Biomedical subjects

H Krsnjavi

Publications and source records attributed to H Krsnjavi.

6 recordsLinked to original sources

PubMed1992

Environmental effects on chromosomes in oncology and radiology department personnel.

Long-term, low levels of antineoplastic drugs and ionizing radiation in the work environment may have genotoxic effects on chromosomes in personnel. The effects of ionizing radiation is acknowledged in occupational medicine and therefore various measures have been undertaken to prevent such effects. However, there are no protective measures for workers exposed to antineoplastic drugs. In this study metaphase chromosome preparations were analyzed in 126 nurses and radiology technicians. They were divided into three equal groups. The first group consisted of shift nurses in an oncology department handling antineoplastic drugs. The second group consisted of radiology technicians in a radiology department and the third group acted as controls. Structural chromosomal aberrations were increased among those nurses exposed to antineoplastic drugs in comparison with technicians (P less than 0.05) and controls (P less than 0.01), respectively.

Adult↗

PubMed1992

[Serum selenium level as a diagnostic parameter in breast cancer].

The level of selenium in blood serum was determined in 33 patients with breast cancer, 13 women with verified mastopathy, and 43 healthy subjects from the Zagreb area. In the second and third quartiles the values of selenium obtained from sick subjects (41-58 micrograms/l) and healthy subjects (73-89 micrograms/l) differed significantly (p less than 0.001). In the group of subjects with mastopathy, serum selenium in the same way ranged from 67-70 micrograms/l and did not differ significantly from the group of healthy women, but differed significantly from the patients with breast cancer (p less than 0.001). Such a result leads to the conclusion that determination of selenium in the blood could be used as a noninvasive diagnostic parameter in clinical assessment of malignant breast disease.

Adenocarcinoma↗

PubMed1991

Acute intermittent porphyria and hormone disbalance.

A study of acute intermittent porphyria (AIP) in three female patients indicates the necessity of stressing that in cases of clinical and laboratory exacerbation of the disease in patients of reproductive age the possibility of the existence of pathological changes in the ovaries (polycystic ovary, anovulatory cycle) should be taken into consideration. By examination of patients' endocrinological status and on the basis of the experience of clinicians it can be concluded that in such cases of exacerbation of the disease, apart from conventional therapy with glucose, Panhematin, electrolyte correction and other symptomatic therapy, coexisting steroid deficiency should be corrected.

Adult↗

PubMed1991

[Urinary incontinence in female workers in the area of Zagreb].

To determine the incidence of urinary incontinence among female workers 383 women with different jobs from three firms were examined over a three-year period. Examination comprised a systematic gynaecological check-up and a questionnaire. The established incidence was 4.7%. Among the factors known to predispose damage to the pelvic muscles the number of births, physical work and body weight failed to show the expected impact, whereas age was highly significant in respect to the symptoms of incontinence (P less than 0.001). The age-related degeneration and involution of the genital tract can be cured if treatment is started early enough. Regression of symptoms was noticed in 66% of the treated women.

Adult↗

PubMed1990

Selenium in serum as a possible parameter for assessment of breast disease.

The level of selenium in blood serum was determined in 33 patients with breast cancer, 13 women with verified mastopathy, and 43 healthy subjects from the Zagreb area. In the second and third quartiles the values of selenium obtained from sick subjects (41-58 micrograms/L) and healthy subjects (73-89 micrograms/L) differed significantly (P less than 0.001). In the group of subjects with mastopathy, serum selenium in the same way ranged from 67-76 micrograms/L and did not differ significantly from the group of healthy women, but differed significantly from the patients with breast cancer (P less than 0.001). Such a result leads to the conclusion that determination of selenium in the blood could be used as a non-invasive diagnostic parameter in clinical assessment of malignant breast disease.

Adenocarcinoma↗

PubMedDate not supplied

A contribution to the world selenium map.

Atomic absorption spectrophotometric method was used to determine the serum selenium levels of 86 healthy individuals. Variations in age, sex, and geographically different urban regions of Yugoslavia were investigated. A group of 63 healthy children, ages 8-15 yr, were examined. Mean +/- standard deviation of the serum selenium concentration was 57 +/- 9 micrograms/L; age and geographic area had no effect on the Se status of children, but the difference between boys and girls was significant (P less than 0.05). A group of 23 men from Zagreb, ages 22-37 yr, were examined. The group was divided into three age subgroups and no difference was found among these groups. The mean Se concentration was 69 +/- 18 micrograms/L, and a statistically significant difference was found only between the group of adults and the group of children (P less than 0.05).

Adolescent↗