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Biomedical subjects

H Löe

Publications and source records attributed to H Löe.

At least 55 records · Page 3Linked to original sources
PubMed1991

Errors in measuring parameters associated with periodontal health and disease.

The intra-examiner reliability for the Plaque Index (PII), Calculus Index (CI), Gingival Index (GI), and periodontal loss of attachment (LA) was evaluated in 2 different physical and clinical environments. Examiner reliability for each index was consistently better when clinical evaluations were performed in an office setting on subjects who had low levels of periodontal disease than under more difficult field conditions evaluating subjects with higher disease levels. In an office environment intra-examiner reliabilities were very good for subject-based averages (intraclass r's were 0.85, 0.83, 0.81, and 0.78 for GI, PII, LA, and CI, respectively); they were moderate to good for site-based scores (kappas were 0.63, 0.54, and 0.47 for CI, GI, and PII). Under field conditions reliabilities ranged from excellent to fair for subject-based averages (intraclass r's of 0.98, 0.86, 0.76, and 0.33 for LA, CI, GI, and PII, respectively); for site-based scores they ranged from moderate to fair (kappas of 0.50, 0.49, and 0.21 for GI, CI, and PII, respectively). Small but significant systematic errors were detected under field conditions for the PII and CI, and for the PII in the office environment as well. The results observed suggest that the examination process can affect the clinical status of the surface or site when replicate assessments of plaque and calculus are conducted within a 24-hour period. Our results also confirm that measurement error standard deviation for loss of attachment evaluated with a periodontal probe can be maintained at 0.13 mm for whole-mouth means and 0.54 mm for individual sites, even when examining subjects with substantial periodontal disease under field conditions.

Analysis of Variance↗
PubMed1990

Teeth for life: oral disease prevention in research and practice.

All branches of dentistry have benefited in recent years from the rapid advances made in scientific research. Caries has been reduced in industrialized countries thanks to the combined efforts of epidemiologists, chemists, experimental and clinical scientists, identifying fluoride and refining fissure sealants. Genetic engineering may be pointing the way towards a possible caries vaccine as well as enhancing regimens against periodontal diseases. In addition research has provided advances in preventing and treating soft-tissue pathologies. Over the next 20 years a research and action programme aims to eliminate toothlessness in the USA.

Adolescent↗
PubMed1989

Forty years of progress.

The celebration of the 40th anniversary of the National Institute of Dental Research (NIDR) provides an opportunity for reviewing the growth of dental research over the decades. The Institute owes its origin to public and professional concern over the dental health of Americans and the prospect that a Federal investment in dental research could pay off. The early years of the Institute were devoted to studies of fluoride and dental caries, with notable achievements in clinical trials of water fluoridation and caries microbiology. During the 1960s came the discovery that the periodontal diseases, like dental caries, were bacterial infections that could be prevented. Basic and clinical research expanded, and the research manpower pool grew with the addition of microbiologists, immunologists, salivary gland investigators, and other basic biomedical and behavioral scientists. The Institute created special broad-based Dental Research Institutes and Centers to foster interdisciplinary research, and continued to expand its research base. A national survey undertaken by NIDR in the late 1970s showed major declines in caries prevalence in schoolchildren. Recent NIDR surveys of adults and older Americans as well as a second children's survey have demonstrated overall improvements in oral health and a continued decline in childhood caries.(ABSTRACT TRUNCATED AT 250 WORDS)

History of Dentistry↗
PubMed1989

Periodontal diseases in the U.S. in 1981: prevalence, severity, extent, and role in tooth mortality.

Prevalence, severity, and extent of periodontal diseases as well as the role of periodontal diseases in tooth mortality are described for persons 19 years and older in the U.S. in 1981. The data were collected with a household probability sample of non-institutionalized persons living in the contiguous 48 states. Plaque and calculus scores were collected for six index teeth. All permanent teeth present and capable of being assessed were scored for gingivitis; pocket depths were measured on the mesial of each tooth with a periodontal probe. Examinations were conducted by trained dentists calibrated on specific criteria. Only 15% of persons in the U.S. in 1981 were free from any sign of periodontal diseases. Periodontitis (pockets greater than or equal to 4 mm) affected approximately 36% of the population. Advanced periodontitis (pockets greater than or equal to 6 mm) was present in 8% of the population and was usually found on only one or two teeth when present. End-stage periodontal destruction requiring extraction of teeth was found in only 4% of all persons while less than 20% of all missing teeth were listed as missing due to periodontal disease.

Adult↗
PubMed1989

An estimate of periodontal treatment needs in the U.S. based on epidemiologic data.

It has generally been assumed, based on previous epidemiologic and utilization studies as well as the increasing elderly population, that there would be an increasing need for periodontal treatment. Analysis of a more recent household epidemiologic survey conducted in 1981 indicates that the need for treatment of periodontitis is less than previous estimates. These epidemiologic data have been translated into treatment needs through a series of conversion rules derived from previous studies and current patterns of treatment, and applied to the 1985 U.S. population. The total periodontal services needed for scaling, surgery, and prophylaxes would require 120 to 133 million hours and $5 to $6 billion annually if the total population were treated for periodontitis over a 4-year period. Only 11% of the total hours needed would be for scaling and surgery whereas 89% would be needed for prophylaxes. Expenditures for periodontal treatment total approximately 10% of the amount being spent on dental care in 1985. On the basis of these data, it seems unlikely that there will be a substantial increase in the need for periodontal treatment in a growing and aging U.S. population. These figures represent the upper limits of treatment need and are reduced by factoring in current utilization of periodontal treatment.

