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Biomedical subjects

H L Anderson

Publications and source records attributed to H L Anderson.

At least 37 records · Page 2Linked to original sources
PubMed1992

Extracellular fluid and total body water changes in neonates undergoing extracorporeal membrane oxygenation.

After being placed on extracorporeal life support (ECLS), newborn patients typically weight 5% to 30% more than their birthweight. Recovery and eventual decannulation from ECLS is associated with a return to baseline weight or birthweight values after a pronounced diuresis. It has been assumed that the increases in weight in these patients are due to increases in extracellular fluid (ECF) and total body water (TBW). This study was undertaken to prove or disprove this hypothesis. ECF space was measured using the compound sodium bromide and TBW was determined with the use of deuterium oxide (nonradioactive heavy water). Fluid compartment measurements were made prior to the institution of ECLS, immediately after placement on bypass, approximately every other day while on bypass, and a final measurement was made once the patient was off bypass. Sodium bromide concentration was analyzed by high-pressure liquid chromatography, and deuterium oxide concentration was measured by the falling drop method. Eight newborns with respiratory failure were placed on either venoarterial (4 patients) or venovenous (4 patients) ECLS for an average of 106 hours (range, 71 to 219 hours). Pre-ECLS TBW was high in the neonates (87% of total body weight v the normal of 75% to 80%). Mean values for each fluid compartment were corrected for the additional volume of the bypass circuit when the patient was on bypass. ECF increased immediately after the institution of ECLS; however, both ECF and TBW decreased during the bypass run, and post-ECLS levels of ECF and TBW were similar to those found prior to ECLS.(ABSTRACT TRUNCATED AT 250 WORDS)

Body Water↗
PubMed1992

Holistic attitudes of high school students toward themselves and their school experiences.

This study was based on an analysis of essays written by 47 teacher education students in response to the question, "If you could live your high school days over again, what, if anything, would you change?" The responses were organized into 20 different categories and tabulated according to students' age and sex. In retrospect, 38% of these students would have improved their attitude toward high school. Thirty-six percent indicated that high school was a positive experience, though this attitude was often unrelated to academic achievement. The responses strongly suggest that for many high school students, general attitude toward school affects achievement more than do attitudes toward specific school characteristics.

Adult↗
PubMed1991

Elective tracheotomy for mechanical ventilation by the percutaneous technique.

Percutaneous dilatational tracheotomy is a safe, efficient procedure for elective tracheostomy placement. It is not a technique for emergency tracheotomy. It should be performed only by surgeons experienced in conventional tracheotomy. The advantages of placement at the bedside, speed, and relative inexpense make it attractive in the care of critically ill patients.

Humans↗
PubMed1990

Extracorporeal membrane oxygenation for pediatric cardiopulmonary failure.

Extracorporeal membrane oxygenation is now standard treatment of severe respiratory failure in newborn infants in our center (200 cases) and worldwide (over 2500 cases), but there are few reports of such trials in older children. We reviewed our experience with extracorporeal membrane oxygenation in 33 children aged 1 week to 18 years between 1971 and 1989. The modality was used when all other treatment failed. Extracorporeal membrane oxygenation provided excellent cardiopulmonary support for 1 to 25 days (average 7 1/2 days). The survival rate was 25% for cardiac support patients and 47% for respiratory failure patients (36% overall survival). Mechanical complications included membrane lung failure, tubing rupture, and pump failure, all managed without mortality. Physiologic complications included bleeding, pneumothorax, cardiac arrest, renal failure, hepatic failure, and brain injury. The major cause of death was irreversible injury to lung, heart, or brain. Extracorporeal life support is a reasonable approach for children with serious but reversible cardiopulmonary failure.

Adolescent↗
PubMed1989

Copper absorption and retention in young men at three levels of dietary copper by use of the stable isotope 65Cu.

Eleven young men were confined to a metabolic research unit for 90 d to determine the effect of the level of dietary copper on absorption and retention. Cu absorption was determined by feeding the stable isotope 65Cu. Absorption and retention averaged 36.3 +/- 1.3% and 0.17 mg/d, respectively, with an adequate-Cu diet (1.68 mg/d). Absorption averaged 55.6 +/- 0.9% and retention averaged -0.316 mg/d for 6 d and 0.093 mg/d for the next 36 d of a low-Cu diet (0.785 mg/d). Absorption averaged 12.4 +/- 0.9% with a high-Cu diet (7.53 mg/d) and retention was strongly positive at first, decreasing linearly with time. The study demonstrated that Cu absorption is strongly dependent on dietary Cu level and that Cu balance can be achieved by most young men from a diet of 0.8 mg Cu/d. These results suggest that current dietary Cu recommendations may be higher than necessary. The apparent regulation of Cu absorption and endogenous losses would tend to protect humans from Cu deficiency and toxicity.

Adult↗
PubMed1987

Apparatus for direct counting of beta-rays from two-dimensional protein gels: measurement of changes in protein synthesis due to changes in density of Chinese hamster ovary cells.

