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Biomedical subjects

H L Zauder

Publications and source records attributed to H L Zauder.

At least 19 recordsLinked to original sources
PubMed1994

Controversies in transfusion medicine. Perioperative hemodilution: pro.

Hemodilution can obviate the need for allogeneic transfusion in some patients. However, it is only one component of a comprehensive blood conservation program and should be combined with other techniques whenever possible. While most often employed in teenagers and healthy young adults, ANH has been used in small children, the elderly, and patients of all ages who are undergoing cardiac surgery. Extreme caution should be exercised if ANH is used in patients with coronary artery disease or aortic stenosis who are undergoing noncardiac surgery, because their normal compensatory mechanisms are impaired. What usually is a safe and relatively simple procedure can become a disaster if employed in inappropriately selected patients. Careful hemodynamic monitoring and maintenance of normovolemia are critical.

Adolescent↗
PubMed1991

Autologous blood salvage procedures.

Autologous transfusion is not a luxury. Some states have passed legislation mandating that surgical patients be informed of the alternatives to homologous blood administration as well as the risks and benefits of transfusion. Technological advances have made autologous blood salvage in surgery, the postoperative period, and certain trauma situations a safe and relatively inexpensive procedure. While there is minimal data documenting the quality of blood which is administered without processing, extensive clinical experience attests to the safety of the procedure. Ample clinical and laboratory data support the safety of reinfusing processed blood.

Animals↗
PubMed1991

Chin holders.

Explore the source record for details and available documents.

Anesthesia, Inhalation↗
PubMed1982

Massive transfusion.

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2,3-Diphosphoglycerate↗
PubMed1979

Cardiovascular responses to diazepam and midazolam maleate in the dog.

Previous clinical studies establishing the efficacy of midazolam maleate (RO 21-3981), a new water-soluble benzodiazepine for induction of anesthesia, have not critically evaluated the effects of this agent on the cardiovascular system. The present study compares the cardiovascular effects of midazolam maleate and diazepam in conscious dogs. Systemic arterial, pulmonary arterial and central venous pressures, cardiac output, LVmax dP/dt, heart rate and regional coronary blood flow were measured 3 min following intravenous administration of diazepam (0.5, 1.0, and 2.5 mg/kg) or midazolam maleate (0.25, 1.0, and 10.0 mg/kg). Midazolam maleate increased heart rate 10--20 per cent with all three doses and decreased mean arterial blood pressure approximately 10--20 per cent at 1.0 and 10 mg/kg. Cardiac output was increased 10--12 per cent with all three doses of midazolam maleate, and LVmax dP/dt was decreased 13--16 per cent at the two higher doses. Diazepam at all three doses did not alter heart rate or mean arterial blood pressure. Diazepam, 1.0 and 2.5 mg/kg, produced significant (17 per cent) decreases in LVmax dP/dt, and 2.5 mg/kg produced a significant (10 per cent) increase in cardiac output. Neither drug in any dosage altered regional coronary blood flow, systemic or coronary vascular resistance, stroke volume, or stroke work. Maximum alterations in cardiovascular variables occurred with doses of midazolam maleate that are 10--15 times the recommended clinical induction dosage. It is concluded that in concentrations necessary for induction of anesthesia midazolam maleate has minimal effects on cardiovascular function.

Animals↗