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Biomedical subjects

H Kudish

Publications and source records attributed to H Kudish.

5 recordsLinked to original sources
PubMed1986

In vitro secretion of deoxycorticosterone by a benign Leydig cell tumor of the testis.

We evaluated the in vitro steroidogenic potential of a benign Leydig cell tumor of the testis. Tumor tissue was found to secrete deoxycorticosterone, progesterone, 17 alpha-hydroxyprogesterone, estradiol and testosterone into the medium. No corticosterone or aldosterone was detected. The ratio of progesterone to 17 alpha-hydroxyprogesterone was 4:1, consistent with a partial enzymatic block of 17 alpha-hydroxylase. The finding of deoxycorticosterone indicates the presence of 21-hydroxylase activity within the tumor. The high local levels of estrogen produced by Leydig cell tumors may induce this enzyme system and, together with the elevated concentrations of progesterone serving as substrate, may provide a favorable hormonal milieu for extra-adrenal deoxycorticosterone production by these neoplasms.

Adult↗
PubMed1982

Hemodynamic changes during prostatectomy in cardiac patients.

Hemodynamic responses to transurethral prostatectomy (TURP) were studied in 9 patients with severe cardiac disease. This group of patients tolerated spinal anesthesia and TURP in an unpredictable manner. One adverse effect was the high pulmonary capillary wedge pressures (WP of 21 mm Hg or higher) in 4 of the 9 patients during operation. All nine cases were considered. Attention was directed toward significant cases. The high WP was not always indicated by high CVP either before or during operation, and it did not necessarily relate to the amount of fluid utilized or amount of prostate resected. Another adverse effect was the marked changes in systemic resistance in 6 patients. Because of the unpredictable hemodynamic responses, thermodilution flow-directed pulmonary artery catheter was valuable in several cases. It made it possible to select specific therapeutic agents and direct tham at isolated hemodynamic dysfunctions.

Aged↗
PubMed1981

Benign macro-orchidism in a pubescent boy.

We report on a 12 1/2-year-old boy with bilateral testicular enlargement. After an extensive evaluation we eliminated precocious puberty, hypothyroidism, congenital adrenal hyperplasia, X-linked mental retardation and bilateral malignant testicular neoplasms from consideration. Diagnosis was benign macro-orchidism. The clinical and laboratory features of this condition are sufficiently distinct from the other causes of testicular enlargement to allow a diagnosis to be made without testicular biopsy or orchiectomy.

Child↗