyelonephritis by injecting a Staphylococcus aureus suspension i.v. to homozygous and heterozygous Brattleboro and Wistar rats. The numbers of viable bacteria in blood, urine and kidney homogenates and the pathomorphological scores determined on the tenth day of infection were significantly lower in Brattleboro diabetes insipidus rats than in heterozygous Brattleboro and normal Wistar rats. The results suggest that homozygous Brattleboro rats are much more resistant to experimental pyelonephritis.

Animals↗
PubMedDate not supplied

The effect of aspartic acid on the intensity of physical dependence in morphine dependent mice.

The mice (Balb/C strain) given 2% aspartic acid in 5% saccharose solution or only saccharose solution (p. os) starting 12 hr before the sc morphine pellet implantation until the removal of pellet were rendered physically morphine dependent. During the development of morphine dependence and after the removal of pellets (on 3-d day) spontaneous motor activity and analgesic threshold were measured as reliable abrupt withdrawal signs. Aspartic acid prevented to some extent the appearance of symptoms of physical morphine dependence.

Analgesia↗
PubMedDate not supplied

The treatment with L-aspartic acid of persons addicted to opiates.

Two clients addicted to codeine, two to heroin and four to opium tincture were orally administered 2 g L-aspartic acid four times daily for up to five days on an out-patient basis. The clients were withdrawn from the drugs on which they were physically dependent by gradually decreasing the amount of the drug abused. Some mild abstinence signs and symptoms were observed during the treatment, while the clients showed a marked improvement in social contacts and behaviour. At the end of the treatment period, and during the subsequent two weeks, not one of the treated persons showed any sign of the abstinence syndrome or expressed a feeling of need for the compulsive intake of the drug which had been abused.

Adult↗