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Biomedical subjects

H Kuwata

Publications and source records attributed to H Kuwata.

54 records · Page 3Linked to original sources
PubMed1989

A case of hemangioendothelioma of the small intestine.

An 81-year-old female was admitted to hospital with anemia and abdominal discomfort, however, various pre-operative diagnostic work-ups for the gastro-intestinal tract revealed no significant change. At the time of surgery, a small intestinal tumor was discovered by means of endoscopy and seven centimeters of ileum was radically resected. The tumor was subsequently diagnosed histopathologically as hemangioendothelioma. The patient recovered quickly and now, 6 years later, has had no sign of tumor recurrence. The incidence of this tumor is reportedly less than 3 per cent of all tumors found in the small intestine and the prognosis of this tumor in the small intestine is poor. A five-year-survival rate can be referred to only 33.3 per cent of the reported cases.

Aged↗
PubMed1988

Mucus glycoprotein and mucosal protection.

For assessing the participation of mucus glycoproteins in the cytoprotective process, mucus glycoprotein content in the rat gastric mucosa was measured after treatment with 70% ethanol with or without prostaglandin (PG) E derivatives or 20% ethanol pretreatment. Oral administration of two synthetic PGE derivatives did not cause any significant changes in mucus glycoprotein content. Seventy percent ethanol administration caused marked reduction in mucus glycoprotein content (about 50% of control) as well as severe gastric mucosal damage. Treatment with two PGE derivatives (10-100 micrograms/kg) prior to 70% ethanol administration markedly inhibited the gross mucosal lesion, whereas the glycoprotein content under these conditions was significantly less than that in the untreated control group (ranging from 67-88% of control). Pretreatment with 20% ethanol markedly inhibited the gross mucosal damage caused by 70% ethanol dosing but the inhibition in the reduction of mucus glycoprotein content was restricted to about 80% of the untreated controls. In summary, cytoprotection induced by PG was not accompanied by entire conservation of intramucosal mucus glycoprotein in the gastric mucosa.

Alprostadil↗
PubMed1988

Changes of rat gastric mucus glycoproteins in cytoprotection: influences of prostaglandin derivatives.

The effects of two synthetic prostaglandin E derivatives on mucus glycoproteins in the stomachs of rats were evaluated. Neither derivative caused change in mucus glycoprotein content in the gastric corpus or antrum, but both increased the biosynthetic activity of mucus glycoproteins in these regions (about 15-30%). Furthermore, the effects of the pretreatment of these derivatives on conserving mucus glycoproteins in ethanol-induced gastric lesions were examined. Treatment with these derivatives 60 min prior to 70% ethanol administration markedly inhibits the decrease in gastric mucus glycoprotein content caused by 70% ethanol. But the glycoprotein content under these pretreatment conditions was significantly less (12-19%) than that in the control group without any drug treatment.

Alprostadil↗
PubMed1985

A staphylococcal coagglutination test for detecting and serogrouping Legionella pneumophila.

For detection of Legionella pneumophila and determination of its serogroup, the modified staphylococcal coagglutination test was studied in detail. Cross-reactions in serum-agglutination tests were observed among serogroups, but immunoglobulin-coated staphylococcal cells could detect L. pneumophila with high sensitivity (a cell concentration with an absorbance of 0.008 at 660 nm could be detected) and serogroups could be determined without cross-reactions. Moreover the coexistence of other bacteria did not affect the results of the test. These results suggest that the staphylococcal coagglutination test is useful for detection and identification of Legionella, especially in environmental samples, and for serogrouping of isolates of L. pneumophila from clinical specimens.

Agglutination Tests↗
PubMed1982

[Effect of acetyllactoylcholine-1,5-naphthalene disulfonate on the motility of stomach].

The effect of TM-723 on the motility of stomach was investigated by using the electromyogram, extraluminal strain gauge force transducer in dog and by measuring the human gastric emptying time. Three mongrel dogs were equipped with two bipolar electrodes on the serosal surface of the antrum and single bipolar electrode and single strain gauge on the surface of the body. Both the peristaltic spike discharge and contractile activity were recorded during 30 minutes before and 60 minutes after administration of TM-723 1 mg/kg, 3 mg/kg and 5 mg/kg, iv. The peristaltic spikes were suddenly disappeared on administration of TM-723 and after then, recurrent peristaltic spikes were recognized with prolonged interval and increased propagation velocity for about four minutes. The contractile activity increased with the administration of TM-723 for a minute. Gastric emptying time were measured on four healthy men by using of the test meal containing 300 muCi of 99mTc-DTPA before and after administration of TM-723 50 mg per os. The following results were obtained that three of four men had accelerated emptying time and one had no remarkable changes after taking TM-723. These studies suggest that TM-723 activates the motility of the stomach.

Acetylcholine↗
PubMedDate not supplied

Effects of omeprazole on rat gastric mucus glycoproteins with acetylsalicylic acid-induced gastric damage.

Investigations were carried out to determine the effects of omeprazole on mucus glycoprotein in rat gastric mucosa. Quantitative and qualitative changes in mucus glycoprotein, isolated from omeprazole-treated rats with or without acetylsalicylic acid-induced gastric damage, and the degree of gastric mucosal injury were studied. Omeprazole, in a dose-dependent manner, prevented macroscopical mucosal damage induced by acidified acetylsalicylic acid. A considerable decrease in corpus mucus glycoprotein (54%) and antral mucus glycoprotein (72%) was observed in acetylsalicylic acid-treated rats and acetylsalicylic acid reduced the amounts of fucose and galactose of corpus mucus glycoprotein. Pretreatment with omeprazole partially restored a quantitative reduction and a qualitative change of carbohydrate portion in corpus mucus glycoprotein induced by acetylsalicylic acid. A single administration of a high dose of omeprazole (200 mumol/kg) also induced the reduction of corpus mucus glycoprotein content (82%), although no changes in the carbohydrate component were observed. The decrease in corpus mucus glycoproteins induced by omeprazole might be due to a cause different from that of acetylsalicylic acid-induced mucus glycoprotein reduction.

Animals↗