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Biomedical subjects

H L Needleman

Publications and source records attributed to H L Needleman.

At least 73 records · Page 4Linked to original sources
PubMed1983

Lead and the relationship between maternal and child intelligence.

Using regression analysis, we show that the IQs of children with elevated levels of dentine lead (greater than 20 parts per million) are below those expected, based on their mothers' IQs. Moreover, the amount by which a child's IQ falls short of the expected value increases with increasing levels of dentine lead in what may be a nonlinear fashion. Although lead level contributed nothing to the prediction of IQ for children with low levels of dentine lead (less than 10 parts per million), it rivaled maternal IQ in importance as a predictor in the group with elevated lead values. Thus for schoolchildren with lead burdens in the highest decile of the distribution for the urban area we sampled, the usual relationship between maternal and child IQ appears to be disrupted in a manner systematically related to lead levels in dentine.

Dentin↗
PubMed1983

Lead at low dose and the behavior of children.

Over 3,000 children attending first and second grade in public school were classified as to past lead exposure according to the concentrations of lead in their teeth. Those in the highest and lowest deciles for lead were evaluated by a broad panel of neuropsychologic outcome measures. Controlled either by matching or analysis of covariance were 39 other variables which could effect outcome. High lead children were significantly impaired on IQ auditory processing and reaction time under varying intervals of delay. Teacher's rating scales showed a dose-related increase in non-adaptive classroom behavior with no evidence of a threshold. EEG scores and observations of children in class demonstrated differences in high and low lead subjects.

Child↗
PubMed1982

Temporal trends in the lead concentrations of umbilical cord blood.

Umbilical cord blood specimens from 11,837 births between April 1979 and April 1981 have been analyzed for lead by anodic stripping voltammetry. The mean was 6.56 +/- 3.19 (standard deviation) micrograms per deciliter of blood, and the range was 0.0 to 37.0 micrograms per deciliter. The mean decreased annually by 0.77 +/- 0.03 microgram per deciliter, about 11 percent. Lead concentrations were higher in infants born in summer than in infants born in winter (7.17 versus 5.99, probability less than .001). A Fourier model of the data is presented, and possible reasons for the decline are discussed.

Boston↗