PubMed Health⌕ Search

Biomedical subjects

H L Deutsch

Publications and source records attributed to H L Deutsch.

7 recordsLinked to original sources
PubMed1989

A new cocaine abuse complex. Involvement of nose, septum, palate, and pharynx.

A new complex of findings caused by cocaine abuse is presented. The complex consists of nasal collapse, septal perforation, palatal retraction, and pharyngeal wall ulceration. The findings and their causes are described. Pathologic evaluation to ensure that a concomitant disease, such as Wegener's granuloma, malignant reticulosis, autoimmune lesion, or various other destructive diseases, was not present was performed on only one patient. Although three patients presented with the findings caused by cocaine abuse, only one patient consented to the biopsy examinations. This case is presented in detail.

Adult↗
PubMed1986

Prolonged skin allograft survival through enhancement effects on donor tissue.

A skin allograft retransplantation model was utilized to study the mechanism of immunological enhancement in a murine system. Enhancement was accomplished by treating allografted recipients with host antidonor serum (B6AF1 anti-B10.D2 alloantiserum). Grafts from enhanced or untreated hosts were retransplanted after seven days onto a second recipient. Enhanced retransplanted grafts had significantly prolonged survival as compared with unenhanced grafts. The survival of enhanced retransplanted grafts was as prolonged as that of primary skin grafts on antiserum-treated hosts. Splenocytes harvested from recipients of enhanced retransplanted allografts showed delayed and diminished development of T cell responses to graft alloantigens. Sensitization of the second recipient abrogated prolonged survival of enhanced retransplanted grafts. Also, enhancement prevented sensitization of allografted recipients. One interpretation of these studies suggests that a sensitization block is a sufficient mechanism of skin allograft enhancement. The site of action of antisera is within the graft itself. Decreased T cell responses in the host are indirect effects of diminished antigenicity of enhanced grafts. Further studies of immunological enhancement should be directed to the graft, not toward the graft recipient.

Animals↗
PubMed1984

Retransplantation of murine skin allografts: assessment of treatment effects on the allograft in the absence of effects on the host.

In transplantation techniques previously described it was impossible to separate the effects of immunosuppressive treatments on the host from the effects directed at the allograft itself. The skin allograft retransplantation technique described here allows one to assess changes in the immunogenicity of the allograft generated in the primary recipient but assessed on a second untreated host. The skin allograft is parked on a primary recipient and then retransplanted with a thin margin of recipient tissue to a second host. Data obtained from this model shows that passenger leukocytes do not influence skin allograft survival times. Enhancing alloantisera used in the primary host was shown to cause prolonged graft survival in the untreated second recipient. Using this model the effects of immunosuppressive or immunostimulatory treatments directed at the graft itself can be assessed.

Animals↗
PubMed1980

Resection of platysma bands in face-lift surgery.

The anatomy and function of the platysma muscle, its hypertrophy together with the submental fat pad in producing cosmetic defects, and the technique of resecting hypertrophied platysma muscle and submental fat to remove cosmetic defects are discussed and described.

Face↗
PubMed1979

Treatment of small external cancers of the nose.

There are various ways to remove and repair defects on the nose. When dealing with small basal cell or squamous cell carcinomas, the authors have been utilizing either skin grafts alone or composite skin-cartilage grafts from the ear. We believe that these procedures are simpler for the doctor and easier on the patient, with aesthetically pleasing results.

Basal Cell Carcinoma↗
PubMed1977

Acinic cell tumor of the palate.

A rare acinic cell carcinoma of the soft palate is reported and its potential for recurrence and metastasis discussed. A wide ablation created a speech-crippling defect that was reconstructed with an island flap from the opposite side and a pharyngeal flap for nasal lining and an island flap from the same side for oral cover. Speech is again normal.

Adult↗