A method is described for scanning two-dimensional protein gels that utilizes direct counting of beta-rays instead of autoradiography. The methodology is compared with autoradiographic results and data are presented demonstrating changed patterns of protein synthesis accompanying changes in cell density. The method is rapid and permits identification of differences in protein abundance of approximately 10% for a substantial fraction of the more prominent proteins. A modulation effect of greater than 5 standard deviations is shown to occur for an appreciable number of the proteins that accompany the inhibition of cell growth due to contact inhibition. The method promises application to a variety of biochemical and genetic problems designed to delineate changes in protein synthesis accompanying changes in genome, molecular environment, history, and state of differentiation of the cell populations studied.

Animals↗
PubMed1985

Effect of zinc intake on copper excretion and retention in men.

To determine the influence of zinc intake on copper excretion and retention, nine men consumed diets containing 2.6 mg of copper/day and 1.8, 4.0, 6.0, 8.0, 18.5 or 20.7 mg of zinc/day for one- or two-week periods in a 63-day study. Copper and zinc in the diet and copper in plasma were determined weekly; fecal copper was determined daily and averaged within each week. The weekly mean (+/-SEM) plasma copper concentrations (81 +/- 3.3 to 100 +/- 5.8 micrograms/dl) remained within the normal range throughout the study. Fecal copper and apparent copper retention were influenced by the level of dietary zinc and the duration it was fed. When 18.5 mg of zinc/day was fed for two consecutive weeks following a lower zinc intake, fecal copper was elevated and apparent copper retention was reduced after a one-week lag. Thus, an intake of zinc only 3.5 mg/day above the RDA for men reduced apparent retention of copper at an intake of 2.6 mg/day.

Adult↗
PubMed1985

The lysine requirement of young growing male guinea pigs.

The lysine requirement of young, growing male guinea pigs was investigated by using crystalline amino acid diets containing 3.58% nitrogen. One hundred eighty-seven 3-wk-old guinea pigs were fed one of 10 crystalline amino acid diets ranging from 0.4 to 2.0% lysine or the control diet consisting of 30% casein in four 21-d performance trials. Diets were evaluated on the basis of changes in body weight, nitrogen retention, carcass weight, gastrointestinal tract weight, liver weight, hematocrit and hemoglobin plus carcass weight, gastrointestinal tract weight and liver weight as percentages of live body weight. A 0.7% dietary lysine level (0.875% lysine X HCl) was the lowest that gave results similar to those attained when casein or higher levels of lysine were fed.

Amino Acids↗
PubMed1984

Long-term effects of low histidine intake on men.

The purpose of this 85-day study was to investigate the long-term effects of histidine depletion on nitrogen utilization in young adult men. A low nitrogen (6.3 g/day), low histidine (10 mg/day) amino acid diet was fed to seven men for 8 weeks. Mean nitrogen balance became negative at the end of the 8-week period. Free histidine in postabsorptive plasma and 24-hour urine decreased significantly during the first 2 weeks of the depletion and remained low and constant for the remaining 6 weeks. Hemoglobin concentration decreased somewhat, and serum iron concentration increased significantly during histidine depletion. Lean body mass, urinary N'-methylhistidine and total creatinine did not change significantly. On addition of histidine to the low histidine diet for 2 weeks, nitrogen retention became positive, plasma and urinary histidine returned to initial values, serum iron fell, and hemoglobin concentration slowly increased. These parameters remained unchanged in two control men fed the same diet supplemented with histidine (1.05 g/day) for 8 weeks. The results suggest that histidine is indispensable for young men consuming a low nitrogen diet.

Adult↗
PubMed1982

Effect of acute zinc deprivation on plasma zinc and platelet aggregation in adult males.

In view of earlier results obtained with rodents, the present study was designed to investigate the effect of acute zinc deprivation in man on plasma zinc concentration and the response of platelets to aggregating agents. Three adult men consumed a formula diet based largely on soybean protein for 12 to 14 days. During the control period the diet was supplemented with 12 mg zinc per day. Without supplementation the diet supplied approximately 0.5 mg zinc per 3.0 Mcal; it contained 0.7 ppm zinc, and 0.2% phytate. After removal of the zinc supplement plasma zinc dropped rapidly and reached a minimum by the 5th day. There was a wide diurnal variation in plasma zinc concentration in one subject with the overnight fasting value being the highest and decreasing soon after the morning meal. Platelet aggregation in response to ADP and arachidonate was impaired when plasma zinc was 60 micrograms/dl or less and was restored to normal within 19 h of oral zinc supplementation. These results demonstrate that plasma zinc can be rapidly decreased by dietary zinc deprivation and that extracellular zinc plays an important role in platelet aggregation.

Adenosine Diphosphate↗
PubMed1979

Attitudes and food habits--a review.

The inadequacy of a definition of attitudinal terms has complicated the interpretation of many food habit studies. This review has focused on the multidimensional character of the word "attitude" as an aid to gaining insight into food habit development and change. The five definitional categories presented (attitudes as preferences, as overt food behavior, as willingness or ability to change, as agreement among family members, and as complexity of meanings) do not preclude other definitions. Knowledge of attitude studies can foster understanding of the link between nutritional knowledge and actual behavior, as well as help practitioners to be more effective in formulating objectives and developing techniques for nutrition education. The various dimensions and meanings of attitudes indicate the need for continued research to clarify the effect of well defined attitude variables on food habits.

Adolescent↗