Biomedical subjects

H Lü

Publications and source records attributed to H Lü.

20 records · Page 2Linked to original sources

PubMed1996

Ankylosing spondylitis and heterogeneity of HLA-B27 in Chinese.

OBJECTIVE: To examine the relationship between ankylosing spondylitis and heterogeneity of HLA-B27 in Chinese. PATIENTS AND METHODS: We subtyped HLA-B27 in 76 patients with ankylosing spondylitis and 1 200 healthy Chinese of Han nationality. Polymerase chain reaction was designed to amplify specific regions of class I (exon 2 and 3). Amplified sequences were tested with eight sequence-specific oligonucleotides to distinguish all HLA-B27 subtypes. RESULTS: The HLA-B27 was closely related to ankylosing spondylitis and at least four subtypes presented in Chinese patients. B2704 was the most common subtype, occurring in 54.8% and 50.85% respectively in HLA-B27 positive ankylosing spondylitis patients and healthy controls. The main HLA-B27 subtypes in the HLA-B27 positive patients distributed in similar proportion to those of HLA-B27 positive healthy controls (P < 0.1). CONCLUSIONS: The prevalences of various subtypes of HLA-B27 vary in different races. HLA-B2704 is the main subtype in Chinese Han nationality. The HLA-B27 specific residues that are shared by the subtypes might be involved in the pathogenesis of ankylosing spondylitis.

Adolescent↗

PubMedDate not supplied

Maternal determinants of birth weight: a population-based sample from Qingdao, China.

This analysis examines the relationship between maternal determinants and birth weight in a population-based birth cohort of 5,284 mothers with singleton births of 28 completed gestational weeks in Qingdao, China, in 1992. Multiple linear regression models suggest that the length of the menstrual cycle, age at menarche, maternal weight, maternal height, parity, and number of antenatal visits had independent effects on birth weight after controlling for gestational age and sex of infant. The estimated difference in mean birth weight for each year after menarche was 11.7 g (95 per cent CI 4.6-18.8), and for each day of the menstrual cycle was 4.0 g (95 per cent CI, 2.1-6.0), after controlling for gestational age, sex of infant, maternal height, maternal weight, parity and the number of antenatal visits. No substantial differences in determinants of birth weight were found between the sexes. Maternal age, education, and occupation failed to reveal any significant association with birth weight. In sum, those women who reached menarche younger and had a relatively short menstrual cycle had a heavier baby on average, and the determinants of birth weight did not differ between male and female in the cohort.

Adolescent↗