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Biomedical subjects

H Kurome

Publications and source records attributed to H Kurome.

9 recordsLinked to original sources

Ocular findings in Japanese women with nevus of Ota.

BACKGROUND: Nevus of Ota is common in Japanese women, but most patients are not examined ophthalmologically. METHODS: We performed ophthalmologic examinations on 16 Japanese women who had had bluish pigmentation in the periorbital region, sclera, and conjunctiva since birth. RESULTS: Fifteen patients had unilateral involvement, and one had bilateral lesions. The visual acuities were good, and the intraocular pressures were within normal range. All patients had a negative family history. Three patients had light pigmentation in the optic disc in the affected eye. CONCLUSION: We believe that optic disc pigmentation associated with nevus of Ota, as found in these three patients, may be common but have been rarely described.

Adolescent

Retinopathy and subconjunctival haemorrhage in patients with chronic viral hepatitis receiving interferon alfa.

A total of 43 patients (86 eyes) with chronic viral hepatitis were examined prospectively before and after the start of interferon therapy. Of 37 non-diabetic patients, 23 (group A1) did not have retinopathy or subconjunctival haemorrhage, 11 (group A2) developed retinopathy, and three (group A3) exhibited subconjunctival haemorrhage during the treatment. In most eyes, the retinopathy disappeared after therapy was stopped. Of six diabetic patients, three (group B1) developed retinopathy and three (group B2) showed progression of existing retinopathy. Thrombocytopenia was not associated with the retinopathy in any patient. The patients' good visual acuity remained unchanged, even after retinal changes appeared. Ophthalmologists should be aware that retinopathy and subconjunctival haemorrhage may develop in patients with chronic viral hepatitis receiving interferon therapy.

Adult

Bilateral microphthalmos with poor visual acuity, high hyperopia, and papillomacular retinal folds in siblings.

Ophthalmological examinations were carried out on a 4-year old girl and her 2-year-old brother who have had poor visual acuity since birth. A consanguineous relationship was found between the parents. Both children had bilateral microphthalmos, poor visual acuity, high hyperopia, and papillomacular retinal folds. No ocular coloboma or systemic abnormality was found. We believe that the ophthalmic findings in these patients are rare.

Child, Preschool

HLA antigens in a Japanese family with Behçet's disease.

BACKGROUND: Familial Behçet's disease is rare. METHODS: HLA antigens in a Japanese family with Behçet's disease were examined. RESULTS: The affected patients had HLA B51, and unaffected family members also had the same antigen. CONCLUSION: It is likely that not only HLA B51 but also other factors may be involved in the pathogenesis of Behçet's disease in Japanese patients.

Adult

Bilateral congenital grouped pigmentation of the retina in a patient with left superior rectus muscle palsy.

A 39-year-old man with left superior rectus muscle palsy had many sharply circumscribed, variable-sized pigmented spots in both fundi. His visual acuity, visual fields, and color vision appeared normal bilaterally. The electroretinographic responses were also normal. His family members were unaffected by pigmented spots in the retina. We believe that the bilateral congenital grouped pigmentation of the retina found in our patient may be rare.

Adult

Initial rapid decrease in visual acuity in siblings with Stargardt's disease.

Two siblings with Stargardt's disease who had an initial rapid decrease in visual acuity were reported. The 8-year-old boy and his 5-year-old sister experienced a bilateral visual decrease within a period of 3 months. Their parents had a consanguineous relationship. Macular changes and blocked choroidal fluorescence were noted bilaterally in both children. Normal color vision, normal or subnormal electroretinographic findings, and subnormal electro-oculographic responses were found. Stargardt's disease should be included in the list of conditions showing rapid decrease in visual acuity.

Child

A Japanese family with Grayson-Wilbrandt variant of Reis-Bücklers' corneal dystrophy.

A 50-year-old man (the proband) experienced recurring attacks of ocular irritation and had had bilateral ring-shaped anterior corneal opacity since adolescence. Corneal sensation was normal. The proband's 15-year-old daughter also had recurring episodes of ocular irritation and bilateral fleck-like anterior corneal opacities. The proband's deceased father and brother reportedly had similar corneal lesions from adolescence. We believe that the corneal findings in this family may be similar to those found in patients with the Grayson-Wilbrandt variant of Reis-Bücklers' corneal dystrophy.

Adolescent

Viscoelastic substance in the anterior chamber elevates intraocular pressure.

An 85-year-old man underwent an extracapsular cataract extraction OD with posterior chamber intraocular lens implantation. Sodium hyaluronate (0.3 mL) was used during the procedure, and approximately 1.0 mL of the solution, including the sodium hyaluronate, was aspirated before wound closure. The next day, the intraocular pressure OD was elevated to 60 mmHg, and it remained high despite medication. Three days later, the intraocular pressure was still high, a paracentesis was done, and viscous solution was obtained. After the paracentesis, the intraocular pressure OD normalized.

Aged