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Biomedical subjects

H Krim

Publications and source records attributed to H Krim.

2 recordsLinked to original sources

Temporal and spatial analysis of potential maps via multiresolution decompositions.

Cardiac potentials recorded on the epicardium or the body surface by an array of electrodes are usually analyzed either as spatial distributions or temporal waveforms. Thus, the analysis often involves temporal descriptors (eg. max dV/dt) or spatial descriptors (eg. location of local extrema) only. The best known transform technique that has been applied to these data that combines both spatial and temporal characteristics is the Karhunen-Loeve transform, a global transform applied to temporal and/or spatial bases obtained by statistical analysis of a database. As an alternative, multiresolution decompositions and related wavelet-type transforms have recently seen great development in signal processing and related fields. They offer flexibility, employing transformations onto local (rather than global) and fixed (rather than data-dependent) databases, and allow transformation of distributions, waveforms, or both, as desired. The utility of this method as applied to temporal and spatial segmentation and analysis of map data from both epicardial plaques and body surface potentials recorded during percutaneous transluminal coronary angioplasty is illustrated.

Body Surface Potential Mapping↗

Analysis of PTCA-induced ischemia using an ECG inverse solution or the wavelet transform.

In patients without significant collaterals, percutaneous transluminal coronary angioplasty (PTCA) produces acute transient ischemia that is detectable in both standard electrocardiograms (ECG) and body surface potential maps (BSPMs). Control recordings made before or between inflations provide personalized baselines, which isolate the effects of ischemia from interpatient differences, such as torso shape and electrode location. In this study, two methods of evaluating PTCA-induced ischemia from BSPM recordings are presented. In the first method, an ECG inverse solution that estimates epicardial potentials from body surface signals using a realistic model of torso geometry is applied. The strength of this method lies in its potential ability to localize areas of cardiac ischemia on the epicardial surface. In the second approach, wavelet transforms were used to perform a multiresolution decomposition of the BSPM data into different frequency bands. The basis functions of the wavelet transform are time-limited and narrow band and hence can be expected to be sensitive to features of the BSPM that originate in discrete electrophysiologic events, such as intrusion of the activation front onto regions of ischemia or arrhythmias due to local conduction abnormalities. The method also offers a means of temporal and frequency localization of cardiac events related to the initiation of injury currents and abnormal conduction due to PTCA-induced ischemia. The inverse solution and the wavelet transform each offer new views of the spatial and temporal courses of acute ischemia potentially leading to new diagnostic insights in ECG patient examination.

Angioplasty, Balloon, Coronary↗