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Biomedical subjects

H Krous

Publications and source records attributed to H Krous.

12 recordsLinked to original sources
PubMed1999

Suffocation, shaking or sudden infant death syndrome: can we tell the difference?

Given that the diagnosis of sudden infant death syndrome (SIDS) remains one of exclusion, problems still exist in distinguishing possible cases from those where the deaths were due to accidental or inflicted suffocation. The term 'SIDS' cannot be used unless a complete autopsy examination has been performed, augmented by review of the clinical history and examination of the death scene. In the absence of a cause of death, a more suitable designation in the presence of inflicted injury is 'undetermined' rather than 'SIDS'. Use of standard autopsy and death scene protocols that have been endorsed by professional bodies will improve the investigation of unexpected infant death and will increase the likelihood of diagnosing subtle disorders that may be confused with SIDS.

Asphyxia↗
PubMed1998

Suprasellar germinoma associated with Cushing's disease and diabetes insipidus in a child.

Cushing's disease is described in a child with a suprasellar germinoma. The patient presented with all of the classic stigmata of Cushing's disease as well as diabetes insipidus, but after surgical resection of the lesion was found to have pathology incompatible with an ACTH-secreting tumor. We believe that this is the first reported incidence of Cushing's disease associated with a suprasellar germinoma. The implications of this unusual association are discussed.

Adolescent↗
PubMed1995

Fibrous hamartoma of infancy: a report of two cases in the genital region.

OBJECTIVES: Fibrous hamartoma of infancy (FHI) is an uncommon subcutaneous proliferative lesion usually found in the upper portions of the body, particularly in males during the first 2 years of life. We report 2 cases of FHI in the genital region. METHODS: We retrospectively reviewed the charts of children treated at Children's Hospital and Health Center, with FHI located in the genital region. RESULTS: We report 2 cases of FHI in the genital region, 1 involving the scrotum and 1 the labium majus. CONCLUSIONS: FHI should be considered in the differential diagnosis of genital masses in children. The histologic features are characteristic, local excision of the tumor is curative, and the local recurrence rate is low.

Child↗
PubMed1994

Distal spinal cord pathology in the VATER association.

Herein the authors report the pathology of six cases of VATER association and tethered spinal cord that underwent operative intervention for removal of lipomas of the conusfilum terminale and/or release of the tethered cord. In five of the six patients, the excised filum terminale consistently showed excessive mature adipose tissue, normal blood vessels, small myelinated nerve fibers, and fibrous connective tissue. One patient had mature lobulated adipose tissue and vessels only. It is concluded that patients with the VATER association who present with distal spinal cord pathology consistently have abnormal involution of the filum terminale, the hallmark being an abnormal collection of mature fat, thickening of the filum, and extension of the fat into the conus medullaris.

Abnormalities, Multiple↗
PubMed1984

Enhancement of gentamicin nephrotoxicity by magnesium depletion in the rat.

This study examined the possible enhancement of gentamicin-induced nephrotoxicity by coexisting magnesium depletion. The effect of concurrent magnesium depletion on enhancing gentamicin-induced nephrotoxicity was measured by azotemia and mortality contrasted to magnesium repleted control rats also receiving gentamicin. After 28 days of dietary preparation, magnesium depleted rats and their magnesium repleted controls were each subdivided into 3 groups: (1) saline injection (NS); (2) gentamicin 80 mg/kg/day, and (3) gentamicin 120 mg/kg/day. Injections were continued for 14 days. All rats receiving gentamicin had proteinuria, increased mortality and significant renal morphological abnormalities. However, those rats which were concurrently magnesium depleted had statistically significant increments in BUN levels, more apparent renal tubular damage, and earlier mortality than the magnesium repleted controls. These observations support the view that concurrent magnesium deficiency in the rat enhanced gentamicin nephrotoxicity.

Acute Kidney Injury↗
PubMed1977

Myocardial mitochondrial calcifiction in Reye's syndrome.

Ultrastructural and biochemical studies of myocardial tissue from a patient with the clinical and light microscopic features of Reye's syndrome showed evidence of intramitochondrial calcium deposition. The significance to recent experimental and clinical data concerning intramitochondrial calcium deposition.

Adolescent↗