Biomedical subjects

H Løkkegaard

Publications and source records attributed to H Løkkegaard.

42 records · Page 3Linked to original sources

PubMed1981

Cold hypersensitivity and finger systolic blood pressure in hemodialysis patients.

In patients on maintenance hemodialysis the blood pressure in the fingers of the arm with arteriovenous fistula was significantly lower than in the fingers of the other arm. This is explained by the increased arterial blood flow to the arm with the fistula, giving physiological pressure reduction. Six of ten uremic patients on maintenance hemodialysis complained of Raynaud's phenomenon. This was confirmed by a cold provocation test, which showed significant improvement after hemodialysis. The mechanism of Raynaud's phenomenon in these patients is assumed to be functional, but no clear explanation has been found.

Adult↗

PubMed1981

HLA-DR typing in cadaver kidney donors and recipients in Copenhagen.

Among 224 cadaver kidney transplantations performed since Spring 1977, successful DR typing of both donor and recipient could be done in 149 cases. Assessment of DR match grade and clinical data was done independently. The minimum observation time was 3 months and the time of follow up was 1 December, 1980. There was an effect of DR matching which became significant when only 1. transplants were considered and high risk recipients (i.e. diabetics) excluded. Transfusions were of minor importance on graft survival and the difference was only obvious in the first year after transplantation. Matching for HLA-A, B antigen had no obvious effect on graft survival in this material.

Blood Transfusion↗

PubMed1977

Is renal osteodystrophy reversible?

In order to investigate the possible reversibility of renal osteodystrophy, eleven necrograft recipients were investigated six years after transplantation, when treatment with prednisone had been withdrawn for 1.5 years. Serum ionised calcium, phosphorus, alkaline phosphatases, PTH, skeletal radiography, Technetium polyphosphate (Tc-PP) bone scintigraphy and radial bone mineral content (BMC) were studied. Normal blood biochemistry, radiography and Tc-PP scintigraphy were found in nine (82%) of the patients, in contrast to the considerably higher frequency of abnormalities ordinarily found in haemodialysis patients. However, the radial BMC was significantly reduced (mean 13.5%) and identical with the BMC value in haemodialysis patients. We conclude that some regression of renal osteodystrophy may take place after a successful kidney transplantation, but that decreased mineralisation of the appendicular skeleton persists. Whether this latter finding is due to long-term steroid treatment or is an indicator of an irreversible component in renal osteodystrophy cannot be stated.

Adult↗

PubMed1977

Permanent withdrawal of prednisone in nekro-kidney transplantation.

Starting 2.5 (2.0-3.9) years after grafting prednisone (but not azathioprine) has been gradually reduced below the conventional maintenance dose of 10 mg per day in 43 and has up until now eventually been completely withdrawn in 23 out of 47 consecutive patients with a first nekro-kidney transplant, which was well functioning at 2 years after transplantation. There appeared to be an increased risk of rejection during reduction of prednisone from 10 to 2.5 mg per day, but 20 out of the 23 patients in whom prednisolone has by noe been completely withdrawn have maintained stable and normal graft function over an average period of 1.6 (0.1-3.0) years on zero prednisone.

Age Factors↗

PubMed1977

Experimental and clinical experiences with long-term kidney preservation by use of simpel hypothermia.

In an experimental work published in 1973, it was found, that it was possible to preserve pig kidneys with up to one hour of warm ischemia for 24 hours using pretreatment with chlorpromazine and subsequent preservation with simpel hypothermia (Collings C2-solution). Clinical experiences with this method are now presented and confirm, that this method allows preservation of ischaemic damaged kidneys for about 24 hours.

Animals↗

PubMedDate not supplied

Angiography in non-functioning renal allografts receiving cyclosporin A.

During a two-year period angiography was performed in 10 out of 40 initially perfused kidney allografts within the first 3 postoperative weeks. Immunosuppression was in all cases performed with cyclosporin A. The indication for angiography was mainly deterioration in the graft function as judged from the renograms or inadequate demonstration of the graft during intravenous radionuclide angiography. At angiography, neither arterial nor venous occlusion was found, and it was normal in 5 patients. It is concluded that during cyclosporin A treatment angiography cannot be recommended on the above mentioned indications in the early postoperative period. A graft biopsy seems sufficient.

Cyclosporins↗