Adult↗
PubMed1988

Systematic errors in estimating prevalence and severity of periodontal disease.

Partial-mouth scores are often used in epidemiologic studies to estimate the prevalence and severity of periodontal disease. Such estimates systematically underestimate the prevalence of disease, but the bias can be in either direction for disease severity. Three large data sets containing full-mouth examinations (mesiobuccal, midbuccal, distobuccal, and midlingual (MBDL) sites per tooth) for either attachment loss or probing pocket depths were used to investigate the magnitudes of systemic error that occur by employing four specific partial-mouth scores (M, MB, MBD, and MBDL sites per tooth), which are based on the random half-mouth technique. For prevalence of disease the sensitivity of a partial score was a function of the disease level in the population. All four partial scores were sensitive enough to adequately portray true prevalence using the 2-mm demarcation value, the MBD and MBDL scores might still be considered adequate for the 4-mm value, but none of these partial scores were adequate for the 7-mm value. For disease severity the MBDL score produced unbiased estimates, the others were biased. The relative biases for the MB and MBD scores were all under 10% (in absolute value), but the M score produced severe relative biases, 24% for probing pocket depths and -12% for attachment loss.

Cross-Sectional Studies↗
PubMed1988

Periodontics of tomorrow.

In the early post-World War II years, there was no unified paradigm to explain the etiology of periodontal diseases. Subsequent studies established that the diseases were caused by bacteria colonizing the gingiva and subgingiva, leading to rational approaches to treatment and prevention. Research to identify the principal and bacterial species involved and clarify host immune responses continues, aided by new cell and molecular techniques. Epidemiologic surveys show improved oral health in adults but indicate problems among older Americans. Future research should expand studies of periodontal tissue regeneration, resolve questions of disease activity and progression and include oral health promotion programs targeted to adults.

Adult↗
PubMed1986

Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age.

This paper describes the initiation, rate of progress of periodontal disease and consequent tooth loss in a population never exposed to any programs or incidents relative to prevention and treatment of dental diseases. The group consisted of 480 male laborers at two tea plantations in Sri Lanka. The study design and baseline data have been published. At the initial examination in 1970, the age of the participants ranged between 14 and 31 years. Subsequent examinations occurred in 1971, 1973, 1977, 1982 and 1985. Thus, the study covers the age range 14-46 years. Throughout the study, the clinical indices were scored by the same two examiners, both well-trained and experienced periodontitis. Intra-examiner reproducibility for each index was tested at baseline and repeated periodically during the study. The data for each examination were computerized and updated on an ongoing basis. At the last examination in 1985, there were 161 individuals who had participated in the first survey. This population did not perform any conventional oral hygiene measures and consequently displayed quite uniformly large aggregates of plaque, calculus and stain on their teeth. Virtually all gingival units exhibited inflammation. Based on interproximal loss of attachment and tooth mortality rates, three subpopulations were identified: (1) individuals (approximately 8%) with rapid progression of periodontal disease (RP), those (approximately 81%) with moderate progression (MP), and a group (approximately 11%) who exhibited no progression (NP) of periodontal disease beyond gingivitis. At 35 years of age, the mean loss of attachment in the RP group was approximately 9 mm, the MP group had approximately 4 mm and the NP group had less than 1 mm loss of attachment. At the age of 45 years, the mean loss of attachment in the RP group was approximately 13 mm and the MP group approximately 7 mm. The annual rate of destruction in the RP group varied between 0.1 and 1.0 mm, in the MP group between 0.05 and 0.5 mm, and in the NP group between 0.05 and 0.09 mm. Since this population was virtually caries free, essentially all missing teeth were lost due to periodontal disease. In the RP group, tooth loss already occurred at 20 years of age and increased throughout the next 25 years. At 35 years of age, 12 teeth had been lost, at 40 years of age 20 teeth were missing and at 45 all teeth were lost. In the MP groups, tooth mortality started after 30 years of age and increased throughout the decade.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1986

Periodontal health and disease in young people: screening for priority care.

Gingivitis is the most common chronic disease affecting young people. Almost all teenagers exhibit gingival lesions in the interproximal areas of posterior teeth. Gingivitis is caused by supragingival bacterial plaque which contains more than 165 species and subspecies. No single organism or group of bacteria can be directly implicated in the development of gingivitis. Periodontitis occurs before 20 years of age, is also first found in the interdental areas of posterior teeth and is preceded by gingivitis. It progresses slowly through the decades of adult life with varying rates in different individuals and teeth within the same mouth. Subgingival plaque contains more gram-negative, anaerobic organisms and more motile bacteria than supragingival plaque. Progression of periodontitis coincides with the occurrence of certain Bacteroides species, fusobacteria and other anaerobic motile rods as well as spirochetes. However, at this time the concept of specific pathogenicity cannot be applied. Rapidly progressing localized or generalized periodontitis is characterized by the rate of periodontal destruction and usually occurs in less than one per cent of juveniles. These patients exhibit increased prevalence of Actinobacillus actinomycetemcomitans and abnormalities in neutrophil function. At present, simple clinical screening tests that can predict who will and who will not suffer from chronic periodontitis, that can provide early identification of high risk patients or forewarn the development of juvenile periodontitis are non-existent. Research in this area is seeing significant progress and several technologies have shown promise. While awaiting new screening methodologies, the clinician must continue to rely on periodontal probing, radiographic techniques, visual inspection and clinical acumen as the main means of periodontal diagnosis.

Adolescent↗