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H Leblanc

Publications and source records attributed to H Leblanc.

62 records · Page 4Linked to original sources
PubMedDate not supplied

[Value of combined subcutaneous infusion of insulin and metformin in 10 insulin-dependent obese diabetics].

Combined continuous subcutaneous insulin infusion (CSII) and metformin (M) was tested in 10 overweighted insulin requiring diabetic patients (body mass index 27.9 +/- 4.9 kg/m2). They were still poorly controlled (HbA1 9.6 +/- 0.8%) despite large doses of lente insulin (Novo) (51.7 +/- 19.6 IU/24 h) injected once daily. With CSII after two weeks on placebo (P) they were enrolled in a randomized double blind cross-over trial with two successive one month periods of M (2550 mg/day) or P. At the end of the two-weeks period CSII--initial P, the daily regular insulin requirement decreased significantly (40.1 +/- 18.1). During M and P body weight and HbA1 were unchanged (respectively 28.6 +/- 6.0 vs 29.0 +/- 59 kg/m2 and 7.7 +/- 1.1 vs 7.7 +/- 0.8%). With M daily insulin requirements decreased significantly (32.0 +/- 16.8 vs 38.4 +/- 18.2 IU, p less than 0.05). During test-meals, M compared to placebo also reduced peripheral free insulin concentrations (-24.9 +/- 26.0%) while plasma glucose and C peptide remained comparable. In the conditions of this study, combined CSII and M reduced the insulin resistance observed in overweighted insulin requiring diabetic patients.

Adult↗
PubMedDate not supplied

[New antihypertensive therapy in diabetics].

According to the W.H.O. criteria (160/95 mmHg), arterial hypertension is present in about one third of diabetic patients. But the W.H.O. criteria are not appropriate in insulin-dependent diabetics. There is increasing evidence that a slight increase of blood pressure values may have a deleterious effect on various localizations of diabetic angiopathy. Arterial blood pressure is a major predictive factor for stroke or death due to coronary heart disease. The incidence and prevalence of diabetic retinopathy are significantly correlated with systolic and/or diastolic blood pressure values. In patients with incipient diabetic nephropathy, a slight elevation of blood pressure values is usually observed, an antihypertensive treatment may reduce albumin excretion rate and may prevent clinical diabetic nephropathy. Antihypertensive treatment is the more effective and the best tolerated of all interventions dedicated to reduce albumin excretion. Calcium antagonists and angiotensin converting enzyme inhibitors are at the present time the drugs to be used in the treatment of hypertensive diabetic patients as they are more effective and better tolerated than the usual antihypertensive agents. A part from their antihypertensive effect, they also improve cardiac, cerebral and intra-renal haemodynamics.

Angiotensin-Converting Enzyme Inhibitors↗